ID A0A2K1XHW4_POPTR Unreviewed; 1402 AA.
AC A0A2K1XHW4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=POPTR_015G043600 {ECO:0000313|EMBL:PNT00364.1};
OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS trichocarpa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX NCBI_TaxID=3694 {ECO:0000313|EMBL:PNT00364.1, ECO:0000313|Proteomes:UP000006729};
RN [1] {ECO:0000313|EMBL:PNT00364.1, ECO:0000313|Proteomes:UP000006729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX PubMed=16973872; DOI=10.1126/science.1128691;
RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA Rokhsar D.;
RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL Science 313:1596-1604(2006).
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DR EMBL; CM009304; PNT00364.1; -; Genomic_DNA.
DR EnsemblPlants; Potri.015G043600.2.v4.1; Potri.015G043600.2.v4.1; Potri.015G043600.v4.1.
DR Gramene; Potri.015G043600.2.v4.1; Potri.015G043600.2.v4.1; Potri.015G043600.v4.1.
DR InParanoid; A0A2K1XHW4; -.
DR OMA; MGKREWF; -.
DR OrthoDB; 1211301at2759; -.
DR Proteomes; UP000006729; Chromosome 15.
DR ExpressionAtlas; A0A2K1XHW4; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF595; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS)-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006729};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 18..178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1402 AA; 158262 MW; EC445AD1E592DB27 CRC64;
MAMPHSLMVS SSPAALRLQW DVFLSFRGED TRHGFTKNLY DSLSKQDIRV FLDDSGMTQG
DEIAPTLMEA IEDSALSIII LSPRYANSHW CLEELARICE LRRLILPVFY QVDPSHVRRQ
KGPLEQDFMN HMERFGEEKV GKWREAMYKV GGISGFVFDT RSEDQLIRRL GNRVMTELRK
TPVGIATYTV GLDSRVEDLK KRFIDDKSNR VQVLGLHGMG GIGKTTLATA LFNKLVGHFE
SRSFIFNVKD ISKEDGGLVK LQNKLLGDLS PNWPLVNNID KGVAAIKMLV HEKRVLIVLD
DVDDVSELNA LVGNRSWFGE GSRVIVTTRN KAVLAEHLVN EFYEVRELGD PEALQLFSYH
ALRKDKPTEE YMNISKEIVS LTGGLPLALE VFGSTLFNER GLNRWEDALK KLQRIRPHNL
QDVLRISYDE LDEDGKHVFL DIACLFFKMG MKREEAIDIL KGCGFSAETV IRVLTSKCLI
KIREDDELWM HDQLRDMGRQ IVQHENLADP GGRSRLWDRG EIMSTLMRKK GTESVQGIVF
DFEKKKYTRT RRISWVRALN PCSALAYLIE KCKIFLRRGQ EGEEKKKYTR TQWISWVRAL
NPCSALAYLI EKCNIFLRQG QEEGEMILDT EGFKSMVNLR LLQINHAKLQ GKFKNFPAGL
KWLQWKNCPM KNLPSDYAPH ELAVLDLSES GIERVWGWTS NKVAKNLMVM DLHGCYNLVA
CPDLSGCKTL EKLNLQGCVR LTKVHKSVGN ARTLLQLNLN DCSNLVEFPS DVSGLKVLQN
LNLSNCPNLK DLPQEIGSMY SLKQLLVDKT AISVLPESIF RLTKLEKLSL NGCQFIKRLP
KHLGNLSSLK ELSLNQSAVE ELPDSVGSLS NLEKLSLMWC QSLTAIPESV GNLQLLTEVS
INSSAIKELP PAIGSLPYLK ILSAGGCRSL SKLPDSIGGL ASISELELDE TSISHLPEQI
GGLKMIEKLY MRKCTSLSSL PESIGSMLSL TTLNLFGCNI NELPESFGML ENLVMLRLHQ
CRKLQKLPVS IGKLKSLCHL LMEKTAVTVL PESFGKLSNL MILKMGKEPL ESPSTQEQLV
VLPSSFFELS LLKELNARAW RISGKIPDDF EKLSSLEMVD LGHNNFSSLP SSLCGLSLLR
KLHLPHCEEL ESLPPLPSSL VEVDVSNCFA LETMSDVSNL GSLTLLNMTN CEKVVDIPGI
ECLKSLKRLY MSNCKACSLK VKRRLSKVCL RNIRNLSMPG SKIPDWFSQE DVKFSERRNR
EIKAVIIGVV VSLDRQIPEQ LRYLPVVPDI QVNLLDQNKP IFSTTLYLQG IPKTHEDHIH
LCRYSHFNPL VLMLKDGSEI QVRKRKPPVI EGVELKKCGI HLVYENDDDY GGNEESLDES
QQSVSQKLAN FFNSYEEDSQ VC
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