ID   A0A2K0WTN0_GIBNY        Unreviewed;       572 AA.
AC   A0A2K0WTN0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN   ORFNames=FNYG_00652 {ECO:0000313|EMBL:PNP85596.1};
OS   Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=42673 {ECO:0000313|EMBL:PNP85596.1, ECO:0000313|Proteomes:UP000236664};
RN   [1] {ECO:0000313|EMBL:PNP85596.1, ECO:0000313|Proteomes:UP000236664}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CS10214 {ECO:0000313|EMBL:PNP85596.1,
RC   ECO:0000313|Proteomes:UP000236664};
RA   Gardiner D.M., Obanor F., Kazan K.;
RT   "Genome of Fusarium nygamai isolate CS10214.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC         ChEBI:CHEBI:57924; EC=1.14.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000426};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC         ChEBI:CHEBI:58315; EC=1.14.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001038};
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC       {ECO:0000256|ARBA:ARBA00009928}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNP85596.1}.
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DR   EMBL; MTQA01000018; PNP85596.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K0WTN0; -.
DR   STRING; 42673.A0A2K0WTN0; -.
DR   OrthoDB; 1908494at2759; -.
DR   Proteomes; UP000236664; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF76; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   3: Inferred from homology;
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236664};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..572
FT                   /note="tyrosinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014438779"
FT   DOMAIN          108..125
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          294..305
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   572 AA;  62761 MW;  44CEE5F9A1477B75 CRC64;
     MLGKFLVAAL AVIGGVSPVE AQQQNIFVTG VPVTGGAAVP ARKNINDMQK AGGPAWDLYM
     RAVRSMYDAK ETDWKSYFQV GGIHGKPFIQ WNGGGGRSGN GWPGYCPHGE SIFLTWHRPY
     VLLYEQILVE HAKRLANLYP SKYRKQYVDA ANNLRAAYWD WALDGIPAIL TQQNVAVKVP
     NGSGLKTINM KNPLYTYNFP KDALNNKYGS WDDEHRVRIY HCPAPDSFPS SANKLLRQRP
     YKQWVYDVMT RPTTFNQFAS TGANGASLEQ IHNAIHWDAS CAGQFLATEF SGFDPIFWLH
     HANVDRLWAY WQAMHPSQST FTGSYSGGAR YSTPQGTRIT PSSPLNPFYK SRGNFHTSDS
     VKSIKGFGYT YAGLEYWRMS ASQLSSSART TINRLYGSGS SRRRDVEERG LIEERAGANT
     TRYFANVQLD VTEVERPAQV NVYVSGKLVG GLVVMRQPAE GIIHGSFSAD QAADAPQLLA
     ACSPTKVADA VTSGLQVEIV KLDGSKIDIS TVPSLKLSLD DVAYTPPAAE DDLPVYGTPR
     TQPAKAVALT NAKALKAVAA CANKLPSFNP PV
//