ID A0A2J7RQS3_9NEOP Unreviewed; 851 AA.
AC A0A2J7RQS3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=B7P43_G15657 {ECO:0000313|EMBL:PNF43173.1};
OS Cryptotermes secundus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Kalotermitidae; Cryptotermitinae; Cryptotermes.
OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF43173.1, ECO:0000313|Proteomes:UP000235965};
RN [1] {ECO:0000313|EMBL:PNF43173.1, ECO:0000313|Proteomes:UP000235965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:PNF43173.1};
RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T.,
RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J.,
RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C.,
RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M.,
RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M.,
RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G.,
RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J.,
RA Bornberg-Bauer E.;
RT "Hemimetabolous genomes reveal molecular basis of termite eusociality.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNF43173.1}.
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DR EMBL; NEVH01000618; PNF43173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J7RQS3; -.
DR STRING; 105785.A0A2J7RQS3; -.
DR InParanoid; A0A2J7RQS3; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000235965; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF550; TOLL-9, ISOFORM A; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 6.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..851
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014380298"
FT TRANSMEM 637..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 693..837
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 851 AA; 96716 MW; CC62AAA2D73B8117 CRC64;
MVQAWWFPGL WAVLLVRAER VPQWVGNVLA PTDEVPSVPL DCQDAECICS EVPGKLVVCD
GGSGCKQFPS GLNTTAPVVQ VQNTGITTLQ NGDLANLTHL EELEIDHNNN LSVIKPWTFE
GLSSLRNLSI SYNENLTYLE AGVFGSLHSL RELRMKKDGF FDMGLIAPAL GPSSLPNLQK
LILDENPFQK IESKDLVPMN GSSLQRLHLI ACQLEFIHPS ALVPLRHLRA LLLGQNTLNS
STITELVSHL TDEGIPLYLL NLYGMGFLKR PPTDLMEAVS KSNITHLVLA RNQFQKLKPG
SFPTMPQLQY LDLREIVATD LKPGTLSPRV MPKLKTLLFG GNMLPGVIPG VLVPQLESLD
LSANYGDPRT RSYFDIGEGS FENMTNLSFL NLSYNNLRRI SRQTFTGLEN LSRHLGLKNA
SIYHLEEGSF ENLGKLKFLN LEYNPFPKLY NLTAAMFRGL HNLRVLLLSG CSISFLPSDV
FSYLPNLEYL ILRDNHLSTL SPILFAPLTH LIGIDLSDNQ LAYTKNTSYR LFENNSELEV
VFLSRNKFTS LNPFMLEDAA FLTRLELYDN NLLCQCAPFL STKKWLKEHN FTLEDMHIAG
LSTLPCFSPD EWMNKPVVEY IDSLTDSCLL PPGEDRALIW IMVLLVMFLV LSSLLATVAY
YYRSYIRYWI FIARMDIRRL GLRRQDCEGY KEHQYDAFVS YSNEDRNFVV RLVAMLENYE
PFLKLCVYER DFEIGAVISE SVLQSVALSR RTLLVISDAF ARSQWCRWEL QLAEHHRLFL
RDDNEGGDPL IMIKLGQVAE AHMTPTLRYL LRTRIYLEWD SEPRKQRQFW DKLRTALAPP
PVSIATTTNT Q
//
