ID A0A2J8KPC0_PANTR Unreviewed; 344 AA.
AC A0A2J8KPC0; A0A2I3STW5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sex hormone-binding globulin {ECO:0000256|ARBA:ARBA00040510};
DE AltName: Full=Sex steroid-binding protein {ECO:0000256|ARBA:ARBA00041855};
DE AltName: Full=Testis-specific androgen-binding protein {ECO:0000256|ARBA:ARBA00041528};
GN Name=SHBG {ECO:0000313|Ensembl:ENSPTRP00000080010.1,
GN ECO:0000313|VGNC:VGNC:9607};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000080010.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000080010.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000080010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an androgen transport protein, but may also be
CC involved in receptor mediated processes. Each dimer binds one molecule
CC of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
CC 17-beta-estradiol. Regulates the plasma metabolic clearance rate of
CC steroid hormones by controlling their plasma concentration.
CC {ECO:0000256|ARBA:ARBA00037620}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; AACZ04040209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016786955.1; XM_016931466.1.
DR AlphaFoldDB; A0A2J8KPC0; -.
DR Ensembl; ENSPTRT00000097663.1; ENSPTRP00000080010.1; ENSPTRG00000008700.6.
DR GeneID; 455215; -.
DR CTD; 6462; -.
DR VGNC; VGNC:9607; SHBG.
DR GeneTree; ENSGT00940000154035; -.
DR OrthoDB; 5316510at2759; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000008700; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24040:SF3; SEX HORMONE-BINDING GLOBULIN; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665}.
FT DOMAIN 1..159
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
SQ SEQUENCE 344 AA; 37434 MW; 30087C9374E2B2F2 CRC64;
MTFDLTKITK TSSSFEVRTW DPEGVIFYGD TNPKDDWFML GLRDGRPEIQ LHNHWAQLTV
GAGPRLDDGR WHQVEVKMEG DSVLLKVDGE EVLCLRQVSG PLTSKRHPIM RIALGGLLFP
ASNLRLPLVP ALDGCLRRDS WLDKQAEISA SAPTSLRSCD VESNPGIFLP PGTQAEFNLR
DIPQPHAEPW AFSLDLGLKQ AAGSGHLLAL GTPENPSWLS LHLQDQKVVL SSGSGPGLDL
PLVLGLPLQL KLSMSRVVLS QGSKMKALAL PPLGLAPLLN LWAKPQGRLF LGALPGEDSS
TSFCLNGLWA QGQRLDVDQA LNRSHEIWTH SCPQSPGNGT DASH
//
