ID A0A2J8QA68_PANTR Unreviewed; 749 AA.
AC A0A2J8QA68; H2QQT1;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DAB adaptor protein 2 {ECO:0000313|Ensembl:ENSPTRP00000028835.6};
GN Name=DAB2 {ECO:0000313|Ensembl:ENSPTRP00000028835.6,
GN ECO:0000313|VGNC:VGNC:9063};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000028835.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000028835.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000028835.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04037939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016808859.1; XM_016953370.1.
DR AlphaFoldDB; A0A2J8QA68; -.
DR Ensembl; ENSPTRT00000031218.6; ENSPTRP00000028835.6; ENSPTRG00000016817.7.
DR VGNC; VGNC:9063; DAB2.
DR GeneTree; ENSGT00940000155567; -.
DR OrthoDB; 2913989at2759; -.
DR TreeFam; TF316724; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000016817; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd01215; PTB_Dab; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR048559; DAB1/2_SBM.
DR InterPro; IPR048561; Dab_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47695:SF5; DISABLED HOMOLOG 2; 1.
DR PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21792; DAB2_SBM; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 45..196
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..608
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 80266 MW; 643466BB7C6D81E1 CRC64;
MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY KAKLIGIDDV
PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK
ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK
KIEEASKAVE NGSEALMILD DQTNKLKSES KDILLVDLNS EIDTNQNSLR ENPFLTNGIT
SCSLPRPKPQ ASFLPENAFS ANLNFFPTPN PDPFRDDPFT QPDQSTPSSF DSLKSPDQKK
ENSSSSSTPL SNGPLNGDVD YFGQQFDQIS NRTGKQEAQA GPWPFSSSQT QPAVRTQNGV
SEREQNGFSV KSSPNPFVGS PPKGLSIQNG VKQDLESSVQ SSPHDSIAII PPPQSTKPGR
GRRTAKSSAN DLLASDIFAP PVSEPSGQAS PTGQPTALQP NPLDLFKTSA PAPVGPLVGL
GGVTVTLPQA GPWNTAPLVF NQSPSMAPGA MMGGQPSGFS QPVIFGTSPA VSGWNQPSPF
AASTPPPVPV VWGPSASVAP NAWSTTSPLG NPFQSNIFPA PAVSTQPPSM HSSLLVTPPQ
PPPRAGPPKD ISSDAFTALD PLGDKEIKDV KEMFKDFQLR QPPAVPARKG EQTSSGTLSA
FASYFNSKVG IPQENADHDD FDANQLLNKI NEPPKPAPRQ VSLPVTKSTD NAFENPFFKD
SFGSSQASVA SSQPVSSEMY RDPFGNPFA
//
