ID A0A2K1YWD4_POPTR Unreviewed; 1605 AA.
AC A0A2K1YWD4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=POPTR_010G186900 {ECO:0000313|EMBL:PNT17339.1};
OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS trichocarpa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX NCBI_TaxID=3694 {ECO:0000313|EMBL:PNT17339.1, ECO:0000313|Proteomes:UP000006729};
RN [1] {ECO:0000313|EMBL:PNT17339.1, ECO:0000313|Proteomes:UP000006729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX PubMed=16973872; DOI=10.1126/science.1128691;
RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA Rokhsar D.;
RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL Science 313:1596-1604(2006).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; CM009299; PNT17339.1; -; Genomic_DNA.
DR Proteomes; UP000006729; Chromosome 10.
DR ExpressionAtlas; A0A2K1YWD4; baseline and differential.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF34; CLATHRIN HEAVY CHAIN 1-RELATED; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000006729};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 244..267
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT COILED 1524..1551
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1605 AA; 182355 MW; 566990DCEED03BC4 CRC64;
MKAKMKSYQM PEQIVFWKWI TPKMLGLVTQ TSVYHWSIEG DSEPVKMFER TANLQSNQII
NYKCDPSEKW LVLIGIAPGS PERQQLVKGN MQLFSVDQQR SQALEAHAAS FAQYKVPGNE
NPSTLISFAT KSFNAGQITS KLHVIELGAQ PGKPSFTKKQ ADLFFPPDFA DDFPVAMQIS
HKYSLIYAIT KLGLLFVYDL ETATAVYRNR ISPDPIFLTA EASTVGGFYA INRRGQVLLA
TVNEAMIVPF VSGQLNNLEL AVNLAKRGNL PGAENLVVQR FQELFAQTKY KEAAELAAES
PQGILRTPDT VAKFQSVPVQ PGQTPPLLQY FGTLLTRGKL NAFESLELSR LVVNQNKKNL
LENWLAEDKL ECTEELGDLV KTVDNDLALK IYIKARATPK VVAAFAERRE FDKILIYSKQ
VGYAPDYLFL LQTILRTDPQ GAVNFALMMS QMEGGCPVDY NTITDLFLQR NLIREATAFL
LDVLKPNLAE HGYLQTKVLE INLVTFPNVA DAILANGMFS HYDRPRIAQL CEKAGLYIRA
LQHYTDLPDI KRVIVNTHAI EPQALVEFFG TLSREWALEC MKDLLLVNLR GNLQIIVQTA
KEYCEQLGVD ACVKLFEQFK SYEGLYFFLG SYLSSSEDPD IHFKYIEAAA RTGQIKEVER
VTRESNFYDP EKTKNFLMEA KLPDARPLIN VCDRFGFVAD LTHYLYSSNM LRYIEGYVQK
VNPGNAPSVV GQLLDDECAE DFIKGLILSV RSLLPVEPLV EECEKRNRLR LLTQFLEHLV
SEGSQDVHVH NALGKIIIDS NNNPEHFLTT NPYYDSRVVG KYCEKRDPTL AVVAYRRGQC
DEELINVTNK NSLFKLQARY VVERMDGDLW EKVLNPENEY RRQLIDQVVS TALPESKSPE
QVSAAVKAFM TADLPHELIE LLEKIVLQNS AFSGNFNLQN LLILTAIKAD PSRVMDYINR
LDNFDGPAVG EVAVEAQLYE EAFAIFKKFN LNVQAVNVLL DNIQSIDRAV EFAFRVEEDA
VWSQVAKAQL REGLVSEAIE SFIRADDATQ FLEVIRAAED ANVYQDLLKY LLMVRQKTKE
PKVDSELIFA YAKIDRLSDI EEFILMPNVA NLQNVGDRLY DEALYEAARI IFQFIANWAK
LASTLVKLKQ FQSAVDAARK ANSAKTWKEV CFACVDAEEF RLAQICGLNI IIQVDDLEEV
SEYYQNRGYF NELISLMESG LGLERAHMGI FTELGVLYAR YRPEKLMEHI KLFSTRLNIP
KLIRACDEQQ HWKELTYLYI QYDEFDNAAT TIMNHSPEAW DHMQFKDVAV KVANVELYYK
AVHFYLQEHP DLINDLLNVL ALRVDHTRVV DIMRKAGHLL LVKPYMIAVQ SNNVSAVNEA
LNQIYVEEED YERLRESIDL HDNFDQIGLA QKIEKHELLE MRRVAAYIYK KAGRWKQSIA
LSKKDNLYKD AMETASQSGD RELAEELLVY FIEQGKKECF ASCLFVCYDL IRPDVALELA
WMNNMIDFAF PYLLQFIREY TGKVDELVKY KIEAQKEVKA KEQEEKDVIA QQNMYAQLLP
LALPAPPMPG MGGPTMGGGF APPPPMGGMG MPPMPPFGMP PMGSY
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