ID A0A2K2D0D9_BRADI Unreviewed; 1727 AA.
AC A0A2K2D0D9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 08-NOV-2023, entry version 31.
DE RecName: Full=Guanine nucleotide exchange factor SPIKE 1 {ECO:0008006|Google:ProtNLM};
GN Name=100845304 {ECO:0000313|EnsemblPlants:PNT67744};
GN ORFNames=BRADI_3g31490v3 {ECO:0000313|EMBL:PNT67744.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:PNT67744.1};
RN [1] {ECO:0000313|EMBL:PNT67744.1, ECO:0000313|EnsemblPlants:PNT67744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:PNT67744.1,
RC ECO:0000313|EnsemblPlants:PNT67744};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:PNT67744.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:PNT67744.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:PNT67744}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:PNT67744};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CM000882; PNT67744.1; -; Genomic_DNA.
DR EnsemblPlants; PNT67744; PNT67744; BRADI_3g31490v3.
DR Gramene; PNT67744; PNT67744; BRADI_3g31490v3.
DR Proteomes; UP000008810; Chromosome 3.
DR ExpressionAtlas; A0A2K2D0D9; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810}.
FT DOMAIN 476..635
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1276..1725
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 308..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1727 AA; 195021 MW; 22A1F9A02E7814FA CRC64;
MSAADLVVAD ATAREWQRFK LIPRVSCAGN LDLDPLLNEN LEQWPHLNEL VQCYKADFVK
DDCKYGRYDS VAPPSFRSQI FEGPDTDIET ELQLCNARHS KPEETTEDDM PSTSGRQIYE
TEPCASSSNK PCSLSPLPAY EPAFDWNNER SLIFGQRVTE SLPATHISGL KITVKVLSLS
LEAGLVEPFG GTICLYNRDR REKLSEDFCF RILPTEMQDA HISLDRWSVF SLDAPSPSVC
LLIQLEKAAT EEGGVTPSVY SRKEPVHLTE KEKQKLQIWS RIIPYKEPFA WAMIPLFENN
HAGGVGDAVS PSSPLAPSIS GSSSQDSIVE PTSKLALEGK LNHYSSGSSV IVDISNLNKV
KESYIEDSLQ DPKRKVHKPV KGVLRLEVEK LHNDRNDTDT ISEGGSMNNE LHGAELNNGR
HHRNSFDGAH SYLNSSAVVQ KNARQNGQNS NAENGDNFQA FDFRMMTRSE PFSQLFHCLY
VYPLTVSLSR KRNLFVRVEL RKDDADIRKL PLEAIHPRDW STTLQKFVHT QISVGTRMSC
FHDEVKISLP ALLTPQHHLL FTFFHVDLQM KLEAPKPVIV GYAALPLSTH IQLLSDVSLP
ILRELVPHYL QESGKERMEY LEDGKAVFRL RLRLCSSLFP VNERIRDFFV EYDRHTLHTS
PPWGSELLEA INSLKNVEST ALLQFLHPIL NMLLRLIGDG GETLQVAAFR AMVNILTRVQ
QESSDGAERN RFLVNYVDFA FDDFGDRQTP VYPGLSTVWG SLARSKAKGY RVGPVYDDVL
AMAWFFLELI VKSMGLEQSH LFYHNLPQGE DVPPLQLKEG VFRCIMQLFD CLLTEVHERC
KKGLNLAKRL NSTLAFFCYD LLSIIEPRQV FELVSLYMDK FAGVCQSVLH DCKLTFLQII
CDHDLFVEMP GRDPSDRNYL SSVLIQEIFL TLDHDDLLQR AKAARILVVL ISKHEFDTRY
QKSEDRLYIA QLYFPLIGQI LDEMPVFYNL NAVEKREVLV LILQIIRNLD DTTLLKAWQQ
SIARTRLFFK LLEECITHFE HSRAGDSLLL GSSSRSPDAE RPVSPKYSDR LSPSVNAYLS
DASRHEIRLQ GTPENGYMWN RVIPQLSSPN QPYSLREALA QAQSSRIGST ARALRESLHP
VLRQKLNSFN YFKSTTRLRV MLTITLSELL SDVQVTQMKS DGSLEESGEA RRLRKSLEEM
ADVRSKDQLN ECGLPVNALE VSAEGSTDNR WSWVEVKHLS KCLVQALDAG LEHALLGSVT
TLDRCAAAEG FYKLALAYAP VPDLHIMWLL HLCDAHQEMQ SWAEAAQCAV AVAGVIMQAL
VGRNDAVWSR EHVASLCRIC PIVGTDVGAE VSAAEVEGYG ASKLTVDSAV KYLQLANKLF
AQAELYHFCA SIQELIIPVY KSRRAYGQLA KCHKSLTNIY ESILEQEASP IPFIDATYYR
VGFYGDRFGK LNKKEYVFRE PRDVRLGDIM EKLSHTYEAK MDGNQNLHII PDSRQVNADE
LQPGVCYLQI TAVDPVMEDE DLESRRERIF SLSTGTVRAR VFDRFLFDTP FTKNGKTQGG
LESQWKRRTV LQTEGSFPAL VNRLLVIKSE SLEFSPVENA IGMIETRTAA LRNELEEPRS
SEGDQLPRLQ SLQRILQGSV AVQVNSGVLS VCTAFLSGEP ATRLRSQELQ QLIAALLEFM
AVCKRAIRVH FRLIGEEDQE FHTQLVNGFQ SLTAELSHYI PAILSEL
//