ID A0A2J8UA48_PONAB Unreviewed; 322 AA.
AC A0A2J8UA48; A0A6D2VTI8; H2P011;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=MYADM isoform 2 {ECO:0000313|EMBL:PNJ42145.1};
DE SubName: Full=MYADM isoform 5 {ECO:0000313|EMBL:PNJ42148.1};
DE SubName: Full=MYADM isoform 6 {ECO:0000313|EMBL:PNJ42149.1};
DE SubName: Full=MYADM isoform 7 {ECO:0000313|EMBL:PNJ42150.1};
DE SubName: Full=MYADM isoform 8 {ECO:0000313|EMBL:PNJ42151.1};
DE SubName: Full=Myeloid associated differentiation marker {ECO:0000313|Ensembl:ENSPPYP00000011608.1};
GN Name=MYADM {ECO:0000313|Ensembl:ENSPPYP00000011608.1};
GN ORFNames=CR201_G0029984 {ECO:0000313|EMBL:PNJ42145.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011608.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011608.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ42145.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ42145.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000011608.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000256|ARBA:ARBA00034721}.
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DR EMBL; NDHI03003467; PNJ42145.1; -; Genomic_DNA.
DR EMBL; NDHI03003467; PNJ42148.1; -; Genomic_DNA.
DR EMBL; NDHI03003467; PNJ42149.1; -; Genomic_DNA.
DR EMBL; NDHI03003467; PNJ42150.1; -; Genomic_DNA.
DR EMBL; NDHI03003467; PNJ42151.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000012052.2; ENSPPYP00000011608.1; ENSPPYG00000010364.2.
DR Ensembl; ENSPPYT00000035109.1; ENSPPYP00000043292.1; ENSPPYG00000010364.2.
DR GeneTree; ENSGT00950000182933; -.
DR OMA; GGMADWC; -.
DR OrthoDB; 3818412at2759; -.
DR TreeFam; TF331088; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0061028; P:establishment of endothelial barrier; IEA:Ensembl.
DR GO; GO:0031579; P:membrane raft organization; IEA:Ensembl.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090038; P:negative regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0044860; P:protein localization to plasma membrane raft; IEA:Ensembl.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR047123; MYADM-like.
DR PANTHER; PTHR17068:SF3; MYELOID-ASSOCIATED DIFFERENTIATION MARKER; 1.
DR PANTHER; PTHR17068; MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER; 1.
DR Pfam; PF01284; MARVEL; 2.
DR PROSITE; PS51225; MARVEL; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..163
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 168..319
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
SQ SEQUENCE 322 AA; 35293 MW; 75AE4085421958D5 CRC64;
MPVTVTRTTI TTTTTSSSGL GSPTIVGSPR ALTQPLGLLR LLQLVSTCVA FSLVASVGAW
TGPMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN FPITFACYAA LFCLSASIIY
PTTYVQFLSH GRSRDHAIAA TFFSCIACVA YATEVAWTRA RPGEITGYMA TVPGLLKVLE
TFVACIIFAF ISDTYLYQHQ PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL
SGLALLSVLL YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCGW DRRLAVAILT
AINLLAYVAD LVHSAHLVFV KV
//
