ID A0A2J7RGC7_9NEOP Unreviewed; 875 AA.
AC A0A2J7RGC7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Ionotropic receptor 8a {ECO:0008006|Google:ProtNLM};
GN ORFNames=B7P43_G01962 {ECO:0000313|EMBL:PNF39889.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF39889.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF39889.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF39889.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF39889.1}.
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DR EMBL; NEVH01004401; PNF39889.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7RGC7; -.
DR STRING; 105785.A0A2J7RGC7; -.
DR InParanoid; A0A2J7RGC7; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13717; PBP2_iGluR_putative; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF403; IONOTROPIC RECEPTOR 8A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..875
FT /note="Ionotropic receptor 8a"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014410440"
FT TRANSMEM 513..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 377..779
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 387..457
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 875 AA; 99566 MW; BA25E1EB08DF74F8 CRC64;
MQIFLQIFFA FVFFPIAFTQ TSVKFLVLVE MQQEKLPGMY SQVMKEAQDK TGLIMDDITV
KINREEEEET FGRVCNEVMK GVTLILDLTW TGWGRCRQLS ESTGIPYIRA DATIGGFVQV
VDAYLTERKG TDAALIFQNE EELDQALYYL IGNSIIRVIV LDGLPGNSTD RLLAMRPVPS
YFVIFGDTEN VIKLFKKAQD GKLVTRSERW NLVFTDFLYD NFKQSSLNTL VSLITLDKDI
CCRLLDQDKG CACPDKFEIL PVYMKEVIMF LGDLLVEMKK SGSDLSRPAG EWGADCQNVD
AKTADNTTRD KFYELMPQVL VHHNALGFNQ SRWLLYYHND MEIVLANSSS RDRLAKWTMD
EGLSVKPNVT LAPTKRFFRV GTAEAIPWSY MKRNPSTKEI MRDAEGNILW EGYCIDLLQK
LSELMDFDYE IVPPANGEFG KRYPNGTWDG MVGDLAMGET DMVIAPLTMT SEREEVIDFV
APYFDQSGIS IVIRKPVRKT SLFKFMTVLR LEVWLSIVGA LTVTGIMIWI LDKYSPYSAQ
NNKALYPYPC REFTLKESFW FALTSFTPQG GGEAPKALSG RTLVAAYWLF VVLMLATFTA
NLAAFLTVER MKSPVASLEQ LARQSRINYT VVNNSDTHEY FQNMKNAEDV LYDVWKSITL
NSSSDQSKYR VWDYPIKEQY GHILQAITQT GPVENATVGF QKVIDQEEGK FAFIHDAAQI
RYEVSRNCNL TEVGEMFAEQ PYAIAVQQGS HLQEEISRKI LDLQKDRYFE TLSGKYWNSS
AKGDCPNNDD SEGITLESLG GVFIATLFGL ALAMITLAGE IFYYKRKKLT TISARQPVNE
PPKKQITIGK EFRPVMDKTM PRVSYISVFP RNQLY
//
