ID A0A2K2TP89_9CLOT Unreviewed; 325 AA.
AC A0A2K2TP89;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN ORFNames=C0033_21835 {ECO:0000313|EMBL:PNV59921.1};
OS Clostridium sp. chh4-2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=2067550 {ECO:0000313|EMBL:PNV59921.1, ECO:0000313|Proteomes:UP000236356};
RN [1] {ECO:0000313|Proteomes:UP000236356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=chh4-2 {ECO:0000313|Proteomes:UP000236356};
RA Huang C.-H.;
RT "Clostridium sp. nov. strain chh-4-2., isolated from the gut of a healthy
RT Taiwan adult.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNV59921.1}.
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DR EMBL; PKUU01000025; PNV59921.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K2TP89; -.
DR OrthoDB; 9799422at2; -.
DR UniPathway; UPA00148; UER00236.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000236356; Unassembled WGS sequence.
DR GO; GO:0043752; F:adenosylcobinamide kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008820; F:cobinamide phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003203; CobU/CobP.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF02283; CobU; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000236356}.
SQ SEQUENCE 325 AA; 36359 MW; 01AF0114D6A46ED1 CRC64;
MLYLVTGPEK SGKSAKAEAL AVRLGEKRIY LATMVPFGEE GKKRVEHHRE LRKEKGFQTV
ECPVFIDRLD IPSDAVVVLE CIVNLTANFY FGTEETPAHP AEETIRLVCE KVNELKGKCQ
ELIVVTGQME YDQSYDKETR DYIETVHQVN RRLEQMADRL IGSEPQDYPR FPLFVDISKK
RVLVAGAGKI AARRAAVLAE FGAVVLVAAP DGCAQMEQLE QSGQVHWERR PVRETDLAGV
YLAVAATNRP DVNGRLAKLC RERGIMVSHA GDESQCSFYF PGIAREGELV AGVVADGKNH
SLAKQAAQSL RIWLKQFMAE RKDER
//