ID A0A2J8P7X9_PANTR Unreviewed; 519 AA.
AC A0A2J8P7X9; A0A2I3T0A6;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit alpha2delta 3 {ECO:0000313|Ensembl:ENSPTRP00000082689.1};
GN Name=CACNA2D3 {ECO:0000313|Ensembl:ENSPTRP00000082689.1,
GN ECO:0000313|VGNC:VGNC:7961};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000082689.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000082689.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000082689.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR EMBL; AACZ04000334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2J8P7X9; -.
DR SMR; A0A2J8P7X9; -.
DR Ensembl; ENSPTRT00000101956.1; ENSPTRP00000082689.1; ENSPTRG00000015031.6.
DR VGNC; VGNC:7961; CACNA2D3.
DR GeneTree; ENSGT00940000155766; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015031; Expressed in Brodmann (1909) area 10 and 19 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF25; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-3; 1.
DR Pfam; PF13768; VWA_3; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 162..344
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 519 AA; 59527 MW; 198D13AF246286C6 CRC64;
MEEMFHKKSE AVRRLVEAAE EAHLKHEFDA DLQYEYFNAV LINERDKDGN FLELGKEFIL
APNDHFNNLP VNISLSDVQV PTNMYNKDPA IVNGVYWSES LNKVFVDNFD RDPSLIWQYF
GSAKGFFRQY PGIKWEPDEN GVIAFDCRNR KWYIQAATSP KDVVILVDVS GSMKGLRLTI
AKQTVSSILD TLGDDDFFNI IAYNEELHYV EPCLNGTLVQ ADRTNKEHFR EHLDKLFAKG
IGMLDIALNE AFNILSDFNH TGQGSICSQA IMLITDGAVD TYDTIFAKYN WPDRKVRIFT
YLIGREAAFA DNLKWMACAN KGFFTQISTL ADVQENVMEY LHVLSRPKVI DQEHDVVWTE
AYIDSTLTDD QGPVLMTTVA MPVFSKQNET RSKGILLGVV GTDVPVKELL KTIPKYKLGI
HGYAFAITNN GYILTHPELR LLYEEGKKRR KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT
GKFSMEVKKT VDKGFRCGAF QRSWEIFLPR ECNHRRRPA
//
