ID A0A2J8PQH5_PANTR Unreviewed; 563 AA.
AC A0A2J8PQH5; A0A2I3TF26;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nitric oxide synthase trafficking {ECO:0000313|Ensembl:ENSPTRP00000087864.1};
GN Name=NOSTRIN {ECO:0000313|Ensembl:ENSPTRP00000087864.1,
GN ECO:0000313|VGNC:VGNC:14321};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000087864.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000087864.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000087864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04058503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04058504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04058505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04058506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04058507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009441916.1; XM_009443641.2.
DR AlphaFoldDB; A0A2J8PQH5; -.
DR STRING; 9598.ENSPTRP00000087864; -.
DR Ensembl; ENSPTRT00000082326.1; ENSPTRP00000087864.1; ENSPTRG00000012604.6.
DR GeneID; 459712; -.
DR CTD; 115677; -.
DR VGNC; VGNC:14321; NOSTRIN.
DR GeneTree; ENSGT00510000048120; -.
DR InParanoid; A0A2J8PQH5; -.
DR OrthoDB; 5400939at2759; -.
DR Proteomes; UP000002277; Chromosome 2B.
DR Bgee; ENSPTRG00000012604; Expressed in lung and 20 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11823; SH3_Nostrin; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR035656; Nostrin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065:SF62; NOSTRIN, ISOFORM H; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 2.
DR SUPFAM; SSF46585; HR1 repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..317
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 349..429
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 495..554
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 363..433
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 563 AA; 64436 MW; 6FE53187E5DD4D54 CRC64;
MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQRAN LEISYAKGLQ KLASKLSKAL
QNTRKSCVSS AWAWASEGMK STADLHQKLG KAIELEAIKP TYQVLNVQEK KRKSLDNEVE
KTANLVISNW NQQIKAKKKL MVSTKKHEAL FQLVESSKQS MTEKEKRKLL NKLTKSTEKL
EKEDENYYQK NMAGYSTRLK WENTLENCYQ VTHSICLYAF WVKRAWGKCV SDLRYQDTFL
PGNLPPLWFG YDIVKRLIMR LCSVCLQSIL ELEKERIQLL CNNLNQYSQH ISLFGQTLTT
CHTQIHCAIS KIDIEKDIQA VMEETAILST ENKSEFLLTD YFEEDPNSAM DKERRKSLLK
PKLLRLQRDI EKASKDKEGL ERMLKTYSST SSFSDAKSQK DTAALMDENN LKLDLLEANS
YKLSSMLAEL EQRPQPSHPC SNSIFRWREK EHTHSYVKIS RPFLMKRLEN IVSKASSGGQ
SNPGSSTPAP GAAQLSSRLC KALYSFQARQ DDELNLEKGD IVIIHEKKEE GWWFGSLNGK
KGHFPAAYVE ELPSNAGNTA TKA
//
