ID A0A2J7PLI2_9NEOP Unreviewed; 1483 AA.
AC A0A2J7PLI2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=FYVE, RhoGEF and PH domain-containing protein 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=B7P43_G06588 {ECO:0000313|EMBL:PNF17188.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF17188.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF17188.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF17188.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF17188.1}.
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DR EMBL; NEVH01024425; PNF17187.1; -; Genomic_DNA.
DR EMBL; NEVH01024425; PNF17188.1; -; Genomic_DNA.
DR STRING; 105785.A0A2J7PLI2; -.
DR InParanoid; A0A2J7PLI2; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13389; PH1_FGD5_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 912..1101
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1122..1226
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1265..1324
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1380..1481
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1483 AA; 166818 MW; 82528CC0C6FC4295 CRC64;
MAAVPGKRKP PTPPKPPLLG HLAGPALVIH GDSYKGRCDS RLQGGGRAKD DHIYDEIVSA
CKETAVEKKT DVHKTKPAEA LDGMLGAATR ERTQCCDVMK CSIDKPSVKP PLLPKPQTSP
NIHTTSPNLG SRPLIPARSN LVPSIATNGK ELAVHSKKKK PPSLNSASTN NRGQIANRRF
PLHIKAPVAK LEEFEGFSDT VKSDSPVRPP RSPKHQSFKG EPFKGFDEKP QLPLKRKEWN
CHATHAVPGS GSNFEALQMH WQTTKEKSAS LGRTNAFRYV EAKAKSASLG RNMPADFASY
LVNQEESCSL GNKNTPVPPP RQKKKQCGHP HSIPLYAEVN YSLKKNRRQT AEERKECSDC
VIDADDAEVQ EQMAVIEGKL ILPGPKNESS VSKVEKIITE ACESFEKNRI CQNIEAMNEP
NETEVVKEVG VRGKEVNVVD ECETLNSLHL DNDCVISQDK VLNTSDLDFT ITDNNDCVSH
ICSVDNKTSV TSGNISPVVE LEVKLPAKES STSSSLLVET EVHSLAEKSL ITSPFSAPAE
EKHSDSYLEC SSAEAQEDLK PGNVKWQSSK LSVSGSDLDS AEHRAVEGNS SELYHIIYSR
SEKFSESEVA VFTNTESVDS VKDNSDISVN NAVDNFEVKC NEQVLVKERD VISLVDADVS
QNAGSDDTEY RLLEASLLVK RKLEMKELGK LPRRRLSWSN WKDDSPSPET TLHRLPCAHK
HKSKTHSLWC DEGELSSGVL GDLDSSDTTA RQSSFEEVDH TGSDAEDRSN LVQSKLSTWL
GSFGKGNRKQ KLIRDSNSHF YCDSRENFDQ TKREEEPEKE QIPVVEVTES ASAEIQEIEV
GGFNFTILDG SRPPSGLSTL SALDTDQKSD VPVSEESFEM YHHSESENET EINPEDRDEN
HSQVEETRQD KKAFYIAQEL MTSERAFIDV LKLLSVDFRQ AVHAVAARQR YPVIPDAELD
KILNSLPQLR SLNEDLLRDL EIRINNWNSI KKIADVIVRK GPFLKLYTSY IQNFESQCIY
LDECCQKYHR FAKVVKEFEA SPRCQKLSLK HYMLKPVQRI PQYRLLLEDY LHHLSPFSPD
LDDTRTALKI VCDVADHANR SIKLGDHLSK LLQLQSQLGN YEIIKPGRMF LKDGELSKLS
RKGMQPRYFI LLNDCLLYTS YYGSVQSSGL KVNYELPLSS MKVSIPQAED YRNEFSIISV
KRSFTLSARS LNERQEWVDA LQKAITDYNS RQLSFQNMKV TSSAKNECSS EPFKLGQEAP
VWIQDRRVTM CQSCTAEFTV TFRRHHCRAC GKVVCGDCSD FRAPLQYMRF QSARVCEECH
NTLLKEARDP TSEVNQAMKH ELGNTISIMD AFKRLGPVSG KRVKKYIPQR LKEVTANDTG
SQMSGWLQRR SRRSWKRLWF VLKEQVLYVY KASEDVVALE SIPVLGYAVE PMKERHFQLY
EGIDAKFVFK LAHPGQRPLI FHADSEHLAN RWIAAMSEAT VLK
//
