ID A0A2J8UWX1_PONAB Unreviewed; 388 AA.
AC A0A2J8UWX1; H2PG11;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ATP6AP1L {ECO:0008006|Google:ProtNLM};
GN Name=ATP6AP1L {ECO:0000313|Ensembl:ENSPPYP00000017449.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017449.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000017449.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000017449.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the vacuolar ATPase subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00009037}.
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DR AlphaFoldDB; A0A2J8UWX1; -.
DR STRING; 9601.ENSPPYP00000017449; -.
DR Ensembl; ENSPPYT00000018156.3; ENSPPYP00000017449.3; ENSPPYG00000015609.3.
DR GeneTree; ENSGT00940000158156; -.
DR InParanoid; A0A2J8UWX1; -.
DR OMA; SRKGQWE; -.
DR OrthoDB; 2878970at2759; -.
DR TreeFam; TF325819; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.160.110; -; 1.
DR InterPro; IPR008388; Ac45_acc_su.
DR InterPro; IPR046756; VAS1/VOA1_TM.
DR InterPro; IPR046755; VAS1_LD.
DR PANTHER; PTHR12471:SF3; V-TYPE PROTON ATPASE SUBUNIT S1-LIKE PROTEIN; 1.
DR PANTHER; PTHR12471; VACUOLAR ATP SYNTHASE SUBUNIT S1; 1.
DR Pfam; PF20520; Ac45-VOA1_TM; 1.
DR Pfam; PF05827; VAS1_LD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 52..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..292
FT /note="V-type proton ATPase subunit S1 luminal"
FT /evidence="ECO:0000259|Pfam:PF05827"
FT DOMAIN 308..342
FT /note="V-type proton ATPase subunit S1/VOA1 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF20520"
SQ SEQUENCE 388 AA; 44165 MW; 130233FD227D2B99 CRC64;
MGYILRKLPC YWLNMLSVTW HEKYCLCSVC IYELTDVLAL KKLILFLMGK KILFSFSLIF
LCIGFSLTLD HIFARKNVSS PTSSNKEVVM KNDRNNGDMK PVQNFTTIPI TQALNYNLSK
EGHLEKEPWN AFNHHGPVNV SIDGIPCILF WAKRIMIKFK NQTWLDLTYE AFGQKVTVDP
DNSNCTEESA RLSLKLGDAG NPRSLAIRFI LTNYNKLSIQ SWFSLRRVEI ISNNSIQAVF
NPTGLYAPSG YSYRCQRVGS LQRDQALLLP SDMDDGSSLW EVAFIDFQIQ GFAIKGGRFT
KAQDCTSSFS PALLIGLAMS LVLLLVLACA LHMLIYLRYL DRQYDLIVSP AHFLQLKARD
TAEEKELLRS QGAECYELRS QQISKIYV
//
