ID A0A2K1IBE3_PHYPA Unreviewed; 571 AA.
AC A0A2K1IBE3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Hedgehog protein Hint domain-containing protein {ECO:0000259|Pfam:PF01079};
GN ORFNames=PHYPA_030070 {ECO:0000313|EMBL:PNR26589.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR26589.1};
RN [1] {ECO:0000313|EMBL:PNR26589.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c26_1130V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR26589.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c26_1130V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c26_1130V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; ABEU02000026; PNR26589.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1IBE3; -.
DR STRING; 3218.A0A2K1IBE3; -.
DR PaxDb; 3218-PP1S149_123V6-1; -.
DR EnsemblPlants; Pp3c26_1130V3.1; Pp3c26_1130V3.1; Pp3c26_1130.
DR Gramene; Pp3c26_1130V3.1; Pp3c26_1130V3.1; Pp3c26_1130.
DR InParanoid; A0A2K1IBE3; -.
DR Proteomes; UP000006727; Chromosome 26.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016540; P:protein autoprocessing; IEA:InterPro.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR InterPro; IPR001767; Hedgehog_Hint.
DR InterPro; IPR036844; Hint_dom_sf.
DR PANTHER; PTHR11889; HEDGEHOG; 1.
DR PANTHER; PTHR11889:SF31; PROTEIN HEDGEHOG; 1.
DR Pfam; PF01079; Hint; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..571
FT /note="Hedgehog protein Hint domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033310444"
FT TRANSMEM 541..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 292..482
FT /note="Hedgehog protein Hint"
FT /evidence="ECO:0000259|Pfam:PF01079"
SQ SEQUENCE 571 AA; 59676 MW; 307EB2250DC3082D CRC64;
MIRMLLPLAF LLVLTHQAGV LVGAQLAISV TTFGPPHADG TPNTFIGTGS QIASSLLGST
TKALMWGVVS SSDVNAVCDQ IVSTGALTFS ATLTATTGET ETLQQTITHV GGCRAAADGS
GTQAVMVDNN GRQSAVVCPN NAGSTGCGIY LTGPDVTALY NQGARRRLLA RNLLARKLLQ
GDNCQTGAAK GALTGAITSM EACIPFLGPL YPFCMAGVIG VATAGGAAVG CAEANGCFPG
TELHPSIAQL LARWTFSTGV MDPDARLDQP ALTAYVGIRA FRTPSLTLRA LAGDATVLLA
GGEVKPMTSL ALGDKVAVRR HDGGLDYEDI YAFGHKDALA AANYVQLSLK PVGANMSDPA
LESTKLELTP LHFTVILSGT SWSPLVRSST LANLPWIAII MKFFIPCLAI ASEKPWSEIT
YKRAQDVRVG DMMWAQASTH AAELSPYLVT DISTVEKQGL YNPFTLGGTI IVNGVAASAH
SEWFLDGAFD ALGLTHWIPS AYQMVLAPMR LAYYGLGKQA YLDLYLRLDA LVDVAQFGTK
FGGPVVTAAA GLGSSIIAAL LIFKSSRPKT A
//
