ID   A0A2K2G5F3_9SPHN        Unreviewed;       691 AA.
AC   A0A2K2G5F3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:PNU06260.1};
GN   ORFNames=A8V01_12385 {ECO:0000313|EMBL:PNU06260.1};
OS   Novosphingobium guangzhouense.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=1850347 {ECO:0000313|EMBL:PNU06260.1, ECO:0000313|Proteomes:UP000236327};
RN   [1] {ECO:0000313|EMBL:PNU06260.1, ECO:0000313|Proteomes:UP000236327}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SA925 {ECO:0000313|EMBL:PNU06260.1,
RC   ECO:0000313|Proteomes:UP000236327};
RA   Sha S.;
RT   "Complete genome sequence of Novosphingobium guangzhouense SA925(T).";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNU06260.1}.
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DR   EMBL; LYMM01000003; PNU06260.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K2G5F3; -.
DR   Proteomes; UP000236327; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR017790; Penicillin-binding_protein_2.
DR   NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236327}.
FT   DOMAIN          63..234
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          268..587
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          630..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..647
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..691
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  75586 MW;  3F51A8CCDF4943F5 CRC64;
     MIRPPHVTTG TLRNSFDRRT IVVGAIQGGI GCLLASRMTY LSVFENEKYK LKAESNRVNL
     SLIPPRRGWI LDRHGQPLAS NRADFRVDVI PERMTDPDRT IAELGKLLSL SPIAMQDLQD
     KLDRSHGFAP VEVASRLDWE RFASVSVRLP DLPGVVTQRG YSRFYPTGPS VGHLIGYVGA
     ASAEEYEKDH DPVLLTPGYK LGKDALEKFY EKDLRGTPGA RRVEVTASGR IVRDLDTRED
     VPGKTVKLTI DAAIQDYAAR RIGPESAAVV VMDCQTGDIL AMASMPSFDP NSFSDGIGRL
     EWKMLSDDDH VPLRNKVLRG LYPPGSTVKP LVALSFLEAG LDPNESVYCG GGLRVGNRVF
     HCWQRRGHGQ VNMAKGIYQS CDVYFYHFAQ RIGMDPIAAM AKRLGLGQDF PLPVAGQSYG
     TVPSPAWKLK KYDKPWQTFD TVNATIGQGY FLVNPLQQAI QASRIASGRI IMPKLIHGHE
     HEPQASLGVP EEHLAYIRQA MSDVANGPGS APHSRLPFPD IKLAGKTGTA QVVGLNVGNG
     KGGLWKHRDH GHFICFAPAD NPRYACSVVV EHGGGSGAAY PIARDVLTYM FDKEKGMEAL
     TELEKKWGGT AKERLDARFR AYSAQYGVGA PKVSPEEERR KLQGAEQPDE PRQPINEAQS
     PAPEPADDTD RPAPPPSPAP TPTPTTGGTP Q
//