ID A0A2K2CTM7_BRADI Unreviewed; 166 AA.
AC A0A2K2CTM7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=rRNA N-glycosylase {ECO:0000256|RuleBase:RU004915};
DE EC=3.2.2.22 {ECO:0000256|RuleBase:RU004915};
GN ORFNames=BRADI_4g41501v3 {ECO:0000313|EMBL:PNT65378.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:PNT65378.1};
RN [1] {ECO:0000313|EMBL:PNT65378.1, ECO:0000313|EnsemblPlants:PNT65378}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:PNT65378.1,
RC ECO:0000313|EnsemblPlants:PNT65378};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:PNT65378.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:PNT65378.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:PNT65378}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:PNT65378};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC adenosine on the 28S rRNA.; EC=3.2.2.22;
CC Evidence={ECO:0000256|RuleBase:RU004915};
CC -!- SIMILARITY: Belongs to the ribosome-inactivating protein family.
CC {ECO:0000256|RuleBase:RU004915}.
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DR EMBL; CM000883; PNT65378.1; -; Genomic_DNA.
DR EMBL; CM000883; PNT65379.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K2CTM7; -.
DR EnsemblPlants; PNT65378; PNT65378; BRADI_4g41501v3.
DR EnsemblPlants; PNT65379; PNT65379; BRADI_4g41501v3.
DR Gramene; PNT65378; PNT65378; BRADI_4g41501v3.
DR Gramene; PNT65379; PNT65379; BRADI_4g41501v3.
DR InParanoid; A0A2K2CTM7; -.
DR Proteomes; UP000008810; Chromosome 4.
DR GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:UniProtKB-EC.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.420.10; Ricin (A subunit), domain 1; 1.
DR InterPro; IPR036041; Ribosome-inact_prot_sf.
DR InterPro; IPR001574; Ribosome_inactivat_prot.
DR InterPro; IPR016138; Ribosome_inactivat_prot_sub1.
DR PANTHER; PTHR33453; -; 1.
DR PANTHER; PTHR33453:SF46; RRNA N-GLYCOSYLASE; 1.
DR Pfam; PF00161; RIP; 1.
DR SUPFAM; SSF56371; Ribosome inactivating proteins (RIP); 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004915};
KW Plant defense {ECO:0000256|RuleBase:RU004915};
KW Protein synthesis inhibitor {ECO:0000256|RuleBase:RU004915};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Toxin {ECO:0000256|RuleBase:RU004915}.
SQ SEQUENCE 166 AA; 19263 MW; 3CE18E2497A80CE3 CRC64;
MFFDDVNIPD GVQRQSLGLT SSYLKMLKGD ERDHLRIGKP IIENAYHTLV DYNANLNLKD
RRMRSQRKGL AQMVMMLCEP TRINPILELM CQLMNSEVSV PVPPNLWELA KNWSTLSRFS
LHCKEMEEDG TGLDPKMIAE VSIYEVNSRE DVLRVLRLIL RQDQEN
//
