ID   A0A2K0WHH4_GIBNY        Unreviewed;       860 AA.
AC   A0A2K0WHH4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Ergothioneine biosynthesis protein 1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=FNYG_04754 {ECO:0000313|EMBL:PNP81728.1};
OS   Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=42673 {ECO:0000313|EMBL:PNP81728.1, ECO:0000313|Proteomes:UP000236664};
RN   [1] {ECO:0000313|EMBL:PNP81728.1, ECO:0000313|Proteomes:UP000236664}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CS10214 {ECO:0000313|EMBL:PNP81728.1,
RC   ECO:0000313|Proteomes:UP000236664};
RA   Gardiner D.M., Obanor F., Kazan K.;
RT   "Genome of Fusarium nygamai isolate CS10214.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00037882}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNP81728.1}.
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DR   EMBL; MTQA01000064; PNP81728.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K0WHH4; -.
DR   STRING; 42673.A0A2K0WHH4; -.
DR   OrthoDB; 1416at2759; -.
DR   Proteomes; UP000236664; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR024775; DinB-like.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   NCBIfam; TIGR03439; methyl_EasF; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF12867; DinB_2; 1.
DR   Pfam; PF03781; FGE-sulfatase; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236664};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          53..344
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   DOMAIN          370..505
FT                   /note="DinB-like"
FT                   /evidence="ECO:0000259|Pfam:PF12867"
FT   DOMAIN          565..858
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  96914 MW;  1895CF0ED82CD921 CRC64;
     MPSITTASAA PQRVKPTTAK PSPALPSIID IRGEHVEINL KDQITSMFNP DEGPRKLPTL
     LLYNEKGLQI FEDITYLDEY YLTNYEIEIL KKSSAEIASQ IPEGSMVIEL GSGNLRKVCL
     LLQAFEELKK PIQYFALDLS LKELERTLAQ VPDFKYVSCH GLHGTYDDGR EWLKHPSLTS
     RSKCIIHLGS SIGNFTRDGA ADFLGGFAEV LTPSDSMIVA VDSCSNPAQV YHAYNDSKGV
     THQFILNGLQ NANEILGEEA FNTDEWRVIG EYVYDVEGGR HQAFLSPTRP TDALGSRVLP
     HERIEIEQSL KYSEAEKDRL WKLAGLTEMG QWSRGDEYGL HFLQKSSMPF SLIPSLYAAE
     PLPTVRDWKA LWKAWDVVTK DMMPDEELQE KPIKLRNACI FYLGHIPTFL DIQLTKTTGS
     GPTEPAAYYS IFERGIDPDV DNPEHCHTHS EIPDEWPSVQ EIMTYQDRVR SRLQNLYKNG
     QDKIPRDIGR AIWVGFEHEL MHIETLLYMM LQSDRTLPPP HTAQPDFAKL AQQAHDARVP
     NQWFYVPEQT ITLGMDDPED GTDNSRHFGW DNEKPARQTK VHAFQAQGRA ITNEEYTQYL
     YNSKIEHIPA SWSSITNAHT NGATNGSHTN GNSNGYSNGN GHHASQVPDS FIQDKFVRTV
     YGLVPLKYAL DWPVFASYDE LAGCAAWMGG RIPTFEEAKS IYAHVNKQKR AEAERTLSKT
     VPAVNGHLVN DGVEETPPSN SSALVKDGSS ELFFDLTEAN VGFRHWHPMP VTSQGNKLAG
     QSEMGGVWEW TSSPLERHEG FEPMSLYPLY TTDFFDGKHN VVLGGSWATH PRIAGRASFV
     NWYQRNYPYA WVGARLVRDV
//