ID A0A2K1L2T2_PHYPA Unreviewed; 613 AA.
AC A0A2K1L2T2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Transmembrane and coiled-coil domain-containing protein 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPA_003127 {ECO:0000313|EMBL:PNR60334.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR60334.1};
RN [1] {ECO:0000313|EMBL:PNR60334.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c2_23890V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR60334.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c2_23890V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c2_23890V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; ABEU02000002; PNR60334.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1L2T2; -.
DR PaxDb; 3218-PP1S135_56V6-1; -.
DR EnsemblPlants; Pp3c2_23890V3.1; Pp3c2_23890V3.1; Pp3c2_23890.
DR EnsemblPlants; Pp3c2_23890V3.5; Pp3c2_23890V3.5; Pp3c2_23890.
DR Gramene; Pp3c2_23890V3.1; Pp3c2_23890V3.1; Pp3c2_23890.
DR Gramene; Pp3c2_23890V3.5; Pp3c2_23890V3.5; Pp3c2_23890.
DR Proteomes; UP000006727; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 263..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 106..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 65890 MW; F08570DA60D6BB90 CRC64;
MAELGSVHRY AAGGLFALAL SQAQIQPRAP LEHPSVGGSD DHPQPRTPFL DAEEVSWCDP
DHGLLRHVFR FLGIDEKAWI GLEMTAMSPD SKHQIGAFLR LLAEDESEPS SSGESRRMME
SAASSDGVGT LRRHEDSSVV NVKGKDRAQE FEESSEYYSR FSEAEIMTKQ RKIEIMHELV
MACVSGFPNG KGLKVTKYGY DARQRVALRL LALWLNIKWS KVVSLELMVA HTAMDAHKKR
EQTHNDDEEV AKSRWQRLKR GSLIGGAAVT GGVLLAITGG LAAPAIAAGM AAVGTAVPAL
GAGGLAAAAA LAGSTMGSLA VAASFGAAGA GLTGFKMARR TGGIEEFQFV PIGDNHQQGR
LAVAVLASGI VFDLYDYIEP WEAPDGDLER YALQWESEHL LAVSTAIEDW LTSNVAIQLM
SRGAMYTVLG GLVAALAWPA TLLSATDFID SKWTIAVDRS DKVGKLLAKV LLKGAQGNRP
VTLIGFSLGA RVIFACLEEL AKEGNQGGIV ERVVLLGAPL ILNKPRWEKA RQVVAGRFIN
AYSTSDWMLG VVYRANFLSQ GLAGLQAVDV PGIENVDVTD LVNGHSSYLK KAGDIVQALD
IDSFYPTHNC KLQ
//
