ID A0A2K2DH69_BRADI Unreviewed; 692 AA.
AC A0A2K2DH69;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN Name=100845473 {ECO:0000313|EnsemblPlants:PNT73627};
GN ORFNames=BRADI_2g61370v3 {ECO:0000313|EMBL:PNT73627.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:PNT73627.1};
RN [1] {ECO:0000313|EMBL:PNT73627.1, ECO:0000313|EnsemblPlants:PNT73627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:PNT73627.1,
RC ECO:0000313|EnsemblPlants:PNT73627};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:PNT73627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:PNT73627.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:PNT73627}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:PNT73627};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CM000881; PNT73627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K2DH69; -.
DR EnsemblPlants; PNT73627; PNT73627; BRADI_2g61370v3.
DR Gramene; PNT73627; PNT73627; BRADI_2g61370v3.
DR Proteomes; UP000008810; Chromosome 2.
DR ExpressionAtlas; A0A2K2DH69; baseline and differential.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810}.
FT DOMAIN 225..333
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 327..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 77239 MW; 58C92187ED9A2EF4 CRC64;
MDVDDSAPRG GGEPPRIRRL EESVVNRIAA GEVIQRPSSA VKELVENSID AGASTVSVAV
KDGGLKLIQV SDDGHGIRFE DLPILCERHT TSKLSAYEDL QTIKSMGFRG EALASMTYVG
HVTVTTITEG QLHGYRVSYR DGVMENDPKP CAAVKGTQVM VENLFYNMAA RRKTLQNSND
DYPKIVDFIS RFAVHHINVN FSCRKHGANR ADVHSASTSS RLDAIRNVYG VSVVRDLMEI
EVSDENAVDG IFTMDGFISN ANYVAKKTTM ILFINDRLVD CTSLKRAIEF VYSAILPQAS
KPFIYMSINL PREHVDVNIH PTKKETVNSS ALAQANTQKE KGTDVSTATG AKSQKIPVSQ
MVRTDPLDPS GRLHTYWHGQ SSNLEKKSDL VSVRNVVRSR RNPKDAGDLS SRHELLTEID
SNLHPGLLDI VKNCTYVGVA DEVFALIQHN TRLYLVNVIN VSKELMYQQA LCRFGNFNAI
QLSEPAPLRE LLTMALKDDE SMRDENDKEK LEIAEVNTEI LKENAEMINE YFSIHIDQGG
NLTRLPVVLD QYTPDMDRLP EFILTLGNDV TWDVEKECFR TAAAAIGNFY ALHPPILPNP
SGNGIQLYKK NKDQMASGEH ADNDLTSTEE DDVDQELLAE AEATWAQREW TIQHVLFPSM
RLFLKPPKSM ATDGTFVQVA SLEKLYKIFE RC
//
