ID A0A2K1KPX4_PHYPA Unreviewed; 1884 AA.
AC A0A2K1KPX4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PNR55835.1, ECO:0000313|EnsemblPlants:Pp3c4_25310V3.1};
GN ORFNames=PHYPA_006732 {ECO:0000313|EMBL:PNR55835.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR55835.1};
RN [1] {ECO:0000313|EMBL:PNR55835.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c4_25310V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR55835.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c4_25310V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c4_25310V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; ABEU02000004; PNR55835.1; -; Genomic_DNA.
DR STRING; 3218.A0A2K1KPX4; -.
DR PaxDb; 3218-PP1S60_296V6-1; -.
DR EnsemblPlants; Pp3c4_25310V3.1; Pp3c4_25310V3.1; Pp3c4_25310.
DR EnsemblPlants; Pp3c4_25310V3.2; Pp3c4_25310V3.2; Pp3c4_25310.
DR EnsemblPlants; Pp3c4_25310V3.3; Pp3c4_25310V3.3; Pp3c4_25310.
DR EnsemblPlants; Pp3c4_25310V3.6; Pp3c4_25310V3.6; Pp3c4_25310.
DR Gramene; Pp3c4_25310V3.1; Pp3c4_25310V3.1; Pp3c4_25310.
DR Gramene; Pp3c4_25310V3.2; Pp3c4_25310V3.2; Pp3c4_25310.
DR Gramene; Pp3c4_25310V3.3; Pp3c4_25310V3.3; Pp3c4_25310.
DR Gramene; Pp3c4_25310V3.6; Pp3c4_25310V3.6; Pp3c4_25310.
DR InParanoid; A0A2K1KPX4; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000006727; Chromosome 4.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727}.
FT DOMAIN 493..653
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1432..1882
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 93..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1884 AA; 211794 MW; A22FCB58A97A3CF8 CRC64;
MGEIALNGHR FRRIPHPYSL QSTDLELLSN GNLEPWPHLK ELLLSYTAEW VKDELKYGRY
ESVPPPTFEN QIFEGPDTDV ETELRLSNIR LGRHGDATND EDPTTSGRFS QGLFSGRFSG
RSTASDVPDS TVSKAPKHYG GAPLPPYEPV FNWRATRGSV YGQRTPEIPS ALSPSGGLRI
SVKVVSLNIQ AGLVEPWYGT VCLYHREKRE KLSEDFHFRC LPAEFQDEAS GYQRKAIFSL
EAPSPAICLL VQLEKHVTEE GGVTPSVYTR KEPVHLTQRE KQKLQVWARV MPFREPFSWS
TIPLFDANIT GGVGGFSSSP TSSPLPPGIL GSALMEASLD SDGKLIADSK TESASVPVLV
DVPGLHRVKE NYTEEMLQDP KRKVHKPMKA TLRLEIERLS NDDHEADCIS ECGSFGNGSY
DADSRSIGGA SLSGRSTQGL EFTKALYNGH QKGSPVHREL HSSSGSSLEL GRSEFRAVEF
RLGLKPEPLP QLLHCLYVYP QSVNLNRKRN LFIRIELRND DSDIRKPPLE ALYPRDADSS
MQKYAHSQID ANTKNVHFHD EFKVQLPAKL SREHHLLFTF FHVDLQMKLE APKPVVVGYA
VLPLLFAAQV IRLDGTLPIA RELYPNYLLD NVKDRLEYLD DGRTVFKLRS RLCSSLYPVN
ERIRDFFSEY DRHVLRTSPW GNELMEAINA LKHVEASAML QFLQPCLNML LRMIGDGGET
LQVAAFRSMV CIISRVQAET SDGAERNRYL VHYLDFAFDD FGGRHDPVYP GLCSVWRSLA
RSKAKGYRVG PVYDDVLSMA WFFLELIVKS MALEQSRSYC EAVPPGEELP PLQLNDEVFK
SIGQLYDCLL TEVQERGKKG LILAKKLNSS LGFFCYDLLS VIEPRQVFDL VALYFNKFSG
VCLSAMHEYK LTFLRIICDH DLFVEMPGRD PSERCVCLDL PQMNYLASML MQELFITFDH
EDPALKAKAC RIFVQLLCKH EYDARYQTLD DKLYISQRYF PLIGLILDEM PVFYALSPAE
KREVLVCVLH ILRFLDDASL MKAWQQNVAR TRLFFKLLEE CQELFEYKKA GADGLMGAMP
ANEQGDGPLQ YSEKLSPAIN HFLAEASRQD VRLTKSSPGA QWLVQQASPD SSTFWKRVSP
ISNSSSSPSQ PHSLREALAQ AQSAGRGGGR PLRESLHPML RQKLELWEEN LSAAVMLQLL
EIVEKFMAAT AGQAVATDYS RLDCITSIIT GFLGRSQPLP FWKAFLPVFK NLFAQHGAIL
MSRDNDRFLK QVAFHLLRLG VFRNESIRKR AVVGLLILVR TAFQYFKGLS RLRVLLTITL
SELMSDVQVT QHRMDGSLEE SGESQRLRRS LRQIAQENIN ADLLRECGLP EDTLSIMPEG
EFEQSWSWTG VAELSSTLLK AVEAAVGHAL LGPEVMTTDK YATAEAYYGL ARAYSNVPDL
HIMWLLYLCE VHQGNQSYAE AAQCAVAVAG VIMQAIVGKG DHMWGKEHVE ALRKICPMLT
GASFGEAASA EIEGYGSSKL TVESAVKYLQ LANKLFVQGE LFHFCAGILE LIIPVHKARR
AYGQLSKCHT SLTSIYEAIV EQESSPIPFT DATYYRVGFY GKSFGSLNCK EYVYREARDV
RLGDIMRSLG NIYEPRVIDG KQSLHIIPDS RQVKVNDLQP EICYLQITSV EPVTEDEDLE
CRRERQSCRS AATVSARVYN RFLFDTPFTK NGRSQGGLED QWKRRTVLWT EGPFPALVNR
LTVVKSESRE FSPIENAIGM IETRTAALAG ELDDHRLNEG DHLPRLQSLQ RILQGSVAVQ
VNSGVLGVCA AFLSGEPATR LKPQELQQLI AALLEFMAVC KKAIRVHARL IGEEDQEFHS
QLVIGFQSLT AELSRFIPSI PSDL
//
