ID A0A2K1KXI0_PHYPA Unreviewed; 2463 AA.
AC A0A2K1KXI0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=MI domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPA_005464 {ECO:0000313|EMBL:PNR58469.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR58469.1};
RN [1] {ECO:0000313|EMBL:PNR58469.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c3_36480V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR58469.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c3_36480V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c3_36480V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR EMBL; ABEU02000003; PNR58469.1; -; Genomic_DNA.
DR STRING; 3218.A0A2K1KXI0; -.
DR PaxDb; 3218-PP1S96_61V6-1; -.
DR EnsemblPlants; Pp3c3_36480V3.1; Pp3c3_36480V3.1; Pp3c3_36480.
DR EnsemblPlants; Pp3c3_36480V3.3; Pp3c3_36480V3.3; Pp3c3_36480.
DR Gramene; Pp3c3_36480V3.1; Pp3c3_36480V3.1; Pp3c3_36480.
DR Gramene; Pp3c3_36480V3.3; Pp3c3_36480V3.3; Pp3c3_36480.
DR InParanoid; A0A2K1KXI0; -.
DR OrthoDB; 1123866at2759; -.
DR Proteomes; UP000006727; Chromosome 3.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF9; EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 2097..2221
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 2290..2462
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1200..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1845..1922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1943..1962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1999..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2056..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2004..2034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2463 AA; 264953 MW; 99A23C4AF2BAA053 CRC64;
MSHYLSKGDR SEAQLRKAGR GSAGHPRAGG GQPIPVKGGG PSPFNSAPSG GGPPQPSSFV
ASSARPAAVA ASINRGGKRA NGLPASGGGP PEQGANNKAH QQAALPLHHN NQQQQATGVR
QGVGSADANQ HSQMGAPQLN SDSKGVTTAR TSGNAGTGAP PAIKQLQTSK PPAPPASITT
GSGADTPSAA PPPVSQSSQN PISFQFGSFE PSGFGGASTS GKSSVTPYPL RTNSAPPNLD
EQRREQARFE LRPSSITRVS ASGQQHNAQV TTRNVVSGME PSPTTVPPVQ AATSSQGPIP
VAPTAQALPP QQLGQSPHYP QHLQVNSLHM PSQHILQIQM QQQQHHQQHQ HQHQLHQHQL
QQQQQQQQQH QQQPMPPQQG MAQQSLKYPQ SMMAAPHHNS QMLGTHPVVN PLPPQPMAQM
THQLGPGQIP SGISVGAYGT TTNQFVTKQR SRAIPIVNPL THEELKIDLL KKDSVESVPS
SSLGTAGRVP SNGPMQQLRA PVGYSPPTHP VYYFPSHPQM YPPSIPKTGT FGGAPLSSSP
PVRYSFNPPH PGQGVHAGTT PVPPGAPKVA PQLGPGPPLG SANQVPTSGE ILSTPPVAPL
IMVGPPSSVT VPGIPAVIGN LRPIPPPLVM NPPIVSNGRP PSLTLPPVSP PAPLTPSSVL
PSPNSTVGFK FGDVEASGST PVATGEASSE GSLNGVIGHA STRVEPNNAS GNAPIVGVVA
SSTSPEASDL VNRPAVTVIP PKPGSGNSNA SGISPKIKTP PGTGSAGAFG EKVKSEAVKS
SGNPNTRKSS KKDRQRQQQQ ALAANLPISE GAKTSDQLIS PGLGVSGGHK SGLQRTQSGA
HGSSAVYTPV KNLGSKPEEP KLPNVNFGSQ NSVQDTTKEN TESLAVEEVV AGKDEVESVP
VRPLHEESKG ETPAEIETSL KTDASVLISD GSTASTSSTG LPSLLVKDEP AEVQANELAV
VEDDVPEDVR VSVNPSAASS SFDQELVKVE TNSIEVEPDT ITSEPTFYKA STEMAIENEG
VVNDAEPTVA DLRKENAGFV EQVDPPSSEA DHALTGESAV EWAPDVPDVN EDVSTMKDLP
TPLHSESAPG SKGTGGSEVV VIEESGVLAV DINSVEENDV ADIQVTSSKY VPEVVPGSPL
HSNLDTCMFE NKMVSSQQDS ATALNTTEET PQAVEVATAE EALQSNPSSG GMMIFTSEEV
QSRDSLGPLD SIRGSLENGG EDSRPSEHTE SAASNSSKAE DTAPLIVGES RSEVQTTPLL
SSTSGMSSTE VIETLNAVES EADSVEPAVV GNPTSGQGEG PKVGSRKKKS RKEFLARADA
AGNTADLYNA YKAPEEKKSV EVKQAEVSGA GPSGNDAKDS AITPDKSLPN EVDDWEDAAE
LPTPTISFPH LVDTGDRKYT RDFLMTFKDQ NREFPPNFEI KHDITDVLLD KDKLFSDGLT
SPARNLDWQP SGGQRLERRG SGIQLGPDED RWIRQSGVVP SPGRNQPGDA RMGMDIPGGF
RPGQGMQSGL ISQLPQQWPG MPAQAGFPGL ISRGNMPLGH YMTPGPPARS PNGVDGDRWL
RQPMSGVKGP GLIPSPRTPL PAIHKAENRY EVGKVSDEEQ AKQRLIKGIL NKLTPQNFDK
LFVQVQEAKI DSATTLTGVI SQIFDKALME PTFCEMYAQF CVKLAADLPE FNENDEKITF
KRVLLNKCQE EFERGEREQE EAEKDEEEHV EIKMTPEERE EKRLKARRRM LGNIRFIGEL
YKKSMLTERI MHECIKKLLG EYHNPDEEDV EALCKLMSTI GRIIDHHKAR EHIDAYFRRM
ESLSNNTKLS ARIRFLLKDV MELRRNGWQE RRKVDGPKKI DEVHRDAVQE RQNASRGDRL
GRGPSMGGGG SRGRMGSGPD FVIRGPPSPM YSPGPMGSGP PMGGMRRAPS PQGGMRGGGG
FIQDVRMEDR SLMMDARPVP MPLSQRGADE GSITLGPQGG LGRVGVRQLS LSTGRSALSD
AVPTSGSDTR RLSLGSILGH AQDRSHYSNR DELPMRPSSA ERPRSAERPV LDRPIGADRL
SPGLRDFRST LEQQRLVERS NSLSSSSSTF QPHRTEHTAP FVSVRPSSAP SALSVEELKK
KWESTINEYY SVTDLKEAAL CVEELKAFKH HPEMVDIWVS ESFEKKDRER DLLVKLLLHL
HRIDPPFLSR DQIEIGIDRV LSRFTDLVVD VPKAPEFMGV LLGRLICAGV FTLNEVGNLL
QVAGESRGEV REEGYALRIF GAMVDTYREE KGEEQMVDAY KRSDLDVENF VSPSEKNRET
ALQQFLERTN LHKLHPMLPL ERYIKDSLDR KVPVMDIIKW IEKNVPSAYS EPSFMRMLMT
QVLRRALPDP QSTDISSSNL KVDIKAYAPL LKKCASGGRA TANQIQYIIA ILLFTNECGH
PQGLMTKLFE NFSQEEVISK KAYTDWYDDV NDSTPGRDKA IREVSNWLKQ KIEEGAEVED
EED
//
