ID A0A2K1IP97_PHYPA Unreviewed; 4680 AA.
AC A0A2K1IP97;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Peroxin/Ferlin domain-containing protein {ECO:0000259|SMART:SM00693, ECO:0000259|SMART:SM00694};
GN ORFNames=PHYPA_027394 {ECO:0000313|EMBL:PNR31078.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR31078.1};
RN [1] {ECO:0000313|EMBL:PNR31078.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c22_21110V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR31078.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c22_21110V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c22_21110V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; ABEU02000022; PNR31078.1; -; Genomic_DNA.
DR STRING; 3218.A0A2K1IP97; -.
DR PaxDb; 3218-PP1S225_55V6-1; -.
DR EnsemblPlants; Pp3c22_21110V3.1; Pp3c22_21110V3.1; Pp3c22_21110.
DR EnsemblPlants; Pp3c22_21110V3.2; Pp3c22_21110V3.2; Pp3c22_21110.
DR Gramene; Pp3c22_21110V3.1; Pp3c22_21110V3.1; Pp3c22_21110.
DR Gramene; Pp3c22_21110V3.2; Pp3c22_21110V3.2; Pp3c22_21110.
DR InParanoid; A0A2K1IP97; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000006727; Chromosome 22.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR InterPro; IPR009291; Vps62.
DR PANTHER; PTHR16166:SF137; PLECKSTRIN HOMOLOGY (PH) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF06398; Pex24p; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR Pfam; PF06101; Vps62; 3.
DR SMART; SM00694; DysFC; 1.
DR SMART; SM00693; DysFN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3180..3241
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 3250..3288
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT REGION 96..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1765..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2061..2096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2813..2844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3017..3053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3070..3090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3871..3900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4427..4497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2079..2096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2818..2844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3023..3038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4461..4479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4680 AA; 521076 MW; 98BB38259F0DA580 CRC64;
MLEEQLAFYL DRYLGEYVKG LSKEALKVSV WNGDVELTNM QLKPEALNAL KLPIKVKAGF
LGSVKLKVPW SRLGQEPVVV ELDRIFILAE PATNVEGGDA DSVQEAKNRR VRGEEDKLVT
SRTENSQKSE EANNSSWLGS LITTVIGNLK LSITNIHIRY EDEESNAGHP FAAGLTLAKL
AAVTVDEDGN ETFVTGGALD RVQKAGELNR LSFYFDTDTK PWPKEKSWED LAPKDWSQVF
LPGIKEEPSA YKGGKPPWIK DHTYVLEPVG GIARYFKLGQ KDTRSPDKPA QKALAILDDV
TISLNEKQYR DALKLAENIS MFSKRVQYAH YRPNRSIKED RKAWWKYLCT VVSEDQKKAS
GRLSWNQILS YSRMRKEYVS KYIAALKANP KATSINDNKE IKDLDRQLDS DIIVQWRMLA
HTYVDEEVKK GEERRQAQRS WWSFGWGGSG GGGSDASSKE FSDDDWKRVN QIIGYEEGKP
SPMVPSEGQP NMLHTLVEIQ MRHNGTKLIS SNGEIILALT AEGLGCGVKL YPETQIFNVG
LDSYKISTPE GLLGESAHDE KSLYGTFKLN PWDTELDWSL EAKAAPCYVT VRMQSIRRIT
QFFSSKEAVS RDVALQTAAA LQSTVNEVSK NAQQQLNDAL KNKPKFLLDL DIAAPKVTIP
TDFYPDGQHQ CKMLLDLGYL SIKTLPTDGS IDDSSEENQL YMRFRIGLKD ISAFLVDGDF
DWRKQYIVNS ATGKLRAVND NSSRLPERSE SSENSENKGT IDFEGKEDGA SNNVEEVTTG
SNDSQSNESF RKVGSDDGDL FFLPMLEKTG MIVALEQICV PHPKYPTTRV AIRVQSVGFQ
FSPARYHRIM QVVEVFSGGP DVDATQSAFR PWDSPDFDGK MMVLSWKGVG HREAKWEDRY
GALAGPFLYL LESDTSLSYK TYHSLLAKKV FNVPKESLGG LENVIAICDA GQLENKVTES
AGALLLRFED ENSRNTWQGR FAGAIYRASS PGAVTGLQSG KGESNDSVGD GSESEDVDHV
ERAEQETIFL TGVLNELKIV ISNSRDIDYT SPKLLLVPEK PLLELRAIGT KVQFVMRKND
MLVGAVLQAL EIEDKFHGHV SHSCRFLARS YIKQERDLKE KDDNQKVKSS SSHHSDQNTL
ENRKLQSIGS NGGKKKLANS SGNNSRKSGH SRSKHSHHGI SGDERFFDAN DESGYESSSS
NFSSHKLQSS SSDAASKFYD VEDGEDDHGE PPSFKREVGL LPGSASPQPG KDGQDVTEKE
ELQSFVKAQI IMTSPDSPTY ASIDKEVRLS LSALTFYCNR PTVIAALDLV TAITADVQPK
RDDESPPQVA DANEGSQKST EKDAKNSPDA SGNVGKVGKD EDAVDGGGDK IEGDDKENPQ
ASSADNDGVV TTINPKVVED VDELGNPKIA PKRKDSVVKG LLGKGKDRVV FLLVLDMELA
EIVLNNEDGS QLSTLSQDNF HTDVKIYPAS WGVKVTLGNL RISDDNVKDN HYRDIPYQYI
CDMRDPGGSS FIELEFESFN EDDLDYEGYE FSVAGKLSEV RLVYLNRFIQ EITAYFMGLV
PPSSDYVMKL KDHASDYEKL FSQSEIQGQP SVKLDLSLSK PIIIMPRGTY STDFMELDIL
HINIRSSSEW FGGRKEQLEA IRLETITLDI EDVSLTVGLG GEVGSEIFDR ARGFGLVVRR
SLRDLWHKVP VIEATVKVEE LRASLSDKEY QVITECVTQN MAETPDLPPT LYDKTPSAQE
KLMAEDEAQK LDREGASSRD IVAEEPQAAN DQVQEGNGSS SEKPYTTIKV GVGIDLVELR
LFVGGTRDAS LATVQIIGVW ASYKSNNVGA SVVMASLERL SLKDEREGTD PEMQYMIGHA
DDKAPNTLEG DPGLAKRNRK EKKANDTAVG TSQSPRGWGS GLTMLVVDAK LSPTQQQVSL
RIQRPRLVVA FDFLLAVGEF FVPSMHETLA EKGDENPLDM KNGMFLNDHI YKQTTKEIRI
SPKRPLVADH EGVHEYVYDG QGNKLRLLNR HGEDLSMFSP EAIIFVGDGK RLRFRNVIIQ
NGNYLDSSLY LGSNSSYSAS KEDGVYIEGP PEDSDASSTV SSHVEDKKDT EKKADDKPPV
EIVFDLQAIG PDLTLYDSIG RKAETLVLPE RHLRASMNVF ARFSMKGDDM ELAANLNGLT
VESTSGVSVL EPFDACLSYS KVEGKQNIHV SMTEIYMNFS FSILQLILRL QDDVMSIMRI
TSEQVTIECS EFEKIWGDDD SEIAAGGSHL AFWRPRPPPG FAVLGDCVTP LDEPPSKGVL
TINMALARGK RPTGFKCVWT SMGLASDDSV KSRVDGRSSH LSERSIKQEL DDAAISISDD
EDTLKKGCCV WLPIPPEGYV ALGCVVWKGQ EQPPPSATIC VLNALISPCS MRDCINIKGH
RRSADVDSHN KWAFWRADNS IGTFFLENDP KEFIPPQAYD LRLAISKYGL FTVKETVPSS
DHPQTRLSRT LMPIDEEGAC TTGLLTAVVS SGRIYENVGR FRLVWWNKGN GSKDGISIWR
PIVPSGCAML GDIVVEGYEP PGTGLVLRDT DEGGLISKPE RFQELAHISK QKHFDGVYFW
IPVPPPGYSV IGCIAGKNSR PDEDVMQSIR CVRNDLVSSA NFAESSLWTT RSLKPGQQQL
SIWPVENEAK TFFVKPGSYG RPPTQSALGL ANLGRQSQPD NLSVALEVKS ISATFYDDFG
GFMAPLLDVS ITGVQASLHG RMEAFSTVLN FSLTTTTYNS KFDVWEPLVE PCVAIVRYEY
DSDPQDKVRP TVSRVRINTE SDFNVNISVA NANMLLEAYS SWMKLNKLEE SNKKQEFQDK
SASSNNLSRR LSKLSTDTSV DNESNKNSFI MAHNEIGEKV WLRTVEGSGK VQVAPLLSNG
TVTIKLPVTR CFNNSIHHDT VQGRSAKFLA IRIGDAVLPA DHGVGGREYM AALRIVPINA
TSNSKQPQFQ SARTRCVNPC KDDNTDQAHV FWEELFVFEV RSGEANRAEI VVTDLAIGSP
VGYCSFNITD KGMDEWREDK SDSATSSSLA LRSVTLQPPK RKQNEDKEPL DEGCQNGFIN
LAAQVFTANG EEADDEDSDD VESQQNESSQ KFGAIEVSVT KNGPWSPVRL NYGLGPAPWH
LGRDYLASEM VVHDGVKHLF VRTLVTVVNE TEYQLEARLC PDFLLGSEKD GNELDVNGSE
NAVEEEVFEN QRKQPGKAWS HPTLPTDPGH FGTRDLSGSS KEFPQLPLPD GWVWMTDWQV
DKTEVVDYDG WAYSNDFHAL RDWPPTSTCD KNTSFVRRRR WVRSRQRKDS SKNLLISLGV
LEPHSSVACP IETLRTGGPD YVVQVKPRIG SVSSGVVRSW SSVVSHRGKL EQGRVKQPSK
ELRIRELQNT EVLLSCAVKE RDSNSNDNDV WLCLECKATE VGKSSQLVPI KDWRLTISAP
LELMNFLPVA CKFTVSEKAN GKEFLEIQSE SVEPGGSKAI ILADLRKALY LKWVPQSGWQ
PQGDDCLISQ PGKDPAKEVV VTNGVRDLAI HMQYCHGNND ISARVIQFYV PCWLDSTGCP
PMKCKLVGAA HLGRKKFKSD KSRVSKKHIQ EIDEEDMHQF PRMLSNYDSK VMGLAVALSG
SESTAFGPVS PLQPLEDPIG NVDLRVADNQ NLQFRFLVTT TLHPYGFAQT QVVRLRPYTL
FTNRLGRPLE LRQAGTDQSV TLHPWDWRTT FGFPAIQDSL QLQIRLEGSE WSFPFSVDDE
EIIDVIVCHI DGRRQSVRLD VHGHVDGSRF HGIFQLGSSR GPYRVENRTH KETIKFRQKG
LHENAWRSVR PHSSAIFAWE NLQGEKLLEV VQVRGDVPRS AEIDINKMGD HPPLSGDRSG
SFNICVRVLD APEAKIVRFF NSEVEIQDKD HAQGDEIEQS VPSQGATEPM QDEHETRPEA
PSQMEIVLRV HKFGLSVVDQ YPRELIFFVM EKVDVIYAMG LGDNVSRFTV TVGYMQVDNQ
LPLTPMPVLL APELQEGEDF VVKAIASMKA ETNEADKVYP YLSLKVTENA WRICVHEALI
WAFLEMYNNL HLDRLSSDSP VVQVDPEIRI EILDVSEVRL KLSVEASPDQ RPEGKLGIWG
PAVTTLGNIS KMPITFRPVF RENRRMRNSQ VQAQVLNRVK RDLVHQPLQL LTGVNVLGMT
SSTFGTMSRG AASLSRDDEF MRVRTNQENS RKIEGVKDGM VQGTTSLARG VGYGVKGIVS
KPVDGVRDGG APGCIQGVVK ALIGVVAQPL SGCLDFMSLS VSGIGTSCSN CFERFEHDRK
FERYRLPRAI KGDGVLTPYD SHAAHGQAIL RLAQSSRAIG SMDVFKTAGV FAFSDFYQEH
FYLPKDYILM LTNRRVSMLL SPSSHERDPR KELTDPCTIK WEIEWSNLLS MEESSESSEL
GITQVLLHLK HSSKDFTQVI SCYPPNDSEI PQATKIYRSV HQQWRSFCPA PQDPSKAKKP
RRLGRRPKAG SVWDNSKRSK NTQENSGRSH PEHSDASESS GQRWEVQGAP KTLGDDEFRC
ETSLGNPIWS FNKNKGSCLG SDCVTATDSI SFWRPDPPPE YISLGDVAFV GDYPDNQTVI
TYRYDDDKFE RPLDFVLVWR NWRDGSGSPI SIWMPKAPNG YVSLGCVVCA DFEKPDLDVV
WCVHSDMTEE TTLEDNPIWK APSEAPWHCF VYPVISEVKT FVALREEKSE NTPKPRKVIL
//
