ID A0A2J7R8W0_9NEOP Unreviewed; 749 AA.
AC A0A2J7R8W0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Coronin {ECO:0000256|RuleBase:RU280818};
DE Flags: Fragment;
GN ORFNames=B7P43_G00408 {ECO:0000313|EMBL:PNF37262.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF37262.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF37262.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF37262.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: F-actin regulator involved in anterograde Golgi to endosome
CC transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by
CC the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and
CC localizes to the trans-Golgi network, where it promotes actin
CC polymerization, thereby facilitating post-Golgi trafficking. May play a
CC role in the maintenance of the Golgi apparatus morphology.
CC {ECO:0000256|ARBA:ARBA00024838}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family.
CC {ECO:0000256|ARBA:ARBA00009482, ECO:0000256|RuleBase:RU280818}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF37262.1}.
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DR EMBL; NEVH01006721; PNF37262.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7R8W0; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10856; CORONIN; 1.
DR PANTHER; PTHR10856:SF20; CORONIN-7; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF08953; DUF1899; 2.
DR Pfam; PF00400; WD40; 4.
DR Pfam; PF16300; WD40_4; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM01166; DUF1899; 2.
DR SMART; SM01167; DUF1900; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280818};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..66
FT /note="DUF1899"
FT /evidence="ECO:0000259|SMART:SM01166"
FT REPEAT 75..109
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 125..166
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 167..199
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 485..550
FT /note="DUF1899"
FT /evidence="ECO:0000259|SMART:SM01166"
FT REPEAT 609..651
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 652..693
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 389..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 749
FT /evidence="ECO:0000313|EMBL:PNF37262.1"
SQ SEQUENCE 749 AA; 82678 MW; 281EF9660229EDF4 CRC64;
MAWRFKASKY KNAAPVVPKP EACIRDISVG SYQTYGNNIA ASAAFMAFNV DHNGSSLAVL
PIDDCGRKSK TMPLLHAHTD TVTDMDFSPF HDGLLATGSQ DCLVKLWHIP DKGLEESLYN
AECTFSHKQR RVETVCFHPT ADCLLTTTSY TTLTLWDISS EKEMLSNAEH SDVIQSLSWK
KDGTLLATSC KDKQVRILDP RLPANSFTHM ANSHQSIKDS RVVWLGDTGK ILTTGFDSGR
QREVFIRDLR NFEDCEKALV LDSSTGILIP LYDPDTGMLF LAGKGDTTIS YLEVTDREPY
LLEGIRHNGE QTKGACLVPK RSLAVMQGEV NRLLQLTSSS VIPIMYQVPR KSYRDFHADL
FPDTTGCEAQ LSAVQWLQGH NAPVPRISLD PAKRSAGESP IQPRLGPKPF TPPKLNFSSS
GSGDGDIKGT TEFSFDKVFS VPVAPGHEAM NGALNRHGNS FHTVDNENSG TNQNLSYIEN
DLQSKGGRVS KFRHLKGTSL HKSTHIENIR NVSRQISGEC DGFHANRERV AVPLSGPGGK
IAVFELSKTG KLPDGVIPTL VHGTNIMDFA WDPFNCKRLA VACDDGTIRL WLIPEMGLAE
PTNEPDTILA GHSEKIYFIK FHPLAKDVLA SGSYDMTVRI WDLATQEERI VLHGHTDQMF
SFAWSPCGAY CATVSRDSKL RVYKPRSNSQ PIREGKGPVG SRGARIIWAL EGRFIVVMGF
DKVSERQIQI FKADSLNLPL NTVGLDVSP
//
