ID A0A2K0W3E4_GIBNY Unreviewed; 1248 AA.
AC A0A2K0W3E4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=FNYG_09823 {ECO:0000313|EMBL:PNP76807.1};
OS Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=42673 {ECO:0000313|EMBL:PNP76807.1, ECO:0000313|Proteomes:UP000236664};
RN [1] {ECO:0000313|EMBL:PNP76807.1, ECO:0000313|Proteomes:UP000236664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS10214 {ECO:0000313|EMBL:PNP76807.1,
RC ECO:0000313|Proteomes:UP000236664};
RA Gardiner D.M., Obanor F., Kazan K.;
RT "Genome of Fusarium nygamai isolate CS10214.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNP76807.1}.
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DR EMBL; MTQA01000136; PNP76807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K0W3E4; -.
DR STRING; 42673.A0A2K0W3E4; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000236664; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF49; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000236664}.
FT DOMAIN 48..467
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1248 AA; 136120 MW; B4754B4C9C8557EB CRC64;
MMSTKVTKDQ TNGHTNGYTD HYSNGGSAAN GQASELFGSD PIDQKDVHEP IAIIGMGMRL
PGGVHNAEAY WDLLVNGKDG RCQVPKDRYN IDTWYGPGRV THVGTKYGHF LEELNLANID
PNFWSFTKQE AELLDPQQRL FLEVVYEAFE NSGTTKWRGK DVGVYVGALG DDWGEMEMQD
GQDLNPTRTY VYGDYIIANR ASYEFDLKGP SMVVRTACSS SMIALHLACQ DILSGDCADG
AIVGGINLII TPRTTVTLTE QGVLSEDGRC KTFDADADGY ARGEGVSAIY IKKLSDAVRD
RDPIRAVIRS TCAAADGKTA GFTMPNPESH EKLMRRGHRL AGISDFSKTA MVECHGTGTA
VGDPREVSAV ANVWGDHGIY IGSVKPNIGH GEGASGLSSI MKMTLALENK TIPPNINFKT
PNPKIPWEEA KLKVPLKATA WPTDKLERVA VNSFGIGGAN AHVILESAAS FGFGRTPESK
SQGSGDGNLG WHLLTFSAKH PKALEMSAQR HEEYLTTHPD SLSNMAYILN TKRMVHSHRA
FCVTDGLDSF ERSKIIKPAL RSKCDLIFVF TGQGAQWAGM GLELLRSDGI FKDTVDYLDT
ELLRLSDGLN WNMRDEILAT ENTSCLSEAE ISQPCCTAIQ IALVELLRSW VISPDAVVGH
SSGAIAAAYA CGAISAQDAI RVAYYRGNST IALKSLRKGG MAAIGLGRED VEQYLQPGVT
IGCENSPASV TLTGDADVLE RVMGTIRTAD PSVLVRPLRV ECAYHSEHMK IVAQDYAARL
GTVNASQPQV PFYSSVIRGV NSDLSTSYWT ENLVSPVFFK GAIQTALQSH DNLTFVEIGP
HSALAGPIRQ TIQSEIKSNA GYIPTLVRKK DAHLSILSTA GNLWLAGTPD LDLSAVNLHG
RPEGGELLTD LPTYSWHYDG EYWLENRLSR DWRFRKFDHH ELLGARVLES ADAGPAWRCK
LRVQDAPWLS DHDILGDIIF PGAAYLCMAG EAIKQLRPGS HDYSLRRVTL ASALVLHGDP
VELVTTLTPV RLTNAADSDW YSFTISSFTA TTNTWTKHVS GQVRSGRTFV PDTPKIEPLP
RKVPTSVMYN VWRRFGMNYG GRFRGLDDIS AHTTEKRAVG TIYQKCLPEE SELYSVHPAS
IDAAFYLSNV CLCHGLGRNF RTPSVPKYIE EMYVGRPEGP IRVVGDAANK GRGGSMSNLV
GVSNGKVVLS WKGLELSPLS DGSDVVDDDP HAAAVLEWKT DADFIDAT
//
