ID A0A2K2G048_9SPHN Unreviewed; 442 AA.
AC A0A2K2G048;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=A8V01_20170 {ECO:0000313|EMBL:PNU04425.1};
OS Novosphingobium guangzhouense.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1850347 {ECO:0000313|EMBL:PNU04425.1, ECO:0000313|Proteomes:UP000236327};
RN [1] {ECO:0000313|EMBL:PNU04425.1, ECO:0000313|Proteomes:UP000236327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA925 {ECO:0000313|EMBL:PNU04425.1,
RC ECO:0000313|Proteomes:UP000236327};
RA Sha S.;
RT "Complete genome sequence of Novosphingobium guangzhouense SA925(T).";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNU04425.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LYMM01000035; PNU04425.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K2G048; -.
DR OrthoDB; 3766879at2; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000236327; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000236327};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 30..126
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 140..430
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
FT REGION 171..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 47991 MW; E7A446AB9EB02EF6 CRC64;
MNWWTIDETH DPARKSWVEG AKGHRDFPVQ NLPFGVFSLA EGAPTRIGVA IADHVLDLGA
LATAGLVPAH LSDICRDATM ARLMGLSPQD RSALRRSLSD VLCDEARRSE ITPMLHPAQD
CMLHLPTRIG DYTDFYVGIH HANNIGRQFR PDNPLLPNYK HVPIGYHGRS SSIRPSGVPV
VRPTGQRKPP EADAPIFAPT ARLDYELEMG VWIGRGNDLG MPVPISDAAQ HIAGFCLLND
WSARDLQAWE YQPLGPFLAK NFHSTISPWV VTPEALAPFR MAQPLRPEGD PQPLPYLLDA
DDQAHGALGV MLQVHLTTQA MRDAGLEPHR LSHGPASNMY WTVNQMVAHH ASNGCNLTPG
DLLGTGTISA PDREGFGSLM EISQGGKMPL TLPTGETRSF LEDGDEISIT ATASAQGYVS
IGFGECRARI GQAIDKAISS AP
//
