ID A0A2J7Q3P5_9NEOP Unreviewed; 1161 AA.
AC A0A2J7Q3P5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Protein lethal(2) giant larvae {ECO:0000313|EMBL:PNF23206.1};
GN ORFNames=B7P43_G02727 {ECO:0000313|EMBL:PNF23206.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF23206.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF23206.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF23206.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat L(2)GL family.
CC {ECO:0000256|ARBA:ARBA00008070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF23206.1}.
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DR EMBL; NEVH01019065; PNF23206.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7Q3P5; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR000664; Lethal2_giant.
DR InterPro; IPR013905; Lgl_C_dom.
DR InterPro; IPR013577; LLGL2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10241; LETHAL 2 GIANT LARVAE PROTEIN; 1.
DR PANTHER; PTHR10241:SF29; LETHAL(2) GIANT LARVAE PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF08596; Lgl_C; 1.
DR Pfam; PF08366; LLGL; 1.
DR PRINTS; PR00962; LETHAL2GIANT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 41..111
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 73..114
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 261..360
FT /note="Lethal giant larvae homologue 2"
FT /evidence="ECO:0000259|Pfam:PF08366"
FT REPEAT 431..445
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 780..973
FT /note="Lethal giant larvae (Lgl)-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08596"
FT REGION 630..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..665
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1008
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 126573 MW; 8CFC6974135A957E CRC64;
MLKFIRGKGQ QPSAERQKLQ RELFAFRKTV QHGFPHKPTA LAWDPALRLL AIGTATGSVK
VFGKPGVEFY GQHTNHDSSV TQLVFLPNEG RIVSLCDDNS LHLWEINEGC LEEVKSQALE
GKLKKISAVC LESACEHLLL GTEGGNIYLL NLKTFEMADT IIYQDVVMQN VPEDYKINPG
AVEAIAEQPG NPDRILIGYN RGLMVLWDRK TPGAEQTYIS TQQLESVCWH KSGSRFASSH
NDGSYAIWDA SVGERPSEEP TTVYGPFPCK AVTKLLWRHA KKDDYMVFAG GMPRASYSDR
HTITVQHGKR HVVFDFTSKV IDFFTVAIDP DDREFDEPEA LIVLLEEELL AIDLLADDWR
MLSLPYLVSL HASAVTCSQH ISGVPQDLWQ NIMLAGKKQT QDLYSDREWP VTGGKILGDA
TEGGEKASRE LLLTGHEDGT VRFWDASGIA LQPLYKFGSA QLFSGEEIAI EGSNGAPDEE
EDEDEWPPFR KVGAFDPYSD DPRLAVKKVA LCPMSGTLVV AGTAGSVIVA KINSDSVDKE
VEVTPMNIVL DRDGFVWKGH DQLTPRGGTL SFAPGFQPNS LFQLHPPAAI TALALHAEWG
LVAAGTAHGL ALFDYIRRKG VLTKCTLNPN DLSGAGDAPI SRRKSFKKSL RESFRRLRKG
RSTRQADKRG AHSTSPTAVT PTDPRKKDGL EEVAEDMAAE AGEEAAEGEV EAVEQRSSMG
AGDAVSSSSA GPGGLSPLEA KPVERQVEAR PVDDSLGSMV RCLYFAKTFL ITVQMMTATM
WAGTNNGTVF VFTVTIPSGA RRTEEDVSCQ LGKEIQLKHR APVIGIAVID GTNSPLPEPY
VTEKGSSKQQ DSPHRVVICS EEQFKIFTLP SLKPFCKFKL TAHEGARVRR MGIAQFTTAG
GQHSESCLVC LTNLGDCIVL SVPELRRQLN AAVIRREDIN GISSLTFTRR GQALYLHSSS
ELQRVTLSAT SITQPRCRLE LPDGARESAS GERDTDEEDE DTEDDEEERK IEGREVSAPS
PTAQEQQDSA PVVNGGTTDL EEGSDDKTDE PRENGMTGGT SDEDRHDMSA LSVGDITIDS
VKDHLFSTSG AEESRVSELK SSASSTMVTT TTATTEKLEQ QQQSVVVRTT TTVISSTTSG
TVTNETATVN STGHTPDIAV N
//
