ID A0A2J8NUT0_PANTR Unreviewed; 555 AA.
AC A0A2J8NUT0; H2Q217;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Perforin 1 {ECO:0000313|Ensembl:ENSPTRP00000004496.3};
GN Name=PRF1 {ECO:0000313|Ensembl:ENSPTRP00000004496.3,
GN ECO:0000313|VGNC:VGNC:7254};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000004496.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000004496.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000004496.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR EMBL; AACZ04041174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001171235.1; XM_001171235.5.
DR AlphaFoldDB; A0A2J8NUT0; -.
DR STRING; 9598.ENSPTRP00000004496; -.
DR PaxDb; 9598-ENSPTRP00000004496; -.
DR Ensembl; ENSPTRT00000004875.4; ENSPTRP00000004496.3; ENSPTRG00000002595.4.
DR GeneID; 450512; -.
DR KEGG; ptr:450512; -.
DR CTD; 5551; -.
DR VGNC; VGNC:7254; PRF1.
DR GeneTree; ENSGT00530000063725; -.
DR InParanoid; A0A2J8NUT0; -.
DR OMA; LCKNALQ; -.
DR OrthoDB; 4221421at2759; -.
DR TreeFam; TF330498; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002595; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0044194; C:cytolytic granule; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140911; F:pore-forming activity; IEA:InterPro.
DR GO; GO:0022829; F:wide pore channel activity; IBA:GO_Central.
DR GO; GO:0002357; P:defense response to tumor cell; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0140507; P:granzyme-mediated programmed cell death signaling pathway; IEA:Ensembl.
DR GO; GO:0002418; P:immune response to tumor cell; IEA:Ensembl.
DR GO; GO:0001771; P:immunological synapse formation; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0051712; P:positive regulation of killing of cells of another organism; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:0017038; P:protein import; IEA:Ensembl.
DR GO; GO:0009306; P:protein secretion; IEA:Ensembl.
DR GO; GO:0071806; P:protein transmembrane transport; IEA:Ensembl.
DR GO; GO:0001913; P:T cell mediated cytotoxicity; IBA:GO_Central.
DR CDD; cd04032; C2_Perforin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR037300; Perforin-1_C2.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF3; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..555
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015082623"
FT DOMAIN 27..375
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 397..519
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 555 AA; 61295 MW; C5C6B5DEB3058FD8 CRC64;
MAARLLLLGI LLLLLPLPVP APCHTAARSE CKRSHKFVPG AWLAGEGVDV TSLRRSGSFP
VDTQRFLRPD GTCTLCENAL QEGTLQRLPL ALTNWRAQGS GCQRHVTRAK VSSTEAVARD
AARSIRNDWK VGLDVTPKPT GNVHVSVAGS HSQAANFAAQ KTHQDQYTFS TDTVECRFYS
FHVVHTPPLH PDFKRALGDL PRHFNASTQP AYLRLISNYG THFIRAVELG GRISALTALR
TCELALEGLT DNEVEDCLTV EAQVNIGIHG SISAEAKACE EKKKKHKMTA SFHQTYRERH
SEVVGGHHTS INDLLFGIQA GPEQYSAWVN SLPGSPGLVD YTLEPLHVLL DSQDPRREAL
RRALSQYLTD RARWRDCSRP CPPGRQKSPR DPCQCVCHGS AVTTQDCCPR QRGLAQLEVT
FIQAWGLWGD WFTATDAYVK LFFGGQELRT STVWDNNNPV WSVRLDFGDV LLVTGGPLRL
QVWDQDSGGD DDLLGTCDQA PKSGSHEVRC NLNHGHLKFR YHARCLPHLG GGTCLDYVPQ
MLLGEPPGNR SGAVW
//
