ID A0A2K3D7K1_CHLRE Unreviewed; 3879 AA.
AC A0A2K3D7K1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=CHLRE_11g467651v5 {ECO:0000313|EMBL:PNW76508.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW76508.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW76508.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
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DR EMBL; CM008972; PNW76508.1; -; Genomic_DNA.
DR EnsemblPlants; PNW76508; PNW76508; CHLRE_11g467651v5.
DR Gramene; PNW76508; PNW76508; CHLRE_11g467651v5.
DR InParanoid; A0A2K3D7K1; -.
DR OrthoDB; 318552at2759; -.
DR Proteomes; UP000006906; Chromosome 11.
DR ExpressionAtlas; A0A2K3D7K1; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 3.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43649:SF12; ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YCJN-RELATED; 1.
DR PANTHER; PTHR43649; ARABINOSE-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006906};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 548..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..650
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 317..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1670..1689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1958..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2077..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2209..2276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2446..2467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2660..2688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2714..2740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2804..2824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2859..2921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2952..3091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3155..3178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3359..3400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3819..3853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..977
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1960..1974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2661..2675
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2967..2991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3018..3042
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3879 AA; 381783 MW; DA70D37874AC3C3A CRC64;
MSALGTSVLL LNHTSYSWGG RYDPIAQVRT YASAAQAGVP LDVTVVDPAW WDARSGGQVE
GLRSTADIAG YAGWALVPSA LSGLRAEGRL QPLDGLVGAL RPLSAVWQDI PRVFRDAAAV
YDGQVLSLPY SAEVPLLYWR KDVFAQLGLG PPATWDEALR LAAVIDGTRI PCSGSPNETC
VQHGFCFGMP WGCFYDGLAL SAIWASMVAA YGTKGGLYFD PATMQPLFTG PAMREALRLY
RALEGLGPRP PQPCFRMEED YYLRHCSFGV SLTSLFKTFG FAYGGTLRGL MGVSLLPGSH
LVQDRATGKL EPCTPQLCPY ATPHEAAPPP PSSQPQPQAQ QEQQQQQEQG SETVLLVNRS
PYLGRGAFSF ALNRQAPPNA ALAALRAFTY SVTYQGGWPW ALDPTSRTSP VRTSHLSPAA
LPVWVAAGYH PDDTAAFLAV VAESLQHPNM ALGARQRGGT ELEAAVADAA VAAAYNGTAP
EELVQMLGQR YSSMLASQYG GDVAALRAAY WQDLGLRQDW PAPGGPAMQP GAGGSSSGSG
SSSLSPDAVA GIVVGCVLAA ALVATLAAAL LLRRRWRLVR SALQPVSAPG YSPDTSLCIT
DIQSSTQLWE ALDAGVMDAA LNLHNSVIRM LLPKHDGYEC HTEGDSFIVA FPCAASAVAF
ALEVQVSMMH QPWPEAVLQQ EPCAVVYHHA SPAPAATAPA FLPSGPMALA SPGPWPPAGG
GGGGGGGGAG PSAAASRAPS ALEAAPPYEH LYASLASSSI VAALQRSATA TTFAAAAAAA
VATTAPEGGD GAPTDWHSAV TSEAAAAALA AGSGSVRRPS PADFSSNVLR IQTPASAASG
ITQAALLQSN NSMPLGGLVH ALSAAASGSG TLFGGGWRRL SLMGGGGSAV GGIGGGPGSA
RRATSGNSRA TLLGGASSMG LGGGGGGGGG GGQGMAMGVG ALGLPTSSPG VSGAFPVSDL
PPLSDEGDDE EADVGEDVTD GGAAVGGSTH GGGGSGGRDD SESDSLPTLL ASPVLMPPSV
AAAVRAASIQ HHRISMGSGN FPSREISPDP GPGSGPGGVQ GPPLSPAGAA VVLPHHAGLR
SSRLSFLRRL QGKPHPSHVS PSPSAAVGTV TGAGTGGPDT HLGALPPSSS QFWTPAQLPS
ALLGRASSGE APADSGASVS ANLRALQVLI KRQTGTAPPT LLPIRSGRST GLNTTELGGG
AAAALAAGEG EHALLPRRGG QTSGSGTPMA TPAELRQFSS RYSLNYPRQD SGTAPAGHVE
GRWSGRQQPR GLLGVAQARA ASGSAADLTG GSAGSGGGGR AGRGGSQLPE SNTAARQSSL
APAPPSAAAT SSAVVAVSAS PPPSEPQPVG MPAYRKSNPD LTTGERDYAV QSHGSHRSTF
NSERLARLTG SRPALAATNL GDGGAAGGGP DARPLPPRPP RLSLTVAAHA GGGSTGSFRV
AGTGRGTAAS TPIGLVDPVR GSRLGLYDGG GASDTSASVV PSSPSPHGPS GAAAAPVSAA
AERRGVQLSP LRASSVMGPL GGRSGGSYPY ATAYPSTPAV AEPVPAAAAV AVIHGADSLG
RGNAAAAAAA RPHSPRVHGG AARKAFDRRS CSDSGVEHSR PLRKVDEEED GGSDAPVFAR
GSAVPVRLSL SGWDTSVDAE SPAAAPSAAA ADAHGLGLAF GSEPLPQPAA AATQAAAADA
HTPPASSSGS ATLALAAASG DKMVSIFDRW HTKWGLAEPQ EDAHRPLQDV GRAEGSAGAK
AAAGLSANTD AAAAALEKQG PPAPPSLTVV SATQALLPRK QGSAAVQAAG RCSGGHAESS
IGAGSGAGAG TGSGAGAGTG SGTVVTDACG TDVAANAATA AASDGGGSGG GGGGSATAIR
PLGSGACWPG GTGVEGVSGG VADRQLSTTS LTEGLASRTA SAAMLFTSAS LHNHLSPLGR
TSTRASGVAA PAGTGLAVAG SGSSRTATAS GGVVGMTAGA SRSPANSVTA QGRSGAPAMP
TAPSLLGRFS RGGGSGGSGG MPPPSGPWSF ANAVTIAAAA AAAANAQGAA AAALARASVS
GCVTATPPES GIANSLPASA ATEHMTGVGE VGGATSAVQA EPQSSGLGRG SGARAPSGAG
AGAASLHSAT PPAPGLTPQP AAATATASSM VVKMASGGGS SPAALGPFAG DASASGRRFA
AITSWLTTAF GGPGAGGGVA SGFTQPPPSL ASTGPLGKGD ASCMSVAAPA PPPPTPTGRA
AALQSTTARS GAMYRGARSR PSLHLSLRQR APAALESDTS GDNGAGGGGG GGRDHHGHAA
GYHGGAGGGS MHLCFRGFRV RVGICSGLVP GRDVVYVKDH GRRTAYSGAC MQATKLISDA
ALGGMVLLSA STAERLLPLP RKDIQGLIMW HKGRYVLGER GASHDAVGAA AAAASHLLHA
PCAPDGPVAE SIDVAAAADA AGLSTTAAAS LATLALANDH GRGIQGASRD GSGALGPAVR
SSGGTGTGAS GRLTAAMAAL ALASPSAATN TRPAQPHAHL HSHVHLQTSR WCGGGLARGS
PEAQDLYQAM VLPLAARQLL LERQPLRTHG PGPLLPGLLA APVGGVTLAL VQVVGLPTLM
AWDADVATAA LARLTAAALQ LLAAAGGYPA AAEGGELLAA FRSAPAAISW MVALEEHLRT
AVDWPPELLT HELGDELVVA LPAAPPPPPT AQHQHQPPQR APRQSGVGLA AAATAAAGSV
SSTIRRALQQ SLSAVNRSGS TGGGANGLSG EEGAPYRPRL SRAGGEALGI TATASASGQA
YGLAGGSPLL PPWLLMASRS AAGGSSFASS AGANAAAAAA SGGAATRSSG DENEPGGGAD
TSSRSLRRLF SASGGAAGSL SQRFMGRART SVHRVQALSP LARDPISSGG GASAACTAEG
DGGGGSGGGA SLSAGPLPAR PARVLGHPPR SYELESAGEG GQPEAVADAA AVLGAESLLA
AAAAVAASPV DRRVHHHHHH HHYHYQEQQQ QQQPGLQVSL SSPQLPRHRT TSPHPQAPPP
LLVEGDEEQS AALAEPRTCL LPPPPAPLPP PAAPPPPFAP SAAPADALAH MDERPPPRPP
QLQLRPQLRT SDAAEAVAAK ADTPPQRSTP RAVAAATMAF FRHGRTDGGA VGGSAGNSRG
GSARSLVAGG GGSGARRSFA GVVAEYAGAV AKAPSRASMP SRPQGLFRTE PGGGGGGGRC
MDEAVDEDEE LDEVGAAYGD AFGYGGGDVG SRAGGGAGGG YDEDGIFSLV AGGAQQTAGG
DGSRATTGGI TMNLRLANMG GGGGGNERRS IGGIAFGGGF ANGGEGMGLG GGFGGAVGGG
GGGAGGGLDS PSHSGSLFTL GSVLRRRSTS MRLPSMRAFG FGGAAGGGGG GGVVSSGSNI
VGGGERHSGG GDRDRPHDLY GAGAAASPRY HGQPQHGGSR RRTADVAMLP AGAFVSRTSN
AGHQQLLRAQ MLQYAAATGR NSDEAAALVP RNLASPGAMR AQGGASTASP FATGFAAAAV
AAAAAPAVPL VLVSDHGAEG ADAAGAGAVS GGGGGGVGYA PRAAEESNFY MPTTTTTQQP
QEQQVQQEHP AFTFDGMPRA APAIAGGPAA AAGGTRSAAA PLPWSPSPHP AALPASAAAA
AIAVWPSDGA PPHLPNTPPP PYAAAHRSLP LPLLQQQHAA VYQQPHHTSA LPAVPLPQPP
HAHAEHAPPM QQRCVLRGLR IRCAADEGMF VQDGSISAAR LYRSQHGGKT YGRLTKLCRT
ALMGQVLCTR AVAKRVHRAA VAGDATAAAL QLTPLPPGGG KRTVAAAAAV VGAGDDADAL
AAAAAAVTWG GGGTATATAV NAGGAEHGAP AAVAAAAAVG HSHGNSLRQQ EEDGSGLHHE
GGPSRSGMAG RSIDLVGGIP KADVWVCSWA PHTQRAHEA
//
