ID A0A2J7RMQ7_9NEOP Unreviewed; 4743 AA.
AC A0A2J7RMQ7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Obscurin {ECO:0000313|EMBL:PNF42112.1};
GN ORFNames=B7P43_G10279 {ECO:0000313|EMBL:PNF42112.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF42112.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF42112.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF42112.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF42112.1}.
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DR EMBL; NEVH01002552; PNF42112.1; -; Genomic_DNA.
DR STRING; 105785.A0A2J7RMQ7; -.
DR InParanoid; A0A2J7RMQ7; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 3.
DR CDD; cd13325; PH_unc89; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF8; WRAPPER_REGA-1_KLINGON HOMOLOG; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 21.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 20.
DR SMART; SM00408; IGc2; 19.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 21.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 19.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 290..400
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 418..596
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 608..716
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1163..1365
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1385..1448
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1463..1552
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1557..1640
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1649..1740
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1745..1835
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1840..1933
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2349..2438
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2448..2545
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2576..2639
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2645..2736
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2742..2832
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2840..2929
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2937..3027
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3041..3131
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3137..3230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3244..3333
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3360..3460
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3595..3684
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3714..3967
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 4180..4271
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4276..4370
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4424..4678
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 220..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3013..3040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4025..4053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3023..3040
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4743 AA; 532368 MW; D00D4BF16A5873A0 CRC64;
MDILRRLTVM RQLAEQRPSL CLALRLLQSD PEVARSDPRL RELVRESAAL MAVPKEQLPL
ESSKDIPSSL FHCNSILAME DFLLSRNQRS SGTLLILKQG LQAIIPRENA RAVLTGQIPY
TVLDESGIRH FEPLHVLSAL RLPRQAAYHF SIYSCPAAKE ESSCSAATVT SRSSCEDLGM
LDSCRRRSDT TTTSRRRGTL ESVDGSTLNY TRLNGDSDVH NVTSGYNTPT TKYGNRYSRR
YGSLNGDRSL SPPSGYGTPR CRPNGSGDNT YALGGRLSRS ASSVRMLGSE VSDVFVAAQN
FPADDVDAIS LKKGDVVEVL DTGPEPVKRL RLDPDLDLGA EVAALLDSSA ARHKLAIRPR
RKHADSRQVQ QEATRWLVRM YDDPSRQGWV PASLLERSRE EEVTEPADPI GPEVHGQRRE
AVVRELVETE EEFGRDLQLV VERYLKPLDS STVPRVVRDN KDLIFSNLKQ IADFHNTVLI
EGVKYYASEP RMLGRTFLRL ERDFDKHVAY CRDEPIAQEF LQENDAVRDY FEEHSQQLGD
DKSLSEHLKL PIQRINDYQL LLKELVKYSS RLGEDTSDLQ KALELMLGVP HRANDIKFIS
SIEGYHGNIH KLGRLLRHDW FTVSDRDGKC KERYLFLFKA RILICKVHHI ADDRSVFVLK
DIIRLPEVEV NDLKDNPYTF ELHHIVAGFG RYPITIRAHS DTVKPAWLKE IRQYASDLFA
LAEHDADDLR LQTPLGNNED KSEPTTPPPQ EPSKVQPPLK SAENCCETQE VSRELVKTVN
GLDPVQEPER AIEAVRKVPE QKAEPEIEVP KENIEPGLKT AEVKAELEVK DSKSKLESNI
KGFSNNKSEP EIKDPEEIVE PEIGFTEEKL YPEIKGHEKK PQSEVKATEE EPEPEVKVPE
NKSEPEIRAP EEKPEPEIRA SEKKLEPVTK VPEKKEGLEI EVSDKLEPEI RASEKNQVPE
IQPLEKKPET ANEVSEKKPA SGKLDPELEA VVKKLEPGIE VPEKKPELEV RAPETKQQPE
IIASEEEAEP EVKFLEKKSE PEIKVAEKNA EIAPNTQDKK PESAKRKEDK AVVSIASSQP
ANKKVKVNGF ESDTAMAHFQ SVTSVKEFSS EEVYMESSGT VMSSSASKSV RFESSSVQSA
SEETGGVSNV FKLTRSTSAD GRPVFTKTIE GSNLEPGQNA VFQCELTSDT PTSMTWLKDN
RPMEDRLADR VLISSQNDNT AFRLEVQHCL ESDSGVYTAR ATNAVGAATC TAQLVVQELS
EEEKKRRAEA NAPLFVVKLK DTELLENTYL RFMIKVKGQP NPTLKFFKEG KEISPNNERI
QIVTEKADKG FYELVIADVL PEDAGKYSCA ATNKYGEVSC EATVTVTSEK EIFKGLGSTL
LEPGEEAQFQ WLRDGQPFDP EERFKVLFKD DEDSLALVFQ HVKPEDAGLY TCVASTSTGR
ISCSAELTVQ GSVNQLAREP EVPKISTESK STEVGLGGSA MLELKVEGYP KPDIKWTKDG
NPVEAGGRVR FLYEDEESMS LIIKGVTADD AGKYKVVAKN ELGQDSTEMD LLVKAPPKIK
TELENSSCMT DQNMTFTVEV EGMPVPEVKW LKEGQQISQS DRIKIVKEKE THSLTIEKAR
LEDTGSYSIV AVNEISQTSS FWQFVVHSPP VILKNLNKKV EAKEDDTLCF DIKVQGDPKP
EVKWTKDGED LTADGKHITI SEDGQLHSLI IKNASRDDSG TIAAQVWNDH GWLKDTSEVN
VRCAPEFKRN LKDFTANEGD TNVEFNINVE AYPKPAVKWF LNDIEITEKK TEFTREEDEN
NYKLIIKKVT TDLAGKYECK VINDLGTIDT ACNFTVQYKP HFPKGLTNIE VDEGQELTLS
IQCSAVPEPT IKWFKDGQEV TADAHIKISR DSQSLENYYL TVTLVKGADA GDYEAKAENS
MGTATTKNTV KVNTLTKKKE VQEETVIYVQ NTPDDTEKKR QEGEELQELF SKKIIEEEIT
VEVMPHQGVQ AEVLEVQQPE RQSMSTVETQ SIMYSRGAGN GERTVTISVA SSTHQTAVFS
EDGLQGPEAI HTRVETSSTK VVCQQSAGGI LMEELEPGSF IMQGERNSAT LNNITPNTDE
LKDLRKKQGA EVLVEELLED GNFKFPVVQN MNSKLVGAVL IEEPTSDTDF DEHDIKRSKQ
LSVNRGVSIV SLTSDDEGSL KGSLSKDPSA EEAFPFNQCS PHDNLALKEL QKGKVIHVTS
CGVQNERLEI KSTTEEDEPQ KGKLADKTSA SEIRNDFKEA QVTCPAPEAK KGLKLDASTR
EEFSSSAQKP RMLLGEQVHE AIHQKGQRIA EENGDDPAIE ALLQRIQKQR SVLEEILEKE
EERKCEAVPQ IVGTDMDDRE IYESLCTAYE VRANGIPRPE AKWYHDGAEI TPSDRVKLSD
SGESYKLELK DAQLSDSGTY KCKIANRLGE KTHEAKLSLI SVNEFRKPKI TQPLSSVSVP
KNEPAVLALV LTADPLADVK WFHDDVELTE DEFHKFTLET KDVDDGLKEC TYTLTIPSGR
HKDTGQYRFT AKNKFGKDEC SARLDILLMP EIDGLKDSQR IPYEDIEFEV LILANPKPQV
VWTKDGEKIE NTEHTKITGD IEKEIYKLYI SNIGLRDHGT YTVTATNSQG ESSQTAKFHV
HTEPPSFLKN LEDQTVKDYD DVEFRVRVNG VPKPHIKWFK DGQELKSEGR LAVETDSEVL
VSSFINIKHF NESDVGKYSV TASNLVGQVE TSANLTMAQI PPSFGRPIDR AIEVDEGDIL
DIKTKLDGSP VPKAQWYKDG EELATSDHVK LTALPDGTVR LYIDNVLPAD CGAYRLVATN
KNGEATAICA VAVKPSNRKP AFVKPLEDAK SVVGQPLKLE AQVVAFPAPE IKWFKDGHPV
RPTQAINFVN QPGGIIGLHI DAVRPEDAGN YAVTVNNKLG DLTGAAKVTV EAREKKPSFQ
AGLQPSTVVE GFPARLEVKV IGHPPPTLKW TQNGKDIEPD GKSVKIVELP DGTTALVLEK
AKPEDAGDYE VTATNEKGSV SSRARLDVSD KGRGDAPEEK PAFIHGLRDA TTEEGDILLL
GAPFIGNPIP DVKWTKDGEP VTPSERIMLT CDGKKVGLEV KPARLSDAGS YVCQLKNPLG
EDESTAKASV RKVYQAPNFT QKFTDLQQLP TFDAKFPARV TGIPQPDVTW YFNDQLIVPG
TGAESDKYRV KRDGDAVCLY VRDCKPSDAG CYKCRASNCD GEASCEASLE VVDKIEKKQK
IEPPEFLKKI GDCEVYQGMT AKFTACASGY PEPEFEWFHD GQKIYPSDRI RMEREGSGLL
RLSIEGVDPS DVGKYKLRIF NPHGETSCEA DLSYDSLDSK PKRPVGDLYT DFDKFRKTGA
PLPLADRPII SRMTDRRLTL SWKPSIPIGP RVPVTYRVEM SEQPDGDWFT ARTGIRSCAC
DIHNLEPFRD YKFRVRVENK YGVSDPSPFA VTFREKLEPD PPKFFPYLQP GIDFRPETSP
YFPKDFDIEK PPHDGYAQAP RFLRQEHDTQ YGVKNHNCNL FWFVYGYPKP KMTYYFNDEL
IETGGRYDTS YTRNGQATLF INRMLDRDVG AYEAVATNEH GEARQKVKLE IAEYPEFIKR
PEETVIMTRK SGRIVARVTG VPYPEIKWYK DWQPVASSSR IKIQFIEPDT CILVINDAIN
KDEGLYSLSA RNIAGTVSSS VMVHVEESEQ EYGYLTYSKG RNIKPKSKPF EEQYDIGDEL
GRGTQGVTYH AVERLTGRNY AAKIMHGKSD LRPFMNNELE YLNLLNHPKI IRLHDAYETN
RTLTLITELA SGGELLDNLT KQTYITETDI AGYIRQVLWG LEHMHSQNIA HLGLTIGDLL
ISHPGGDDLK ICDFGLSRRI AFGKLAALDY GMPEFVAPEV VNGDGVGLGA DLWSVGVITY
LLLSGHSPFR GPNDRETLTR VKEGKYDLRF EWFSGISAEA KDFIQKLLVY NADGRMDVKT
ALKHPWLQVA DKIPVDQYKI GTENLKNYYN RYRDWYHNAS CRTWFRRRPL SGAFTHPSKM
VYPPGHIYTP EPTPEPTPKE PKEPRTWEAQ LPPRPPLDYE IGSVKSESHY QYGPDTYLLQ
LRDVDFPVRL REYMKVAANR GPVVGAHDNI DWRTPVIRER RRFTDVMDEE IDDERKERIN
QYGSSDVYSL RRLRRELGTR LDGHAEAEAL IEYKREGQPP FFREKPQILP IVDDQPAELV
CFAVGDPKPS VQWFKNDLVI TESHRVKILE DAEGRSLLRF DPASNVDVGI YKVVARNKVG
QTQARTRLVL ASVPSAPDSP DVAEVSDTEV LLKWKQPKDD GNSAVLCYNL QYKEADSVEW
LDVANNIDHE FYVIHNLRPS VTYQFRLAAR NRIGWSEKGI PTPLVRTKEA GAPKVPVTRA
MKHLQEITES GQEITADEPV THLDYSAEKT PIEWISEGAL NEKYSFVSEL SRGRFSVVVK
GIEKASDRVI VAKLLELRPE TEAKVTREFE ALRSFRHERI ATLLAAYKPP GSAVAVLVQE
KLQGADILTY FSSRHEYTEQ MVATVITQIL DGLQYLHWRG YCHLNLQPDN IVMASVRSVQ
IKLVDFGFAQ RVSKLGTVTD AVGDSEYSAP EVLNNEPAFP QTDIWSVGVV MYILLSGISP
FRGTDSEETR QNVTFVRYRF EYLYKELTQE ATRFLILVFK RAPGKRPTAE ECHEHRWLLP
TEFMIKKRER AVFLGSRLKD FSEEYHSHRA KGATKSESLT GAFGGPKSLV RSSSIQEELL
TTF
//
