ID A0A2J7PJA1_9NEOP Unreviewed; 1776 AA.
AC A0A2J7PJA1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Murinoglobulin-1 {ECO:0000313|EMBL:PNF16412.1};
GN Name=Mug1_2 {ECO:0000313|EMBL:PNF16412.1};
GN ORFNames=B7P43_G10496 {ECO:0000313|EMBL:PNF16412.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF16412.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF16412.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF16412.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF16412.1}.
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DR EMBL; NEVH01024950; PNF16412.1; -; Genomic_DNA.
DR STRING; 105785.A0A2J7PJA1; -.
DR InParanoid; A0A2J7PJA1; -.
DR OrthoDB; 2970602at2759; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF171; PREGNANCY ZONE PROTEIN-LIKE PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1776
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014400351"
FT DOMAIN 469..648
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 835..925
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1446..1535
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1776 AA; 198810 MW; 2A0897D468DDBCFA CRC64;
MKVACLCVFV LVLAVQATSA SSNRGFVFLA PKRLLADSTE SVCLSLHNVT GTAHVSVDVL
HPDSDDKITS TQHKFKNGVG GCLALFVPPV QLSRARLHLK VRFDEHYDYN INSVKEVHIQ
HDPYIVLIQT DKPVYKPGQE VKFRILTLTH DLMPVAGTIS RVWIESPSQV RLAQWLDVST
EQGLVQLSFQ LSHEPPQGLW EIKVERNKSH THVQKFEVRE YVLPRFEVTI KAPEYILADA
GYLNWNICAK YTYGQPVKGQ LHIKAIPQTP TWRQRKTKPP EINVMTQLNR TDGCYTFSIT
GTELGLHDWD IAPNSIVVSA FVTERGTDNI QNVTSVTSVI HQALKLEFLP HSSQYFKPGL
PYKGKVKVLK QDNTPAIGEV LQLCLKVRGK GEWSRTLVMC KNFTSDVEGF VQFLVPPQHH
NVVLLSFVAT AVGYQTKYYS PDKRWRVFMD QPSAFFDVHT WFSPTDSYIE ITDKNEKTLK
CESDHKFDIY YTAQPNVTQL TFHYLVKSRG DLIQFGEIQH HTQNQKLRLY EGFVNILGGN
DDADRNSSEE AEDEGATVEK SVDKVALHIK ILPKMSPLSY LLVYYVREDG ETVASMYTIR
VNKCFANKVV AKFSEHRQFP GSETLLEISA SPHSLCAVSA VDKSISFLGK PGSKLDVDRM
FQDLSRFAID ANSAPLQTDP WEYCAKKAQG REDVTSMAGT EEVSQKPSRG VVVEPPFWDL
RRRRRKRFIA TQPPSKYVDS IQAFDDFGVV VMSDLTVETR PCNTMTGQQE GMFLERSSML
KRSDEAESSP IRGLMMPNTP PLAFPLVVKA ATMLQGYMED SRPSAVEVRS FFPETWLWEL
QYTGDSGVLT LNREVPHTIT EWIGTTVCVS PQLGLGISPP AHLTAFQPFF LDYSMPYSVK
RGEVVQLKVS LFNFLSYSLP VRIVFEDPHG VELINDNSTV LACVAERTTF VQQFHIRASD
LGKVNITVSA EVDPSYPEEC GPEILVHRRD VLVRPILVHP EGFPIEITKS AFICPSNFSE
DENVLWSLEL PPDVVEDSAR ADVSVVGDLL GPTLQNLGHL VRMPVGCGEQ NMILFVPNLH
VINYLNATQQ ENLVLKAEAI KNMEKGYQRE LNYRHTDGSY SAFGDTDAEG SMWLTAFVVK
SFSQARGYIY VDEDDLKVSM RWITKKQLEN GCFPLVGKVF HKDMKGGLTG ETSSAALTAY
VLISLLETGL PLPPSVISNC MFCLKGAADP DIYTLVLTTY AFTLLGEREM AEESLERLLS
MATRQQDLSW WEKSGTSSLG LSVEMTAYAV LSLVKLGGEE NLINAFQAVR WISKHRNAEG
GFVSTQDTVV ALEALTKYAV MLPRSENGVS VVVTATEMEH TFHIHEHERL LLKRQHLPVL
PTQVEMDAIG EGCALVQTSL RYNVRNASGS DAFDLEVRTG PVASVDECTM QRIEACVRYK
LPDQTSNMAV LEVYMVTGYV PEQASLYQLL HQQDISVKRW EEAKDHVNLY FEELSTRRQC
VGFLVVQETE VENPAPAIVR VYDYYQQELS VSTKYTTDGG CRNEKLPHPQ PDIFNEDGVI
TKQESLSDEL EAVDVLPQDF QEVTANINEV QVDVIQADSS TLNSMNGTEG LNAQFVDVDH
EMETPSGEEG PVPSYALPQA DVDPNVTGAA ISCPTCDDSP PSNFTELYCN SGTVYKLSTR
KDNNSRLLMN MSPGQPARRI RRVVKLVLGV DCRCKPLEKV GGHILLLDQN ANMSYIEDEV
DTESTPELKL NSSMILIGVE TLPGQPEIVK VARNGC
//
