ID A0A2K1L861_PHYPA Unreviewed; 557 AA.
AC A0A2K1L861;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=CBS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPA_000647 {ECO:0000313|EMBL:PNR62223.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR62223.1};
RN [1] {ECO:0000313|EMBL:PNR62223.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c1_14290V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR62223.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c1_14290V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c1_14290V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; ABEU02000001; PNR62223.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1L861; -.
DR STRING; 3218.A0A2K1L861; -.
DR PaxDb; 3218-PP1S86_26V6-1; -.
DR EnsemblPlants; Pp3c1_14290V3.1; Pp3c1_14290V3.1; Pp3c1_14290.
DR EnsemblPlants; Pp3c1_14290V3.2; Pp3c1_14290V3.2; Pp3c1_14290.
DR Gramene; Pp3c1_14290V3.1; Pp3c1_14290V3.1; Pp3c1_14290.
DR Gramene; Pp3c1_14290V3.2; Pp3c1_14290V3.2; Pp3c1_14290.
DR InParanoid; A0A2K1L861; -.
DR OrthoDB; 1328303at2759; -.
DR Proteomes; UP000006727; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd17781; CBS_pair_MUG70_1; 1.
DR CDD; cd17782; CBS_pair_MUG70_2; 1.
DR CDD; cd06409; PB1_MUG70; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13780; AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR13780:SF125; MEIOTICALLY UP-REGULATED GENE 70 PROTEIN; 1.
DR Pfam; PF00571; CBS; 4.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00116; CBS; 4.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 2.
DR PROSITE; PS51371; CBS; 3.
DR PROSITE; PS51745; PB1; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 530..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..129
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 137..192
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 238..298
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 423..510
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
SQ SEQUENCE 557 AA; 60494 MW; E639AA9F0A6A0375 CRC64;
MSSGTGSEGR VGAIDLAKRS ISSRSYARSV SATVPSGDLL LKKLSQGNGT VIPRCRSRSV
VSGERTVKRL RLSKALTIPD GTTVADACRR MATRRVDAAL LTDSNALLCG IITDKDVAIR
IIAEGLKPEE TSVSKVMTRN PTFVMGDTLA VEALQKMVQG RFRHLPVVEH GEVVALLDIT
KCLYDVIARI ERAAEKGNAL AAAVESVERE WSVKGSDESN FIQNLRDRML RPTLRSLIAE
VASVPTCSPS ETVTVASKKM KEQQMNSVII TSSCSKPIGI LTSKDVLMRV VAQGLHPETT
TLDKVMTPNP ECAGFDTTLV DALHIMHDGK FLHLPVTDHD GFVVTCLDVL QLTHGAVATA
RGAGSGGQDM ATTMLQRFWD SALALEPAKE GDDSHIDTSE RQSDVFSERK CGYPTFGPGN
TFAFKLKVNS HNGKVGHYRF NCGSESLKNL MTMIVQRVGD DIDRTHLPLL MYVDDEGDEV
LLATDSDLVA AVNFARISGW KALTLHLEEI RIRKAISANR TSSVKNSKGW STLHASFLVC
TVAVALSVVF YIHRTNT
//
