ID A0A2K2TNB8_9CLOT Unreviewed; 1657 AA.
AC A0A2K2TNB8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Type VII secretion protein EssC {ECO:0000313|EMBL:PNV59595.1};
GN Name=essC {ECO:0000313|EMBL:PNV59595.1};
GN ORFNames=C0033_12570 {ECO:0000313|EMBL:PNV61715.1}, C0033_22920
GN {ECO:0000313|EMBL:PNV59595.1};
OS Clostridium sp. chh4-2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=2067550 {ECO:0000313|EMBL:PNV59595.1, ECO:0000313|Proteomes:UP000236356};
RN [1] {ECO:0000313|Proteomes:UP000236356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=chh4-2 {ECO:0000313|Proteomes:UP000236356};
RA Huang C.-H.;
RT "Clostridium sp. nov. strain chh-4-2., isolated from the gut of a healthy
RT Taiwan adult.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNV59595.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Chh4-2 {ECO:0000313|EMBL:PNV59595.1};
RA Huang C.-H.;
RT "Clostridium sp. nov. strain chh4-2, isolated from the gut of a healthy
RT Taiwan adult.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNV59595.1}.
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DR EMBL; PKUU01000028; PNV59595.1; -; Genomic_DNA.
DR EMBL; PKUU01000010; PNV61715.1; -; Genomic_DNA.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000236356; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd00060; FHA; 1.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR023839; Firmicutes_EssC_C.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR NCBIfam; TIGR03928; T7_EssCb_Firm; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR PANTHER; PTHR22683:SF1; TYPE VII SECRETION SYSTEM PROTEIN ESSC; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50901; FTSK; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000236356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 263..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..167
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 699..893
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT DOMAIN 1137..1321
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 719..726
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT BINDING 1154..1161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1657 AA; 186988 MW; D13225632AC22FF7 CRC64;
MEKNMSIVLS VYSKSAFKEF VLPAINNDDT TIIVDKRLFR LHQDVVLKLE VIENRWMFAG
NRYSISRGTE PYGREPLRND DIFLVNTPYE EQLSITVSEQ ESSFCAYEKY LLKDGMAVTV
GNKPESMIRY QYQKLVSRDH AVLKMQGHVL RLEDTSRNGV FVNSVRVVGS AQLHFGDSVD
IFGLNMVCLG DILAVRPCKA LEINHELLKV WTMPVKEVSK PQGLIKREKE YFHRAPRNIE
KLEDEAVEIE APPSPQDMGE TPLAMVIGPA MTMAIPMLLG SGLAIYSSRM SGGNTSAFMY
TGLITAVSSA VIGAGWAIAN LRYTKDRKKK EELKRFERYS EYLIKCTDTI RGKYEKNTRI
LNEQYPSAAV CSGYDSTTMQ LWNRNSSHGD FLTERLGMGD IPFQVPITIP KEKFTLINDS
LADKPKFIQD NYSTLHDVPI CMDLLKEHLI GVIGGEHKKG AVDVVYNLVT QIAANNSYTD
VKLAFIYDKA QGIDADCWEF ARWLPHVWSE DKKTRYVAGT KSDASDVFYE LTKVFRFRSE
EQAGRNKETA PKPYYILVIA EPSFLEGEPA AKYIYGGAGN LGLSTILLAE KYEDLPNAVE
CIIQNDSSFA GFYNAASDYA KRTAVRFDEM NRNALEALAR RLSNIEVNEV EIGGEIPSSL
TFFDMYGISG LNELNVADRW RKNRTFENMR ALVGQKAGGA PCYLDVHEKY HGPHGLVAGT
TGSGKSETLQ TYMLSLAINF SPDDIGFFII DYKGGGMANL FAGLPHLIGQ ISNLSGNQVH
RAMVSIKSEN RRRQRIFNEY GVNNINLYTN LYKNKEAQIP IPHMFIIIDE FAELKREEPD
FMRELISVAQ VGRSLGVHLI LATQKPSGTV DDNIWSNSKF RLCLRVQDRQ DSMDMLHKPD
AAYLTQAGRC YLQVGNDELY ELFQSGWSGA SYDAELGNAK NVVAKMISET GKTGITGSHT
KMKRKEEVLE RWIIKLMGYA KEALEKTGRN MEKAVALIYQ MMERDHVDYA VNDYNTRRLM
DFTELYEDIC MEAEEDKKEQ AARIVAAAKR LGKKLPEQKE KTQLDAVVEY LKESAQRLGY
QNDIKLWLPV LPETMYLKQL PGYEEESFDG KRWPEQGHRW NLQVKIGLYD DPENQAQSPL
VVDFAEGGHH AVCGMVMSGK STFLQSLAFA LVSRYTPDYV NLYAIDFSSR MMSPFEGLAH
VGGIMYEGDM EKISKFFTMI SRILSERKLL FKGGNYSQYV QANGVTCPSI IVMIDSYANF
KEKTENQYED VLIQLAKEGS ANGIYLVLSA AGYSSSEIQS KIGDNIRTSI CLEMADKFQY
ADALKTMRVS VLPESNIKGR GLAVVDGSIL EFQTALSVEA EDDYKRMEAI KAVCERMNTC
WDGKRAKPVP EIPAKPVWSE FAALEDTVNA AADDRTLPIG YNMETAAVYG IDLSRIYCYL
ISGKARTGKT NLMKVMIRSA ALRGEKIWVI ESGAEELRQT AEEAGAEYLD SDQKVYHFFE
SIIPSFKARN QLKRQCVSEE LEEEAIYERM QEHEKYHIFI ADLKGFVNSI YNPQPGVASM
HGFVENITDK GVLHNVFFYA CFNQDDIRDV AGRKIYENFI RMKNGIHLGG KADEQRIFDF
NSLPFMERSK AMKAGSGMIP SEEGEKPCRV VIPLSRG
//
