ID A0A2J7RPP3_9NEOP Unreviewed; 1187 AA.
AC A0A2J7RPP3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=CD109 antigen {ECO:0008006|Google:ProtNLM};
GN ORFNames=B7P43_G13621 {ECO:0000313|EMBL:PNF42789.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF42789.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF42789.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF42789.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF42789.1}.
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DR EMBL; NEVH01001358; PNF42789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7RPP3; -.
DR STRING; 105785.A0A2J7RPP3; -.
DR InParanoid; A0A2J7RPP3; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF179; LD23292P; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 84..221
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 364..455
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1041..1132
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT DISULFID 309..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 321..336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1187 AA; 135807 MW; 48BC02D984F79F5A CRC64;
MDKHLTSANL GDNEWNGSRR YTAEYADILS VERYWKEGVL YFKFDVPPKV LELTLRAFYE
DSEGESMQAK INIMQHYSPS KKYISVRTNS ADVEVGEFAV FHVKTNFILQ RFQYMVLAKG
LLLFADEHIV ESPVPTTTTF TIPIDTNMAP GFTLLVYHVT LHAELVADSV FVPVTGFNGF
EITLVVNQGK DHTKKTAQAV MTAKAGAFMG INSVRSTAYF MQAGNDINRS RVTESFYAFE
NFTRAEPKVK WRSRQGLLPD EVSYFSRMSY GKNSYETLTF SGVVIFTDAY LPIRKLTDSC
HEKKGYKPCF SEGCFLSTKM CDGYNDCADW SDESDCPLQD DDQYEYRILR MSRSDELYDT
AGNDWSWKEM NADFGGEEFF TMDMPAVADE WYFTGFTLSR IRGFTTINTP IAFSSTRPFM
MHIEGPTMCR RGEQIGLRLL LLNNEPYEMF VVLTLHTSPQ YKFVHVEEGG IVTSYGARLS
GGDHQHLVYL PAGAQQHVDM PIAPVVEQGD ISVTISAMTQ VGRIELVHNI TVLGEGAMVN
KHTAVYLDLK NKALVLQYLD IYVEESPIVP YQSWRRYVYG STSGYITITG DIIGPAFPAV
PLTTGVVLGR EIKGTDGRIF ELAVNVWTLH YLRLTNQLKW DITKQVLEEV NVIFGQVMKR
FDRRGWFKNW DNSQPSVWLT SWAIRIFKHA SFQDWENFFY IEPQIITRSI EWILQFQTEL
GSFEETTWYH NPLDATMQGK FSTRFNDSLV YRNITLTAHI LITIHEVMQM VQGSTRTDAA
KASIKAVRYL EHQLSSMTDP YEIAITAYAL TLCDSIEKEF AFSLLHSKRL EVADGLQYWS
RVPVPGNTIR YENQRPFICP RDYQTDDSVA VEATSYALMV NLMRDGVTVL SEKIVQWLTS
VRMGSSAFIS TVDTVIALQA LTEYAFRARL KDITDLAITL ELPSTAGFRE TVHIDNETFS
DLQMFEVPNV WGHLNVISKG SGQAVVQMDI NFGVDYEGFR ELAIIETFNL EVKEFYSSFR
NKSFITIQSC FRWLLEDPPM SGLSVLELEL PTGYNLLESE AERLVRSGVH PTLRDARIIE
GKTFWFFEHI MQNWTCFNHT VRRWYPVANI SLVRQVQLYE THAKENFIMI LVNSTPLYTL
NICEVCGSYQ CPYCPYYSQT APFSASKFIT VVLLITSQIL KTFRQFT
//
