ID A0A2K1WSR6_POPTR Unreviewed; 801 AA.
AC A0A2K1WSR6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=POPTR_019G114800 {ECO:0000313|EMBL:PNS91565.1};
OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS trichocarpa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX NCBI_TaxID=3694 {ECO:0000313|EMBL:PNS91565.1, ECO:0000313|Proteomes:UP000006729};
RN [1] {ECO:0000313|EMBL:PNS91565.1, ECO:0000313|Proteomes:UP000006729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX PubMed=16973872; DOI=10.1126/science.1128691;
RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA Rokhsar D.;
RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL Science 313:1596-1604(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; CM009308; PNS91565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1WSR6; -.
DR STRING; 3694.A0A2K1WSR6; -.
DR InParanoid; A0A2K1WSR6; -.
DR Proteomes; UP000006729; Chromosome 19.
DR ExpressionAtlas; A0A2K1WSR6; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF588; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006729}.
FT DOMAIN 23..189
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 801 AA; 90804 MW; BECD021C5D742CC1 CRC64;
MFAYISQSPS TPSTLTTGHP KGIKHDVFLS FSEQDTLAGF TSHLYAALDR KQILTFIDYQ
LVRGDEISAS LLRTIEEAKL SVIVFSENYA SSKWCLEELV RIFECRKNNG QIVIPVFYKV
DPTHLRHQTG SFGDAFARLI RNKALTLEEV QSFRDALTDA ANLSGWSLGN SGPESEFIEK
IVGDVLKKLH AMSSSHTMTG LFGIDVRVSK VESLLNMESP DVLIIGIWVM GGIGKTTIAE
VVRDNIRSRF ERIFFANLRQ KSDLRRKFLK RLLGQETLNT MGSLSFRDSF VRDRLRRIKV
FIVLDDVDDL MRLDEWRDLL DGRNSSFGPG SKVLITSRNK QVLTNVVDQT YKVGGLNYEE
AIQLFSSKAL KTCIPTIDYR HLIEKIGRHV QGNPLALKVL GSSLYGKSIE EWHSALNKLA
QHPQIEKALR ISYDGLDSEQ KSIFLDIAHF FKGRMLILDC FYGRSVKFDI STLIDKCLIS
IAKDSLFGDK LEMHDLEFIE ELNLSGTAIK EVPSSIQFLT RLIMLDMSGC SELESLPEIT
VPMKSLLYLI MSKTGIKEIP LISFKHMISL WSLKLDGTPI KVLPELPPSL SRLRTHDCAS
LETVTSIINI GSLWDFTNCF KLDQKPLVAA MHLKIQSGEE IPDGRIQMVL PGSEIPEWFG
NKGIGSSLTI RLPSNCHQLK GIAFCLVFLV PLPFYKVYYN YHVKSKNGKH DEVVFASREE
LTLTDVLVSC DSYHMILHYE LELVKHLRKH SGNEVTFKFY HLEEDDCGRK LGRDIRRPFK
LKSCGVYLHF DENLLADTDL P
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