ID A0A2J7PX46_9NEOP Unreviewed; 975 AA.
AC A0A2J7PX46;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN Name=hira_1 {ECO:0000313|EMBL:PNF20894.1};
GN ORFNames=B7P43_G11193 {ECO:0000313|EMBL:PNF20894.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF20894.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF20894.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF20894.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF20894.1}.
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DR EMBL; NEVH01020862; PNF20894.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7PX46; -.
DR STRING; 105785.A0A2J7PX46; -.
DR InParanoid; A0A2J7PX46; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 66..100
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..159
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..201
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 717..917
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 409..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 106065 MW; D5867A31105B15D7 CRC64;
MKLLKPNWVS HDDLPIFSID IHPDGSRFAT GGQGEDSGRI VIWNMAPVVS EKIENDENVP
KMLCQMDNHL ACVNCVRWSF SGKFLASGGD DKLIMIWKIS KYASAGGNTV FGSGKVNVET
WRCATTLRGH NGDVLDMAWS PHDAWLATCS VDNTVIVWNA LKMPEMVAIL KGHSGLVKGV
AWDPVGKYVA SQSDDKTLRI WRTADWQQDA IISEPFEECG GTTHVLRLSW SPDGQYLVSA
HAMNGGGPTA QIVEREGWRQ DKDFVGHRKA VTCVRFNSNI LQKSYKSWCK PQQYCCCAIG
SRDRSLSVWL TALKRPLVVI HELFSNSVLD LSWSGSGLQL MACSWDGSVA FVEFSEEELG
KPLTLEEKST LHERMYGKFL SPSARQTCVV ETPELLEVRE KQAEIKDAAV ATNQSEPATE
QPVTQRTPMK GPINKQIETR TSDGKRRITP MFIPPAPDSG DVPLPFGASG SQQPTFSSSS
ETKSRIVIEK RDDIVTPNVS GSSNSRPCDA TSAIPTTPVV NSTSSQPPIS SQTVGQNRIT
SNTSDGRLEV QKVDRSVPTV VATKRRMDSA HGTGTKLPTV KRSRPPVATS SDKQLQPTSL
PQPSAKVGLP GVGDVDSGQG LKLPPLKLQD GKGFVVRISG GIGLHRNRCL EVENGAYGSS
FGSLTKVRMF SDGHSAGDMP GWEAVLGYPV CGSVANSQLV AIACEDATLH LLQTDTGQRP
LPPLVLSSPA SRLALNASQQ VMAVTCRGNV SVWDILKTKA LVRNESLLPV MQAEPGSTVT
ILSCSLTEEG HPIVSLSTGK AYMFSAELGN WLVLANSRDP VQRCSLHRAF VTTLPTSENT
RGLPLACLQS HVISGGNLLG QGSSVSALCT VTFLEQQLAA CRALNSKQEY HSWLLALARF
LVQEGLETRL RLICDDLLGP THSRAKNSKS WETSLMGFSK HALLREVLPL IGSNLRLQRI
YTEYSDQLAM LSEEK
//
