ID A0A2J7QQ67_9NEOP Unreviewed; 858 AA.
AC A0A2J7QQ67;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 22-FEB-2023, entry version 11.
DE SubName: Full=DNA mismatch repair protein Msh2 {ECO:0000313|EMBL:PNF30713.1};
GN ORFNames=B7P43_G06082 {ECO:0000313|EMBL:PNF30713.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF30713.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF30713.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF30713.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF30713.1}.
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DR EMBL; NEVH01012087; PNF30713.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7QQ67; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965}.
FT DOMAIN 741..757
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 469..496
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 858 AA; 95409 MW; 843E824CFD8EC6BE CRC64;
MAVQPNQHLT VDAPQQKGFV NFFKSLPEKP ATTVRFFNRG DYFTLHGADA IFAAKEVFRS
AAVVKFIGAD NNRIESLALS KSNFESFVRD LLLVKQYRVE VYVTQGSGTK NSNDWTLEYK
GSPGNLVQFE DLLFSNVDLV VGTAVIAVRL AGNPKARVVG MGFADTTEWK LSVCEFPDDQ
HFSNLEALTV QLGPKEVLLP ITPESSVDMA EVKKVMERSS VLVTQRKKTE FSTDGLAQDL
NRLLLFMEGQ QHNSLALPEL NFTTATSSLA ALIKYLELGA DQGNFGQFTL TTLDHTRFVR
MDAAAIRALS LLPPPGSGAA NRNRSVLGLI DQCRTAQGHR LLAQWLKQPL RDRHAIAERH
DVVQVILQDT AMRQALRDEH LRRIPDLQAL SKKLGRKKAG LQDCYRIYQA VGRVPQLMQS
LDGHDDFPAL RCMFIEPLTD LLSDMQRFQD MVETTLDMDQ VDRGEFLVKP SFDDDLQELR
QMMDSLEERI KKQLTCAARD LGLEPNKTIK LESNAQMGYF LRVTLKEERV LRNNKNYETL
DTNKSGVRFH SPVLADLNSE YLRARSRYAE QQKAIVTEIV NIAAGYAGTL QQIGDVLACL
DVLANFAEVA VTAPKPFVRP TLHDEGAGML ILKQVRHPCL EVQDGTSFIA NDVYFKHGEC
TFQIITGPNM GGKSTYIRSV GIMALLAQIG SFVPCDEAEM SLVDAILARV GADDCQIKGM
STFMTEMVET AAIIRTATSN SLVIIDELGR GTSTYEGCGI AWAIAEHLAK EVKAFCLFAT
HFHELTQLAE EVATLRNLHV TAVTSEDSLT LLYQVMPGAC DQSFGIHVAE MARFPKHVIE
VSLLSQFTAM KFHNVTLT
//
