ID A0A2K1KC96_PHYPA Unreviewed; 918 AA.
AC A0A2K1KC96;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Mechanosensitive ion channel protein {ECO:0000256|PIRNR:PIRNR017209};
GN ORFNames=PHYPA_010590 {ECO:0000313|EMBL:PNR51403.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR51403.1};
RN [1] {ECO:0000313|EMBL:PNR51403.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c7_19980V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR51403.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c7_19980V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c7_19980V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|PIRNR:PIRNR017209}.
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DR EMBL; ABEU02000007; PNR51403.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1KC96; -.
DR STRING; 3218.A0A2K1KC96; -.
DR PaxDb; 3218-PP1S2_432V6-1; -.
DR EnsemblPlants; Pp3c7_19980V3.1; Pp3c7_19980V3.1; Pp3c7_19980.
DR EnsemblPlants; Pp3c7_19980V3.2; Pp3c7_19980V3.2; Pp3c7_19980.
DR Gramene; Pp3c7_19980V3.1; Pp3c7_19980V3.1; Pp3c7_19980.
DR Gramene; Pp3c7_19980V3.2; Pp3c7_19980V3.2; Pp3c7_19980.
DR InParanoid; A0A2K1KC96; -.
DR OMA; DINIRNM; -.
DR OrthoDB; 11155at2759; -.
DR Proteomes; UP000006727; Chromosome 7.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0006820; P:monoatomic anion transport; IBA:GO_Central.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR PANTHER; PTHR31618:SF7; MECHANOSENSITIVE ION CHANNEL PROTEIN; 1.
DR PANTHER; PTHR31618; MECHANOSENSITIVE ION CHANNEL PROTEIN 5; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR PIRSF; PIRSF017209; Memb_At2g17000_prd; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR017209};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 312..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 740..797
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT REGION 96..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 103680 MW; 1271E6C98C898350 CRC64;
MEERLSPRVC FEESSGELEP EWVKRGVSWH ERTDHDQLEK ASLLGQESAL GNAPQKRWRA
KSLSMGHGKV MDSSASYWKK QPTDLAIEMD HVNADNRSSQ LKRSSLPHGS ETQINSQSGP
EMNKDDLDVS SNWQGFFQVD SSHTNSQKIP ALLSRLPYSG ENDTNIIENP AFAFDAVRTT
GDRFNRGEEL RSLRLRKSSS SSQHNSPRDD VVLSASTMST SPYNRAKSRF AEPRKPMDHF
TGSPRRSGVV RSGQRVSDPQ RSQHLRSGKL WSGQLKSQMM KSGMMPLGPL EEDEDPFNDL
DMPDRPKFQR KLTCGVCLEW IAFFVLLGAV ICSRVLPKAR NMALWGLLLW KWFLLALVIV
CGRLVSGWVV RSLVIVFEIN FLLRKRVLYF VYALRRGVRN CIWLASVLMA WNFMFDSRAQ
ALSAKLVYIT KVLQCILLAA ILFLVKVFLV KLLASSFHVG TYFERIRDSL FNQYVLEILS
GPPVLEMDRL KHEDEKLIEE VSLLKKAGAT TKGLEGLPGI GENTEARMSK NLGRSRTGIS
REVKPGSNIT IEHLHKLNRK NVSVFNMKRL INLVKHQGVT TFGQGLDGGV GKGVDTEIKS
EWQAKVVAKE IFDNVSSPGA PHIIEEDLLR FLSEQDTIRT LALFEGAMET GKITKKALKS
WVVNVYQERR ALALSLSDTK SAVSKLHRII DVILFVIVVV IWLLILDIAT TQLLLFVSSQ
LVLMVFIFGN TLKTVFEAIV FVFVHHPFDV GDRCLIDGTM YVVEEMNILT TVFLGDFNAK
VWYPNSVLAS KPITNYYRSP DMGDMFEFFI ATSTTAEKIG RLKEHIGRYI TGNPQHWKET
FVLNCLDCAP DTGKLKLVVG LSHTMNYHNI GEKVARKSQL ILEMKKGFEE IGIEYHLPPQ
DVHLKSIPGT TINFDRSL
//
