ID   A0A2K0X5V2_9BIFI        Unreviewed;       501 AA.
AC   A0A2K0X5V2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Ribonuclease D {ECO:0000313|EMBL:PNP89892.1};
GN   ORFNames=BFS08_02885 {ECO:0000313|EMBL:PNP89892.1};
OS   Gardnerella sp. KA00735.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Gardnerella.
OX   NCBI_TaxID=1973156 {ECO:0000313|EMBL:PNP89892.1, ECO:0000313|Proteomes:UP000236541};
RN   [1] {ECO:0000313|Proteomes:UP000236541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA00735 {ECO:0000313|Proteomes:UP000236541};
RA   Bumgarner R.E., Fredricks D.N., Srinivasan S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNP89892.1}.
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DR   EMBL; NBMV01000001; PNP89892.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K0X5V2; -.
DR   OrthoDB; 144122at2; -.
DR   Proteomes; UP000236541; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR041605; Exo_C.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR   PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF18305; DNA_pol_A_exoN; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
FT   DOMAIN          228..308
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          360..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  57517 MW;  D9B5A226BD821D23 CRC64;
     MFEEPKLLKE PREGVPEVID TLEAYKDYCS LLASGSGPLA ADAERASGFR YSHEDWLIQF
     KRKGAGIGLL DPIELTKLGA DWNEFNKAVG DVPWIIHDSM QDLPGFFDIG LRPRALFDTE
     IAAKLLGRKR FGLSSVTEYY LGLTLAKEHS AADWSYRPLP RDWRNYAALD VELLIELEEV
     MRAELKKQGK LSWAEEEFAH LLIAGAKKKA KHPRPWLRIS HISVLMHDKI GLMIAKELWQ
     KRDELARQYD IAPTLLLSDA AIIEASKRKP NNSRSFRSIR ILNERVRIHT GCEQDKMFER
     YAPIQRKIKP NVWKLVIEKA ISKAKSGIDA MSIDDDSSDC SSSNNFHRCL VNSSSNHADH
     SDTRFYGDSE NSKDSESSRD HIKNNENIKN VADCEHIEHK NISDFENSFE QDCQCAPKSM
     KYWREHHPNR FAILQKVKAV VMRIAEDTHT PMDVLIKPQI IRNLCWNDDI KNIDVRLFLI
     EQGARVWQVD LISESVTRVI I
//