ID A0A2K1KQE7_PHYPA Unreviewed; 1458 AA.
AC A0A2K1KQE7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=PHYPA_006878 {ECO:0000313|EMBL:PNR55981.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR55981.1};
RN [1] {ECO:0000313|EMBL:PNR55981.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c4_28500V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR55981.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c4_28500V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c4_28500V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; ABEU02000004; PNR55981.1; -; Genomic_DNA.
DR STRING; 3218.A0A2K1KQE7; -.
DR PaxDb; 3218-PP1S247_51V6-1; -.
DR EnsemblPlants; Pp3c4_28500V3.1; Pp3c4_28500V3.1; Pp3c4_28500.
DR EnsemblPlants; Pp3c4_28500V3.2; Pp3c4_28500V3.2; Pp3c4_28500.
DR Gramene; Pp3c4_28500V3.1; Pp3c4_28500V3.1; Pp3c4_28500.
DR Gramene; Pp3c4_28500V3.2; Pp3c4_28500V3.2; Pp3c4_28500.
DR InParanoid; A0A2K1KQE7; -.
DR OMA; EFAVMLC; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000006727; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727}.
FT DOMAIN 865..1080
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..733
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..756
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..807
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..835
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 159232 MW; 4A6EE6AE20C4A58A CRC64;
MSRAGKSGSR AIDKELEDDS RVNGAAQNRK QQKKKGKKGG RFDEDDDFDA IDGAAPSVGS
AEADEAMDPS AAKKKNKKKG GTKKGGFSVL DEEVSDSEAA SVNPAEVEKD EAGEEDSVMF
AGRKKGKKGK KDKKASMDDD YPILDPEAEA VVEEAMDIPA AKTKNKKKGG AMKGGFSLLD
EDMSDDEVAS ASPVVPAVDE AEEEETITFA GKKKGKKGKK DKKASMDDDY PILDLEAEAK
AEEVEEAADL SSAKRNKKKG GAKKGGFSML DEDASDGEVA SVSPVVPDVD EAEEEETITF
AGKKKGKKGK KDKKASMDDD YPVLDPGAED EVEVQAAIDS SAAKKSSKKG GAKKAAFNML
DDMSDGENAS GSPVVSAVDE AEKDEGGEEE TLMFAGKKKG KKGKKDKKAS KDDEDIDGLI
EELGGHTITE AAAPVPAPAT VPAEPKGKQK KKGKKSGRTV QEEEDLDAIL AELEGPSKPA
PPAVSVPEAA APAPPESSAP LAEDEPTAAG GAPPEAEEVV ESAAAKKKKK KKEKEKAAKG
GAVDKPAEEV AVEEKKATAK ADEAKSKAAD KKVPKHVREM QERLARMKEA EEKRLQEEEE
KRRKEEEEQR RLEELERQKE EAKRRRKERE KEKLLQKKKD GKLLTGKKKE EARRLAIMRE
QFGIVADQDS PTGEEAPAPR KPKYETKKKR KPAGQTSAVP AEGEMAEPAV QEPEPEVEPE
PEPEPEPEPE PEPVPEPEPA APMEVEEDEE EEWDAKSWTE EVNLPAIKSA FAEEEADDGP
VKAGQVTVPP PSAPAAATKP SSPKKKPAPP SKSQAKVVDS EEDEEEDDDD EDSEDDVDVK
KRQQAKVRRE ARRVEALKKR SAEDLRSPIC CILGHVDTGK TKLLDCIRRT NVQEGEAGGI
TQQIGATYFP MENIRERTKE LKSDAKLRVP GLLVIDTPGH ESFTNLRARG SSLCDIAILV
IDIMHGLEPQ TIESLNLLKS RHTPFVVALN KVDRLYGWKS CPNAPIRNAL KLQSKDVIGE
FEQRVAFVIT QLKEQGLNSE LYYKNKELRK FISIIPTSAI SGEGVPDILM LLVQLTQKLM
EEKLMYISEV QATVLEVKVV EGLGTTIDVV LVNGVLHEGD QIVVCGMQGP IVTNIRALLT
PHPMKELRVK GTYQHHKELK AAQGIKITAQ GLEHAIAGTQ LYVVGPEDDV EDMKDEAMQD
MRNVMSRIDK SGEGVCVQAS TLGSLEALLE FLKSPAVKIP VSGISIGPVH KKDVMRASVM
LERKRKEFAT ILAFDVKVTA EAKELAEEVG VRIFTADIIY HLFDQFTAYM NSVKEEKRKE
ASEEAVFPCV MKILPQCVFN KKDPIVVGVD ILEGVAKVGT PLCIPSRDGI DIGKIASMEI
NHKVVDTAKK GQTVAMKIVG TNAEENARMF GRHFDLEDEL VSRITRRSID LLKENYRDDL
TTEEWRLVVK LKKLFEIP
//
