ID A0A2J8PJE5_PANTR Unreviewed; 456 AA.
AC A0A2J8PJE5; A0A2I3S9Q0;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Protein numb homolog {ECO:0000256|PIRNR:PIRNR017607};
GN Name=NUMB {ECO:0000313|Ensembl:ENSPTRP00000073556.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000073556.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000073556.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000073556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR017607};
CC Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR017607};
CC Cytoplasmic side {ECO:0000256|PIRNR:PIRNR017607}.
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DR EMBL; AACZ04008424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2J8PJE5; -.
DR Ensembl; ENSPTRT00000095462.1; ENSPTRP00000073556.1; ENSPTRG00000006513.6.
DR GeneTree; ENSGT00940000156005; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006513; Expressed in lung and 21 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF5; PROTEIN NUMB HOMOLOG; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607}; Membrane {ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 37..173
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 214..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..283
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 50182 MW; B079D49CE8B5DD53 CRC64;
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKGT EWGQSSGAAS PGLFQAGHRR
TPSEADRWLE EVSKSVRAQQ PQASAAPLQP VLQPPPPTAI SQPAPPFQGN AFLTSQAVPV
GVVPALQPAF VPAQSYPVAN GMPYPAPNVP VVGITPSQMV ANVFGTAGHP QAAHPHQSPS
LVRQQTFPHY EASSATTSPF FKPPAQHLNG SAAFNGVDDG RLASADRHTE VPTGTCPVDP
FEAQWAALEN KSKQRTNPSP TNPFSSDLQK TFEIEL
//
