ID A0A2K1X0G4_POPTR Unreviewed; 1575 AA.
AC A0A2K1X0G4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA (cytosine-5)-methyltransferase {ECO:0000256|PIRNR:PIRNR037404};
DE EC=2.1.1.37 {ECO:0000256|PIRNR:PIRNR037404};
GN ORFNames=POPTR_018G138000 {ECO:0000313|EMBL:PNS94276.1};
OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS trichocarpa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX NCBI_TaxID=3694 {ECO:0000313|EMBL:PNS94276.1, ECO:0000313|Proteomes:UP000006729};
RN [1] {ECO:0000313|EMBL:PNS94276.1, ECO:0000313|Proteomes:UP000006729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX PubMed=16973872; DOI=10.1126/science.1128691;
RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA Rokhsar D.;
RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL Science 313:1596-1604(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|PIRNR:PIRNR037404,
CC ECO:0000256|RuleBase:RU000417};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037404}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family.
CC {ECO:0000256|PIRNR:PIRNR037404, ECO:0000256|PROSITE-ProRule:PRU01016,
CC ECO:0000256|RuleBase:RU000416}.
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DR EMBL; CM009307; PNS94276.1; -; Genomic_DNA.
DR SMR; A0A2K1X0G4; -.
DR STRING; 3694.A0A2K1X0G4; -.
DR EnsemblPlants; Potri.018G138000.1.v4.1; Potri.018G138000.1.v4.1; Potri.018G138000.v4.1.
DR Gramene; Potri.018G138000.1.v4.1; Potri.018G138000.1.v4.1; Potri.018G138000.v4.1.
DR InParanoid; A0A2K1X0G4; -.
DR OrthoDB; 317994at2759; -.
DR Proteomes; UP000006729; Chromosome 18.
DR ExpressionAtlas; A0A2K1X0G4; differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; IBA:GO_Central.
DR CDD; cd04712; BAH_DCM_I; 1.
DR CDD; cd04708; BAH_plantDCM_II; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR022702; Cytosine_MeTrfase1_RFD.
DR InterPro; IPR017198; DNMT1-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00145; DNA_methylase; 2.
DR Pfam; PF12047; DNMT1-RFD; 2.
DR PIRSF; PIRSF037404; DNMT1; 5.
DR PRINTS; PR00105; C5METTRFRASE.
DR SMART; SM00439; BAH; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037404};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037404};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037404};
KW Reference proteome {ECO:0000313|Proteomes:UP000006729};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR037404};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037404}.
FT DOMAIN 779..913
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 953..1092
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..728
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1243
FT /evidence="ECO:0000256|PIRSR:PIRSR037404-1,
FT ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1575 AA; 177522 MW; 92AFFF4651260450 CRC64;
MGSSSILDTT TNDPVDNTIS SSSSVGMRKN KKGKQKSSVS NVKKEVPEKN TKGKKRNSPD
TNKEEPTGGD GSLKRPKRAA ACKDFKEKSV RLHEEKSYVV ESKKEQVVDE EILAVRLTQG
QEEGRPNRRL IDFVVHDANG NPQPLEMVEV DDMFISGIIM PHEESLDKEK EVHVRCDGFG
RIEAWDISGY EDGSPVIWLS TEVADYDCIK PAGGYKKFFD HFFQKALACV EVYKKLSRFS
GGNPEFTLDE LLAGVVRAMS GNKCFSGAVS IKNFLISQGE FIYHQIIGLD ETSTKNDKKF
ADLPVLVALR DESRNHGNVL IAKAANSGGN LVIGPESVDG AVVNQSNQSS TTVEEDEDAK
LARLLQDEEY WQSNMRQKKS RGSVSASNTI YIKINEDEIA NDYPLPAFYK HSNEETDEYI
AVASDDVIDH PDDLPRRMLH NWSLYNSDSR LISLELLPMK PCEDIDVTIF GSGSMTEDDG
SGFCLDDGPD QSSSRGLEAQ DDMGLPIFLS AIKEWMIEFG SSMIFISLRT DMAWYRLGKP
SKQYASWYKP VLKTVKLART IITLLKEQSR VSRLSFADVI RKVSEFKKDH HAYISSDLAA
VERYVVVHGQ IILQLFAEFP DQKIKKCAFV VGLTRMMEER HHTKWVVNKK AIVQKCHSNL
NPRAAMDTVA SGASKRKLMQ ATTTRLINRI WGEYYSNYSP EDLKEGNDCD VKEEDELEEQ
DENEDDDKEV VVEKTLKPYS VFEHCKSHTS QKEVRWDGNP VRKISSGEDI YKQAIVCGQV
IVVGAAVLVE VDEPDELPAI YFVEYMFETR NGSKMFHGRM MKWGSETVLG NTANDREVFL
TNECMNYKLQ DVKQTIILEV RKRPWGHHHR KDNANADRID REKAEERKKK GLPLEYYCKS
LYWPERGAFF TLPFDTMGLG SGVCHSCNLK ISEEDKNISK VNSSQTGFSY KGTEYSVHDF
VYVSPHQFAV ESGETETFKG GRNVGLKPYA VCQLLEVVPM ETKQSETRST EVKVQRFFRP
DDISPEKAYC SDIREIYYSE ETHLLSVEVI EGKCEVRKKI DIPTCSAPAI FDHTFFCEHM
YDPSNGSLKQ LPAHIKSKFS AVSKDGDVAS RKRKGKSKEG ENDTEDDKQL EASPEYRLAT
LDIFAGCGGL SEGLQQAGVS TTKWAIEYEE PAGEAFKLNH AESLMFINNC NVILRAVMER
CGDADDCIST SEAAKMASSL DAKVIDGLPL PGQVDFINGG PPCQGFSGMN RFNQSTWSKV
QCEMILAFLS FADYFRPKYF LLENVRNFVS FNKGQTFRLT IASLLQMGYQ VRFGILEAGA
YGVSQSRKRA FIWAASPEEI LPEWPEPMHV FAAPELKITL SEKSQYAAVR STAYGAPFRA
ITVRDTIGDL PDVANGASKT NLEYGNDPIS WFQKKIRGDM VVLTDHISKE MNELNLIRCK
NIPKRPGADW RDLPDEKVKL STGQMVDLIP WCLPNTAKRH NQWKGLFGRL DWEGNFPTSI
TDPQPMGKVG MCFHPEQDRI LTVRECARSQ GFPDNYQFFG NIQHKHRQIG NAVPPPLAYA
LGRKLKEALD SKRQK
//