ID A0A2K1JD88_PHYPA Unreviewed; 1123 AA.
AC A0A2K1JD88;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
GN ORFNames=PHYPA_019773 {ECO:0000313|EMBL:PNR39495.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR39495.1};
RN [1] {ECO:0000313|EMBL:PNR39495.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c15_14980V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR39495.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c15_14980V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c15_14980V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- FUNCTION: Leucine-rich repeat protein that likely mediates protein
CC interactions, possibly in the context of signal transduction.
CC {ECO:0000256|ARBA:ARBA00037519}.
CC -!- SIMILARITY: Belongs to the SHOC2 family.
CC {ECO:0000256|ARBA:ARBA00023786}.
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DR EMBL; ABEU02000015; PNR39495.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1JD88; -.
DR PaxDb; 3218-PP1S104_63V6-1; -.
DR EnsemblPlants; Pp3c15_14980V3.1; Pp3c15_14980V3.1; Pp3c15_14980.
DR EnsemblPlants; Pp3c15_14980V3.2; Pp3c15_14980V3.2; Pp3c15_14980.
DR EnsemblPlants; Pp3c15_14980V3.3; Pp3c15_14980V3.3; Pp3c15_14980.
DR EnsemblPlants; Pp3c15_14980V3.4; Pp3c15_14980V3.4; Pp3c15_14980.
DR EnsemblPlants; Pp3c15_14980V3.5; Pp3c15_14980V3.5; Pp3c15_14980.
DR Gramene; Pp3c15_14980V3.1; Pp3c15_14980V3.1; Pp3c15_14980.
DR Gramene; Pp3c15_14980V3.2; Pp3c15_14980V3.2; Pp3c15_14980.
DR Gramene; Pp3c15_14980V3.3; Pp3c15_14980V3.3; Pp3c15_14980.
DR Gramene; Pp3c15_14980V3.4; Pp3c15_14980V3.4; Pp3c15_14980.
DR Gramene; Pp3c15_14980V3.5; Pp3c15_14980V3.5; Pp3c15_14980.
DR InParanoid; A0A2K1JD88; -.
DR OrthoDB; 1211301at2759; -.
DR Proteomes; UP000006727; Chromosome 15.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45752:SF199; LEUCINE-RICH REPEAT PROTEIN SOC-2 HOMOLOG; 1.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 346..599
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 564..591
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 125472 MW; B66750E455C8FE77 CRC64;
MGKQTEQSPP EAKNLLSNQK SPRSPKYGPK SVFKLDRFES PRGSLTKSND SPRLSVAFSS
SSANNISPNG AKQASTVSKQ LDFSSPGSVS SKNGTKTSPK CAAPRLVLDT VNSASLNSSR
RFSHNGPGDT ESVADFPCSS ITIDELRQIE QILQASSTRL EELYKKVSET LFKDHSAVFE
SLQWDILKET GYISWFELAL TLAGFLSSHC IEEEGLVDKK SKWALLKSKS DCIFEQLDEL
KTNLESDSDI YKLAAGTLVY CCSVVRHLEQ KSQKCGCFGP RSDVYFNEQI EKTTQELKGL
QDNLNFATLA AVGNRVSQPI ARSPRIVMRR PEQVPSIVGL EPHISHIAEY MKKNGVCLIG
IYGQSGIGKT TLLNEIVSKV EASEKRLFAY IELNEDVRRL QSSLLLQLGG GRKEFSNSAQ
GRNAILYQLQ KLKQQSKAVR IAIDNLYDVR LVGELFPHSL WKVLSNQSSV LITCSSLSIL
AKVDQLCRTA IPAYNYLPYK FPHMTAEHAK ALFISYAASE PVKSLSSMNG VFAKYGDLAE
NFLPLCEGLP IAVKVVGSYF ATPANRTEEN CSTIIKRMKQ AEEEMDTSED QMCAKLMVIY
EKLDLDQKEA FLDIAAFCRY WDWRTVERIV GKAQLDTLVD LGLVHAKLRD TDSFAGIAHL
TRYSEHPWRT DMVMMHDLLY TIACRRTQGN RVHSEDQAHL PDRLLMDSPG SELSQIQGLS
LISCKEALQG TMLEKMLNVR TIILHDVNIK GFCTKNLNQL QVFYWGKSQI ARDVRIPFQL
CKMRKLEMVI LRATEIDLGI KFPSQLRDLT ISGCNNMDEL PETILVLTSL LELHLISCNK
LQDLTIGFGS LKSLCRFRLE NCLSIRQLPK AIGQLTNLQE MDLSGCTNIT TLPSEIGNLL
GLQKLNLSRC KCLIRVPVEL GSLTKLTTFN LSQSGITTLP QEIGKLRNLE SLFLFGCSRL
EKLPKDIGKL SSLLQLHLGS CTSLKEIPRE IGKLESLQKL SLNSCTSLVR LPEEVFHIVT
LQALDLDHCK LLAHLSSEIR NLKSLQRLSL NCCTRLNRLP LEIASLPSLE VLNLVGCTGL
KPELPKDLRK MTKENSVKVH RDDDLVILEG PKNPSFKLYS MAY
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