ID A0A2K1J115_PHYPA Unreviewed; 2004 AA.
AC A0A2K1J115;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=PHYPA_023114 {ECO:0000313|EMBL:PNR35215.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR35215.1};
RN [1] {ECO:0000313|EMBL:PNR35215.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c18_14120V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR35215.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c18_14120V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c18_14120V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; ABEU02000018; PNR35215.1; -; Genomic_DNA.
DR STRING; 3218.A0A2K1J115; -.
DR PaxDb; 3218-PP1S3_417V6-1; -.
DR EnsemblPlants; Pp3c18_14120V3.1; Pp3c18_14120V3.1; Pp3c18_14120.
DR EnsemblPlants; Pp3c18_14120V3.2; Pp3c18_14120V3.2; Pp3c18_14120.
DR EnsemblPlants; Pp3c18_14120V3.5; Pp3c18_14120V3.5; Pp3c18_14120.
DR Gramene; Pp3c18_14120V3.1; Pp3c18_14120V3.1; Pp3c18_14120.
DR Gramene; Pp3c18_14120V3.2; Pp3c18_14120V3.2; Pp3c18_14120.
DR Gramene; Pp3c18_14120V3.5; Pp3c18_14120V3.5; Pp3c18_14120.
DR InParanoid; A0A2K1J115; -.
DR Proteomes; UP000006727; Chromosome 18.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0043504; P:mitochondrial DNA repair; IBA:GO_Central.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF154; DNA_MISMATCH_REPAIR_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727}.
FT DOMAIN 1632..1648
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 725..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2004 AA; 222110 MW; D0718E6A34B7896A CRC64;
MSQRWPLLHR RASSLDSMTA FRHTGLRFGA GKHLGKVGRN SMAGEVETTL RGSGTSTLVL
STMPCCLERL APVPFAGSGR KLGFRGVSPS YCDGLSLGLC SLSRGYQRYH KVGGKSSRLD
FHAIVNKVER TTKSALGSRF MVNARDLHVK HLRPFYFHGW PSLVDCSFFM REIDSRRLVR
IPNLGSLTEC VASLHDGASV DEDVCSELAL TSNLTEGVVW EEITTSTRSL NDAERASESP
SVFGASCEGF KEDSSMEGPH EIPIESQVDP TIIVFDIETT GFLKPGSKIV ELACRDIAGG
DCSTLETLVN PYQPVPIAST AVHKITSEMV NRDDIPSWTE VMTAFVDFVE SRRIGNSDVI
LVAHNGRRFD VPFIMKECYE CSMEIPSHWY FIDTIDLAKA MLKKRFGKTK LYNLQFLYYD
CYKLPRLEDA HRAGVDVDML ASVFGKLLME LEMPVSELLD QAFKASHIEL KPDLLLRENN
DRYTSLSKEV DETLLEQSMV DVIICERNVD PLPDSKVRTL LEPPDQGQDV EAICVSSEYV
ETEESWESTT GSITLNHSFM SKDSTAYSDG TRKIFLKKFE GFDTQTFTTA QLSGDENPRY
SEELSSGELD TRVEGVPIGD IQLDANRVHV AESLASATID EKLLGLEKGT PALENGITSS
WEDKYVLDDA QDNKTFEFED ALGLVLGNEE GLATSTPEPS SVNQVEEDAT VTSSLVSGDE
LPSKYFKSSR KSRTEECTIP TRSPSTCNDD PSFSNLHPAD VNPIDDLIGN ENLDGLEVAQ
QSKLSSPTVG DGGLQPLNIG GTLLSRKKGK RRGTGDVQTT ATRNIAHTVG DCEEQLSAAV
ATVINELYTC DIQPVRGPDS NDSSHGVQDE KQRRAKEQLH SSSVNLSFLS PMMRQYVETK
RQRPKFLLLS RVGDFYEAFF EDAERLAHAC NIRLSGVDGG KLLERKVPMA GVPYHKVDVY
LRTLLKKGIS VVKQDQVTAA DTKGGTIIDR QVTAVLTPGT LLDEAMLEDS CSNFLVSIFP
HADENGTWGL AYADISTGEF QATQGQGRSS LLHELQRLQP SEIIFPANVV CTVDKKTEIL
RPIGMPSEIC YSSRPTSEFF PAAAEKRLHA SFGEESLKAF GVPRSSHAIR AAGGLLGYIQ
ETQKLSNEEI PLQSPSFYST LDTMHMDDTV RKHLELLKTS RWDKAEGSLV WALDHSQTAM
GSRLLRRWLL WPLIDHELIC RRQDAVQVFF HNHEMRSEFR SKLAHVSDVE RIAARIAWKR
ADSRDLLTLA QSIKCLPSLA ELIEGASLNS YFVAASQIPT TAVQWANKVE NMIAEELGNG
LQSGKLVKEG VDPTLDVLRQ KVQENMIWLE MYEEQERLRI GIPSLEVGFN KNSGHFISIR
KNKLKEDCIP NDYQKLQSLK AEERFVTPEL LNCESSLLAA EAKVFEREEE LLRSLKEELV
SLLEPVREYS QTVAALDVLC TFAELAVNRD YCRPHMLEKG REITIIEGRH PVVELSLPDD
SRFVPNSVYL GFDVITEKIP ATERYGLGEK LDGAEAMEEL TVESEKWWPR ADLVLLTGPN
ASGKSCYLRQ LGLIQLIAQS GSFVPAKFAR LSIADGVYTR VGAVDDLAAG QSTFRIEMVE
SANILNRATA HSLVLLDEVG RGTSSQEGGV IARAIIEYLS QIVRARTIFS THYHDLHILD
QDYPNVANYH FQATELDNGE VIFDHAVMPG YAIKSHAIAI GRSAGLPDWV CSRATELLAL
EEGLCASSDS CREQSDLDVP QTYENEVYED RGNNESYDKN LAIGLDEVVK DANCSGEALA
SNKSLEYNEG RCIPNLKGLE EMESEDLDDD LDKTEGHMNG DATSHVSSKI PSSFDFPENI
EQSIAMDQGS SDFVSSINLE GNGDGASEST GQHLQVQVEV QDQSEAHAIQ EEKCYSREQL
DEVWGQVYIA LQNQPATQAL LKQKGSLVSV SLLLDEFQVC VSASSLFVRK FQQPEHFATL
ESAFALVLHQ PVHLRISART DGSP
//
