ID A0A2K0X2X8_9BIFI Unreviewed; 1588 AA.
AC A0A2K0X2X8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BFS08_06060 {ECO:0000313|EMBL:PNP88881.1};
OS Gardnerella sp. KA00735.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Gardnerella.
OX NCBI_TaxID=1973156 {ECO:0000313|EMBL:PNP88881.1, ECO:0000313|Proteomes:UP000236541};
RN [1] {ECO:0000313|Proteomes:UP000236541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA00735 {ECO:0000313|Proteomes:UP000236541};
RA Bumgarner R.E., Fredricks D.N., Srinivasan S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNP88881.1}.
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DR EMBL; NBMV01000002; PNP88881.1; -; Genomic_DNA.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000236541; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 27..443
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 444..834
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1171..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 48..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1588 AA; 175988 MW; 84ECC818A239F2A3 CRC64;
MMSEQVLNEK LQENVQENVQ VKSEKIVFSD EQSRVINSPS DSNILVVAGA GSGKTFTMTQ
RVIALINQGV APESILGLTF TNKAASELLS RVSAAVSKSS SNSFLKPEVM TYDSFFQSIV
RKYGILIGFS QNVMPLSNAG AYELIKSVVG DYLDKNSASL DLYSSDSVIS LYNFNSLCKD
VLSLYSNIAC SMIGVDSQGN VCDSVVQAVD KIRAWNNDFL QFMNKIVENK TLEENSSSDI
AIPKYSKAKS KSVEEKNELF KKACNKFEKY WENACVEECM NLISAAKKRN ILLDLVLDFD
KAKHKANMAQ FSDFTIAAYR LVTHFPSIAI QYREQYKQVL LDEYQDTSTT QSMLINRLFN
NNTDICKDGI VNKNETYITA VGDPFQAIYG FRGASSGAFI AFKNSFKSKI DKNLSSDANT
LNPVNDLESN LSECSLTTTR RNAHLILKLA NDLTKPMRDS ELQNKSSVEH REVDVEVLKP
MDNATLGTVA AVVMPTKYQE IEAVVRFAKL FSDPTLTPFP ADENRNPLKP RVAILFRSKL
SMPLYADALR SAGLKVSVVG CSSAKEDPCV KDVLALLNVV NDHSCSSSLM RLLATPRFSL
SAKDLKTLAN IANDANIKYK YDIYVQAGLL PCGLSGAEMI KAVKNQRANS SNTSSQNSID
NGVFLADIFM QNIPENPFKY KNKSEIKYNS SSEKSSDSNN TVCELYNKLS KHGYAVVRRV
SDMLQTVTRA CNNSLNDVMR VAVEALNVDI DSAVASCIKD DCINRENVLH AMHSTLDSLN
SITDTYIQEM GEWQKPSLKG LMSWIESSDD FDSADSIEDD NAQVVMMTVH QSKGLQWPAV
AVVGLNAKKF PSSQGDNLSF ALDSDDDVEY IDNLKNSGAD LIFDSSLLAS SAHVPIEYAS
SVPVPLRVDS GNLPHFPHDA SLSSGMHPLE SLKKYDSVEK IYDEIKTNRR VALRSLAKYV
YESDAIESGV DLDQFLSDDT KEIYRNNCDI LTQSEERGNQ LHMEERHLLY VAMTRAQFAT
MLTCARTTQM ASDDAKSDMK LSVFMKEALN SLYNMESDCE NLKSDTFNDK TSEYKKIILN
KSADVKSDDV KSDDMQSDDV KSADVEDEVC DESCSNFGIA VGEYASKLAD VLQERTNQPA
SIGNIVLPWP ITLSKDLEDT LNESVRLMKS NIDDSSSDSS SDSSSDSSSD SSSDSSSDSS
LCSSSDLNSS SDSSCSNSCN LENLSLTNRV KMFISDSDFG LKNYNSNKDL AEYVRQKAED
SEKNNSKALS ITTLQRSAKI SNSSNKSNSR DIDRRMLAYI RPIPSVSTIN SDMGTKFHEW
AESFVNAGNL EMSNFAKNES SVSDESSKSY DFSSSSEFDS STYNSSAILD SYDDFSNSMI
SRIDVQLSIF AHLVSESKVC ALAERNNLTD SQQALANSLA DSLANKNIAL NNENNTNLVN
CDISSLKLDD REDLLNIWKT RLVKSRWAKR VSLAAELPIS YALESNGNNP RVLNGILDAV
FLGGLNPKDT SKRFTVVDWK TGKKPTVKKE IERKLVQLDW YRLMLSALTS AKLDEIDATL
YYVSEENEES REIHALLKTE QQIRSELS
//
