ID A0A2K1L6G3_PHYPA Unreviewed; 3760 AA.
AC A0A2K1L6G3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=PHD-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPA_000046 {ECO:0000313|EMBL:PNR61623.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR61623.1};
RN [1] {ECO:0000313|EMBL:PNR61623.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c1_860V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR61623.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c1_860V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c1_860V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABEU02000001; PNR61623.1; -; Genomic_DNA.
DR STRING; 3218.A0A2K1L6G3; -.
DR PaxDb; 3218-PP1S200_118V6-1; -.
DR EnsemblPlants; Pp3c1_860V3.1; Pp3c1_860V3.1; Pp3c1_860.
DR EnsemblPlants; Pp3c1_860V3.2; Pp3c1_860V3.2; Pp3c1_860.
DR EnsemblPlants; Pp3c1_860V3.3; Pp3c1_860V3.3; Pp3c1_860.
DR EnsemblPlants; Pp3c1_860V3.5; Pp3c1_860V3.5; Pp3c1_860.
DR Gramene; Pp3c1_860V3.1; Pp3c1_860V3.1; Pp3c1_860.
DR Gramene; Pp3c1_860V3.2; Pp3c1_860V3.2; Pp3c1_860.
DR Gramene; Pp3c1_860V3.3; Pp3c1_860V3.3; Pp3c1_860.
DR Gramene; Pp3c1_860V3.5; Pp3c1_860V3.5; Pp3c1_860.
DR InParanoid; A0A2K1L6G3; -.
DR OrthoDB; 1216725at2759; -.
DR Proteomes; UP000006727; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04369; Bromodomain; 1.
DR CDD; cd15519; PHD1_Lid2p_like; 1.
DR CDD; cd15489; PHD_SF; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR47162:SF10; METHYL-CPG-BINDING DOMAIN-CONTAINING PROTEIN 9; 1.
DR PANTHER; PTHR47162; OS02G0192300 PROTEIN; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 223..274
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 586..657
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1743..1790
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1863..1913
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1818..1856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2078..2101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2238..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2302..2350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3118..3171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3322..3341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3362..3384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3720..3760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2247..2263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2324..2345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3118..3165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3203..3218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3225..3278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3720..3739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3760 AA; 409525 MW; E25ED3A629D1F801 CRC64;
MDASLRRECS APEVPLQVEA SGGTEAGYNI GKQGTSGVLE AQPTGVSSVE PMQNAEASPL
DGSSKMPVHV SKGGTNENFR VFGSSTAENL VMPTLQNSDN GNVETLKKEH VLSLKKSSIE
NGAKRESELS NGSKGVLKDI PPKSQVPMRK LARKSGLLKS ETIPAPKTEL SVADAVKEGI
LKKEREEQDR KEAVDAVMEI HGVRKQVTGH AVSFPGVAGP ESGRLCHCCS RPESSKSTIF
CDKCERGFHV DCVKHWPKPA QELDVWHCGP CGLQPGHYWP LGRVLIIYDN AVAEYKKYSS
SFLTTLQRKE ESSFGTFSQG MGQTTHEKSD GLEGVAKVKV IRDFKKEARK GNSKVSKAVT
SSVSVVSKAG PGMPLHVKEF GSVTDIEASG ESVQQPKPLS YSGFVPIQPK SSLSSIAPIV
NFMVPPEANA VKTLTSPNVP IPPSHQSRNI LLFNEFTVSS TPGFSHTGSI SSHVAEPKVL
YTTSKDSTGP TALSSKIEIA SVRSQHQKTS VMDQYAASPK PNLLGFSHLS STPNQMSVQQ
KTALASGAVS IEVSSTERLR PFAVGERLTE REELLKEAKD SLNQLRTFIT ALKGNLAEDW
RVILRKRPTG AQEKFYLSPA KRKYRSRQDV ARFLGLVDDP KCQRTKPCNL GTSLDKPLDK
NNSHPPASQA NAVTNLPMFC GDVMIEKLGV IDSRPTYSDE HHIWPVGFRS SWHDPETRSY
CISEVEDGGE LGPIFRVTRK LVIVPANGKN DLLATSSLGE AALDISGIPV EPKKVKIWED
ISSSHEVTSE VVSAKIGDSS IFKVPTEGNQ IDAQKQHTEV FNKHASKFGV NIEAGSEKEG
VSQFEEAREG KTSIMNGDPS SASSTKQILA SHSIGQSIID LTEEKELPLK PHSETVLDIK
VSASDVKGDL STIDVTKDAC ASENVKVNLH HSETPPVVIE LSDEEDEKPS SLVFSDKASA
AAREGPGKAS GFSLPHIKPL PNNLMEELTV EARRPGEAWK VFGKKFVEQC KKSLGSGLNC
AVPILDATND YVIYNSGTST LWDGSTDIAN AALLNQKSVD GSETTKALFY DRLEKRLGED
RFGLNLPVVQ NMIKALRIGK PAGYDEAWVK GVDQIDEAAH TASLSLPSQI KETAVTPSDP
WKRKKRKKNL DLLAEGNVKK GKPSSAEPAA LHPLDLRAGE QFGIEKVVFR NLPPVSSTPT
PLLASAIGLG QATGPITTAV AAAAAAAAAA PPPPVVIIEE PRQPPPAGEP ILKRLPSELV
GDLLQVWEFL CRFSDLFGQD VRFTLEDLEA GLLDVGPVRE VEVTTEAKDC SELSGRKGRV
STVVDFSEPS VRTGREGVEY VVDLSESSER DPMKGDKVLN KFIGTADRSH ESAEVPDLGQ
GFNAVMGIVE DAEMKEECCE DLKLEGKESN LHALEEEQSG TKNAVEVFKG TVSKGIAFLA
EAHIPLLKFL VSDLKFRISR GLNEDEVEEP KKRGRKRICD VGPLPPEFGD DLPMNAVTWP
EVAHRYLVAI LDVKKHGDIT ELAPDERKKL MRYFEGDGGV MGGAVEGVVG VESDAQVLAE
AEKELTVRMP KTVEKDIVIF VPQEWDVALT PINPAPKKAK NRKTGDLDPL PKWVEALEPV
RKMPTNLGTK LKLQVQEALD YDPPDWAKGT LEWSLSKGTF KSNAAGTTKR AVLEVLAQYH
GEELKAINAP RIRKVKAAPS AEHLMQRCRI VLREVAKADS KQVFGNLMGG ASAVKSSKDV
GTLARPLDFR TIDARLAAGA YGGSTDAFAA DMRQIWKNVE SVHKSGSAIL ELANTLSQLF
EKLYLKQVVS LIKGMPDTKD DKEKVSDVDT KVDGSVRSNS KAGTKGSGNA ADDKLGKAPW
EDDTTCRVCG VDEDYDSILL CDGCDAEYHI YCLVPPLEKV PKGNWFCPSC VAVEEGYPEA
PSLGEAELRE MQEEKERPVA GSILKLEYED EKVPSIVLEK KPEAEKIGRE LRSGIVAGLA
VEDEALCEEP DAHFPAVEIS VEALLKKLEE KDYWQLSLPD KLFVLKFLCD EALKTPQARA
HLEKSVEVTL ELQQQLRDLV AERLKIVVPM DVIGHTKPID KDNLQKPQTN SLPGPSLDTT
ELKDGVGTAV RASGLELESL GVAETPKLTT VSFPTSNSDD DVLVIGKFSS KTITQENNAG
VGKVVHDLDL NVEAGKEPEP DHLRSDHNAS FGTSPVELNK ERLLVKGFEN TKPVELDAVT
ASQTENTVKV ILNQLSPDQK PGLLQDSEQR ASEHHGRARE SDSGRIHVAS VTEGVEDVVT
IQPDAASRPL NPLKRSLVIG ESNLPSTSMN GPENVKKAKK EENAIQSTPS GIHGTETNDP
IKEPSDAQAT ASKILEDKDA RTKALQTARE LDMKITKLGS KLFNLTLRRE HIGTDHLGRE
YWALTGIDGR PCLVVADTSA PQERAGQGTN SGSCSQTVEF QGIEDRTTSP IVPSVSKGSS
EDKEKDVLNL KTMQERTKWV HYKGDKALDE LVKWLSPRDQ HERVLRISIY HWRRSLYPRH
LLYMPDMKTA VTTTEPSKVV DESRAIKETP FSEMEEISHI RSFPAVNARK LLLKRHTALN
TSSRSDLVHQ KESHDSKEIL DKKSSVLRRC ECLELLWDSR YHCLSCHETY ESSAEFQTHS
NDCPPGSKPS TENGCKDTPA LIPAKAKKVA HDSRKLAVKM KKLTSFDKAS DLSQSVAKVG
ITTRSERLRR VLKRESLQPT VDDDVDMDPA ESMEFLPKNV ESLQTQKILS TGGGNPIEHT
STGLSKALEG FINPSSSTVL PHASGQPVEP TQEPRVEADT FEVTFTVDDF DANSSPSQFG
VRSEKRISDS NQLHELKVLN TNQLNLNCSN NRHNGQGNAG LWVDDLNISN PGARGTDLNA
NQFNCSNNLH GNQGNSGGWV NDLNISDKQV RDQELFHSQS NCSSISRNRQ GNNGGWMNDL
NISSHSFSDQ VMDFNSLKYA SSSQGGRGNS GGWANDLNVA TQAFREDASL FGYHPPAPAL
ISTPGSGRER ASQIKFLNRG PSFASPVQSH LAFDSSLMVG SSPAYPSMES FNSLETSNPV
ASQYQQFLSS RNTLSQAPVP NSNFLLSLNG TNPKSVSYNQ YLTPLDHANS QQLSFQQLLS
SNDSLSTSPS SYPDSLPSPE NANTTPLSHS NLIHSRDSRN PQPVLYSQGV LPPENLNFDS
TSKSPALPFP NLKYTNQSTA PYVDLNPNFN QPGSRPGDLN IHSNPALYAN LNPNSNPSTS
RHASLNMNSS PLYTNFSTNS HPSASHHTDS SINPNPSLTT DLNISNPLVS LCSQLSLSNN
LVDSETKNFE VGRFKSNSWF DSQSTPKPLT VERPPVIPTK PTARRSATWD YLINLPLSSS
QGSERLVQKH HESSGRHSSP SPIEVGSLPF DLVFDKPKRE DLNESTVPEV YGTLTLDRML
DGQQVQSQIN NSCRDTVSMG AGSVTLDLML EKQEQEHGVI RRTTGSSEFG ALSIDLMTVP
EEQMEIALAD TMDIAEGRCI DGVQVEPVEA AKETRSGNVP DGCSGAPKES CAVAAPAIPP
GNDKLACKDQ VEGQGEAGVD RVEVEQGEGN TSSEQRILLP PSVPVAGASS ARKPVKRFPV
ANASVHPLVG EQKYLLKGLQ ISLLDMEAAM VNDILESARA SPIRRRAWRA FVKSSSCIYE
VTKAIILLEL MVKADCLKPS WGYWSSFSAA ARSSSLSSLA LRLFALDSSI AYEWVKAAED
GKETTLPSKS SKAKKKKPSD LPLPPPPPLP PKQKKKKKKK
//
