ID A0A2J7R2K5_9NEOP Unreviewed; 1330 AA.
AC A0A2J7R2K5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JUN-2023, entry version 16.
DE SubName: Full=DENN domain-containing protein 5B {ECO:0000313|EMBL:PNF35069.1};
GN ORFNames=B7P43_G09453 {ECO:0000313|EMBL:PNF35069.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF35069.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF35069.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF35069.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF35069.1}.
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DR EMBL; NEVH01007828; PNF35069.1; -; Genomic_DNA.
DR STRING; 105785.A0A2J7R2K5; -.
DR InParanoid; A0A2J7R2K5; -.
DR OrthoDB; 5398783at2759; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17677; RUN1_DENND5; 1.
DR CDD; cd17678; RUN2_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR PANTHER; PTHR46070:SF1; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 33..582
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 778..988
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 992..1100
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1171..1323
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 857..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 150621 MW; 397EA6DB50C041E2 CRC64;
MFRMNISVSS GTDRFVDYFV ICGLDLSSGL EPDRFAGDNL ESTPLDRSYK CQVLGHYPDA
VLWNPFDKNA VGMLCLPHGL QFRTQKHSLE PQFHSFVITR EDGHRSYGFS YVFYEEINNR
KICSAMQTLQ AMHLTELSSN QVGRSGRRGH SAGLGHDAHN TRSLPRHFKL STHQQGAAQS
YYDAAKDTLY VSKSIALICQ LPYVYAACKY LRGLHRLVST SSPGQLSIES YIHNLLYEVP
VPQPGRTVCF SCPLADSVVI QRPGSIEELP LFDFSLRELF TLLGVDCLTQ LFTCVLLEHQ
VLLCSSDYHR LMLVAESVTA LLFPFSWQHV YVPILPASLQ HFLDAPVPFV MGLHSCSESQ
LKIASEANLC YVDIDSQTIQ LPEELPSFPQ HAEFVGELRE LLMKHTVSSG QSVRNLNERI
VPHASSNMTS SCTLPGGFGQ LMRRKHSWSH NSDAGMSDAL QRIVAIVERT GVSLDDSGQV
NGTECKLSEH EQYVEDLRFN NAVREVFLNR FVYIFSAYEH FVIQPNQDKE QWLNNRDTMQ
NFDKATFLSD QPEQHLPFLS RFIESQMFAT LIDNKIMASW SEMEPNLRVF DRRIRLLRKR
FGEALVRTPG YEPCTTIRDT ELLLEKRLAS VDIVVASPQE VLQTAGPQQH SGVFPLLDPV
ALNKEPVHRS QKRKTMQWRT GHHCHHHQNI EQHEPVDGER TADTVGLLQR VSSTGISLRQ
PKLRNDMSPA RVAQTNWTFV ETLLKDCKSK TKRMLVEKMG TEAVELGHGS GESSLEGVEE
NTLIASLCDL LERIWSHGLQ KKQGKSALWS HLTNYQELKE CDDTSKPIDP NFLTPVLAWC
VLRKRLDYLS SMALETDLSP SSQRHGREGH KLPEGRSQIS SSPASLPPNS EQPNLRPLPV
SLTADMRNVQ AMTDIKTHIG YARAWVRLSL EKKLLSRHLR TLLSDSALLR SQYKRYAFLR
CEDEKEQFLY HLLTLNAVDY FCFTNTYTGT KLPYRVVIFP SRKTSAATTS ANSWVAVSGT
LGETSPVPIP RGALEFLFRH KNLGILTTLR IGHDNSGPSP KWMVEHVVVR NEVTGHTYKF
PCGRWLGRGI DDDSTERLLV GELVPRDVDS DELVETCRTP PPRCHSPSVP RRSQDARPSL
AEIQHMLGDA VNSIVKLLYH RKHDKERSTL TLLLCGETGL VYCLEQAFLT GFKSTRLFGR
NLYLWDYFLR AKEQFEATLL DSDGDMTPHP SEKQILHCYC NLVNQIGSTS HTLGKDGKFQ
LFVCLCAREH LLSRMLTPLS LCCVTLEMYE EQSFLRSPTL LTFLRQILES LDEFDIVLEN
SLTQGIGGTH
//
