ID A0A2K2TZG5_9CLOT Unreviewed; 599 AA.
AC A0A2K2TZG5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=C0033_04950 {ECO:0000313|EMBL:PNV63451.1};
OS Clostridium sp. chh4-2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=2067550 {ECO:0000313|EMBL:PNV63451.1, ECO:0000313|Proteomes:UP000236356};
RN [1] {ECO:0000313|Proteomes:UP000236356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=chh4-2 {ECO:0000313|Proteomes:UP000236356};
RA Huang C.-H.;
RT "Clostridium sp. nov. strain chh-4-2., isolated from the gut of a healthy
RT Taiwan adult.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNV63451.1}.
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DR EMBL; PKUU01000003; PNV63451.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K2TZG5; -.
DR OrthoDB; 9809348at2; -.
DR Proteomes; UP000236356; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PNV63451.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000236356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 330..382
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 494..599
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 377..404
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 599 AA; 67275 MW; DB2D7B8FF35D8095 CRC64;
MAKFPLHAAS AAPKTFQRKL IFYNMLIIIC IACVVSFYNF TSYKNDVIKN ETNNSVNRIQ
TLSDRAALAY DEMVNILLNC AERKSLFLTT SLNYSQTGSN ERMALYAADV LRDFCAISGY
SEYIYKITLY NKDQLLIQAG SSAGSGDDLE NITSAPWFND YLTKTSSQYK LTLEESPFPL
GRYANPQIIP LVRPLQYNEH DDPKDAWVFL GISPKLFNSL LEILPEDRIL YITTGEGEVI
SSLNGGRLET RDLIGELTAS ESFSGVLRRK LSGQDCVITY QKQLVSGLLL MEIMPVEDMN
FDHTVIANTI VIIFFFCITI GLILSVLFSR QLGAPIKRLT GRLKQISHGD FSRDISIETD
DEIGMIGKQI NHMSGHISEL LDTRVQSEKE KKDLEIKMLQ AQINPHFLYN TLDSIKWIAT
IQKNSGIVQV VTALSSLLKN MAKGFNEKVT LRQELDFLNN YVTIEKIRYI ELFDVEIDVE
SESLYDAKII KLTLQPLVEN AIFSGIEPSG RSGLIKIHAY TKNGILYVSV TDNGIGISPE
NIEKLLTDTS RVTKSNMSGI GLPNVDRRLK LVYGEDFGVK IDSVLDEYTT ITVSLPLEV
//
