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Database: UniProt
Entry: A0A2J8CEF4_VERDA
LinkDB: A0A2J8CEF4_VERDA
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ID   A0A2J8CEF4_VERDA        Unreviewed;      1062 AA.
AC   A0A2J8CEF4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN   ORFNames=BJF96_g1225 {ECO:0000313|EMBL:PNH35391.1}, VDGE_01211
GN   {ECO:0000313|EMBL:RXG43612.1};
OS   Verticillium dahliae (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=27337 {ECO:0000313|EMBL:PNH35391.1, ECO:0000313|Proteomes:UP000236305};
RN   [1] {ECO:0000313|EMBL:PNH35391.1, ECO:0000313|Proteomes:UP000236305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12008 {ECO:0000313|EMBL:PNH35391.1,
RC   ECO:0000313|Proteomes:UP000236305};
RA   Fan R., Armitage A.D., Cascant-Lopez E., Sobczyk M., Cockerton H.M.,
RA   Harrison R.J.;
RT   "Comparative genomics yields insights into virulence evolution of
RT   Verticillium dahliae.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:RXG43612.1, ECO:0000313|Proteomes:UP000288725}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Getta Getta {ECO:0000313|EMBL:RXG43612.1,
RC   ECO:0000313|Proteomes:UP000288725};
RA   Gardiner D.M.;
RT   "Genome of Verticillium dahliae isolate Getta Getta.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC       of transcription elongation, and plays a role in pre-mRNA processing.
CC       This complex seems to be important for the stability of the RNA
CC       polymerase II elongation machinery on the chromatin template but not
CC       for the inherent ability of this machinery to translocate down the
CC       gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC   -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC       polymerase II. {ECO:0000256|ARBA:ARBA00025870}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR036945}.
CC   -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC       ECO:0000256|PIRNR:PIRNR036945}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNH35391.1}.
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DR   EMBL; MPSH01000003; PNH35391.1; -; Genomic_DNA.
DR   EMBL; RSDZ01000102; RXG43612.1; -; Genomic_DNA.
DR   OMA; VGYMNTP; -.
DR   OrthoDB; 24955at2759; -.
DR   Proteomes; UP000236305; Unassembled WGS sequence.
DR   Proteomes; UP000288725; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006354; P:DNA-templated transcription elongation; IEA:InterPro.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd06081; KOW_Spt5_1; 1.
DR   CDD; cd06082; KOW_Spt5_2; 1.
DR   CDD; cd06083; KOW_Spt5_3; 1.
DR   CDD; cd06084; KOW_Spt5_4; 1.
DR   CDD; cd06085; KOW_Spt5_5; 1.
DR   CDD; cd09888; NGN_Euk; 1.
DR   Gene3D; 2.30.30.30; -; 3.
DR   Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR041973; KOW_Spt5_1.
DR   InterPro; IPR041975; KOW_Spt5_2.
DR   InterPro; IPR041976; KOW_Spt5_3.
DR   InterPro; IPR041977; KOW_Spt5_4.
DR   InterPro; IPR041978; KOW_Spt5_5.
DR   InterPro; IPR005100; NGN-domain.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR039385; NGN_Euk.
DR   InterPro; IPR014722; Rib_uL2_dom2.
DR   InterPro; IPR039659; SPT5.
DR   InterPro; IPR024945; Spt5_C_dom.
DR   InterPro; IPR022581; Spt5_N.
DR   InterPro; IPR017071; TF_Spt5_eukaryote.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR   PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR   Pfam; PF12815; CTD; 2.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   Pfam; PF11942; Spt5_N; 1.
DR   PIRSF; PIRSF036945; Spt5; 1.
DR   SMART; SM01104; CTD; 1.
DR   SMART; SM00739; KOW; 5.
DR   SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288725};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR036945}.
FT   DOMAIN          316..344
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   DOMAIN          476..503
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   DOMAIN          529..557
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   DOMAIN          652..677
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   DOMAIN          744..771
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   DOMAIN          846..1025
FT                   /note="Spt5 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01104"
FT   REGION          1..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          802..921
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          992..1062
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..101
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1062 AA;  113789 MW;  13CEF631C9310EA7 CRC64;
     MASNYNQFDD SDDDEAFNPA PADVSDDENA NGDADHQRSD ARDHSPAHDD EEEESPVAAK
     SGSRAVNDDE AEEDEDDEDD QPRGRAGDDD EDDEDDEDDE DDVQQGHRRK RHRDRRAAFF
     DIEAEVDDEE DGEDDEKDGE EIGDFIDNEH PDDVVDTGRL NDDRRHRELD RQRELESSMD
     AEKQAEILRQ RYGNRRAAKG FGDSTVVPKR LLMPSVDDPT IWAVRCKEGK EREVVFSIQK
     RIQERMGTKE EMAIISAFER GGTNSVMKGY IYVEAARSGD IMAALDGMLN VYPRSKLILV
     EIKDRPDLLR VTKTATLEPG AWVRLKRPQK HAGDLGQVVD VTESGLEARV RFIPRLDYGV
     RDDSATQITA DGKRKRPVGM PGPRPPQRLF NEAEARKRHP RFIQGNPQTK IWTYMGDDFE
     NGFQVKEYKI QQLVVTDVNP TLEEVTRFAS GAEDGTENLD LKALAASLKD SNTNVTYLPG
     DVIEVYEGEQ KGVVGRATTV SGDIVTLEVI EGVLAGQVIE VPTKGLRKRF KEGDHVKVIG
     GSRFRDEVGM VVKIQDDRVT FVTDQTNMEV TVFSKDVREA SDMGGQGSLG QYSLLDLVQL
     DPTTVGCIVK VDRESVAVLD QNGDARQVVP SQITNKLPQR KIAVAADRNG SEIRLDDVVR
     EWGGQQRQGK IIHIYRSYIY LHSHDNKENA GVFVTRAGNV TTIAAKGGRV VPSGPNLDQM
     NPAMKRLPAG SDGKMAPPKS FGRDRALGQT VIIKKGGYKG LLGIVKDTTE THARVELHTK
     SKTVSVPKDH LSYKDKNTGA VIDIGGRGGR GRGGGFGSGG GRGGGDSGWQ GGRTPMAGTE
     RTPAWGSRTP AANHGGRTPA WKSSGSGDLG SRTPAWADGS RTAYGGDGSR TAYGSGNRTP
     AWQSGARTPA PGGDAFGLGS RTPAYGADTW GSGSKTPAYG GASAPTPAAS GGDSWGGYSA
     SAAYDAPTPG AGLSAPTPGA LNAPTPGAYS APTPGAVNAP TPGGWAGGWG GADAAPTPAA
     AAPTPAASGF SSGAGYYSAP TPAAYGAPET PAASGPRYTD DD
//
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