ID A0A2K3DA82_CHLRE Unreviewed; 5102 AA.
AC A0A2K3DA82;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Fibrocystin-L {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHLRE_10g436800v5 {ECO:0000313|EMBL:PNW77443.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW77443.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW77443.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906}, and CC-503 cw92 mt+
RC {ECO:0000313|EMBL:PNW77443.1};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2] {ECO:0000313|EMBL:PNW77443.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CC-503 cw92 mt+ {ECO:0000313|EMBL:PNW77443.1};
RG Chlamydomonas Annotation Team;
RG JGI Annotation Team;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Grigoriev I.V., Rokhsar D.S.;
RT "WGS assembly of Chlamydomonas reinhardtii.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM008971; PNW77443.1; -; Genomic_DNA.
DR EMBL; CM008971; PNW77444.1; -; Genomic_DNA.
DR STRING; 3055.A0A2K3DA82; -.
DR PaxDb; 3055-EDP05658; -.
DR EnsemblPlants; PNW77443; PNW77443; CHLRE_10g436800v5.
DR EnsemblPlants; PNW77444; PNW77444; CHLRE_10g436800v5.
DR Gramene; PNW77443; PNW77443; CHLRE_10g436800v5.
DR Gramene; PNW77444; PNW77444; CHLRE_10g436800v5.
DR OrthoDB; 316276at2759; -.
DR Proteomes; UP000006906; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 5.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00710; PbH1; 6.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000006906};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..5102
FT /note="Fibrocystin-L"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014294269"
FT DOMAIN 1588..1750
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2372..2496
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 3244..3374
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT REGION 4200..4246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4292..4396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4432..5102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4228..4246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4292..4391
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4440..4454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4467..5102
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5102 AA; 533064 MW; 5431F2AFDE11DF97 CRC64;
MKGSAWPLSG AALGLSLCVA LLLAAGASAQ LYITDVDPTS GSLGGGTRMV IQGSGFSEDR
YTGSNVVFIG TYPCTVINHL TSDSVITCLT SPAPLEGKYD ITVVVDGLDS VTYSTPYSYD
MDYTPTLNFV FPSAGPPGVN PFVYGTPTWG INNECSSNAD TGYMYSSTPA CVESVLAGDY
SATLPSGADG YTYLGYLSYY TSLYRINFTM PLDNTGMGLE GLGTAGNMNL TISFGGNAYG
SQPYVARSAY RTGLSDNLPY MYQQYAEVAS VSPQTGSRAG GTVLTITGRG FPTLTPDSTE
TVTVTAAGAP CRVLSSNFTT VLCETGPASV LVPGYRAPVP AGGLKGLYPA MRGIEYELYN
ASINANCSPY TEGGDALNRL WRFNNTIKLS DCNNSYSRIL TGAWEAPPED TQLELSTYNT
KAFFIAPRDG NYTFHVSCDD QCRLNGTYQL ANGTVVTGVP LAYMPQWSSF NEWFKYDEQM
SDPILLKAGQ AVLLEATGAN NRGPGGIQVG ATVPSTVARY NSLPEIQTIN VNGAALNRMV
EIKYMWGGGF KHVYNITVTA PTVALLVNSE VGVRVNITNS TNAAKRWDPR FMLDDKASDI
ARSFAYYLGI SGDSVGVSMS IVGSTMRLQV GISAPVFAST NFNFSIGFFM VAQPPFPPSP
PPPALGCAYF NPRSLREMEA DALAADGSSW LDRRSLIPNI TSWTVTIAAS APVAAVTPGG
QWRLISGGSE RVLDWNADAA TVNAAFAALA GTGVDIASSY SKVEGAYLTN VWTVVYPIWI
LNNVPAVTVA NASGVPAGAR VVMTVRNGTT ALGGSFRVAF GSYCESVVIN LTDSADDVQV
KLSTLPGVKA PLSVVKTGAS YGGSIKWRVT FDPQGNPGNM PQLRVIDAKN VTGTDVRVFV
EETLQGSTRQ FFAPIPTEMT ALASTVPVDL AVRVNNIPSA CASPRGAAGC TFTYSAALTP
SITAVSPAAY IFPSTAGFTT LTMNISGAGF NSSIAGNAVS LDDDTQCAVT FASAGLITCQ
LPNTGAGGAR LVRVRVAGKG FAGSANTAVV TVSVRVLAVT GVSPAVVSAT AGATVLNVTG
RGFDDVVCDR NRVSVGAAAC GVLTCAYDQL QVLCATPVVA GAAPASPTPV PVGVRVFNAA
GALLDFSDNT TTTLADAAGP SIAVITPLSM GSSGGVIQLA TTGLAAPFAN GTDIGPFPLV
WLVSGNVAAV NTSSATAMAA LASALDNEDL RYPCANATYD NSTGLITCTV PYVPSGTYSV
ALEPAPYNGG LNVTTWLLSR QAIVFTMTIA GVAPQAGSVG GGVVLVINGT GFAPGDRMRE
NAVFVTVPVS TTFLNGIVPC DVINASTTEI RCRTRAHIAA DADATDPFAL NVQPRATTAN
SVVVVACGQS FNSSATVDAL RFYCWAQPTS ARAVCTGTVG ACTFAYTWAE TPSLTSVATP
NMDGVVFPGD NITVNGIQLA DVVQLDLRSP NGTTSGSCAG ADLTRGATAV SCNIPAGTPA
GVYQVVLLTS REGRSVDPRK VGRIVVTARV VAVAGSVGSL GGGGSLTVSL AGAIFNTSFP
DRNTITVDTL SCNITSFNAT SANCTLPPII GSVKAEFWNL PAESWSVDVK NYTKPDFVTY
YQSISNVWWS TPAYAMWPSG LSPDLDTILP DYFGGRFTFY MRVNRTARYS FVFNSIDDVA
RLYVDDVYIG YHGEQPLRVN LTAGRPYKFE VMYYENLGGT SISMVWDAGD GGAIDRALPW
GTVSPQPPAA PIDVTVTING VPAVSACPAQ DLNLTMPGTS PSPIPGEPAV LSLPNNTCAY
VFTGYRTPTI LAASGLPAVL PGVVSFTGNF LTTAVADFSI TVSGQNCTGI VVRAAGAGFP
TGSSIVSCTL PSLPGRVSKP ILVSVAGRGV ARAGRDLDAS ALWPSFPLAI TSIVPDYTSH
FGGFDIYING FGFVPLTGPM ANMGRQMRVV LGGGTNPGNL TTVPMPIVSA STTQIRIKFP
RILPAPGYIA DFNIWKSITV VLVDQNTDSS NWQSQWEAIQ FDRTSTPVFN ATTQAVVPAV
TSLGAVNATT VNLSYSIYYG WSIAVNATPI GNFSRMSVSL TPTPTALPAA LNYTGVFPVC
VNATVTNSSW VRPVYRESLS CTLPAGTPAN VYTAWICQPG GTLGTGCSPA PGTVTVPLVL
TGISPRKGSY AGGMSVFIQG RGFVSNPALI QVFFGDVPCN VTAANNLGVT CLLGSALPAI
PTGSNPIALM PSKPLLAGLR ISPADGAPLV NYTSANVTFT FDPVQTPVVI SVSMTRGSTE
GGTQLEYGLI NMAGVFAQNV TVLLGDNITC TNLTLTPGYL SSGDLGAVVR CLTPKPPTRQ
IGPKPVRIMI TGRGMAACSA TYEYVDLWSR RTTWGGGAPP VEGSLVSIPP GINVMLDVSP
PLLGALVVEG RLTFDESLTD EIELRANYII VRNGGVLSVG TEDVPYGGKK AKITLVARPH
EILELPLYGG KALAVRDGLV VFHGQHKTPT FTRLTQTADV NSTVLNLAGV VNWVAGDEIA
VASSSFFTDE SETAIIVSVE VDDYYNVSTI RIDRKLNFTH LGVVEEIAGG AAGASIDMRA
EVAVLTRNVV FQGDEDSERY MFGAQIMVNT PSTRPRANIR FEQAEFRQTG QAFRLGRYSI
HFHMHGDLAY QSWVKGCAIH HTYNRAVTIH GSHRVILRDN VAYQCMGHTF FLEDGIETGN
IIEGNLGFST KASPALLNTD TTPATFWITN PNNTYRNNVA AGSDAYGYWV RLLDHPEGPS
YTTSVCPKFT PLGRFENNVA HSNMFYGLRV HPEYYPKKEP CADNKFQQVP AVFNGLTTYK
NGVKGAIATQ VGLVVFSNIT AADNGAGPKM HIVNGKDNGA GIEFSWIVDD RNRANVPLDL
MAGLRDSIIV SRTVGGFVGT AGQWPARDRK ITGIITQSPP LGDPKHSALL SITNVTFVDY
TGGQFFALEG CGKCKTFQGG ATSFMKQLRF VQSNAGSYPA LSSWSYGHQA VYLDTDGSLI
NSQNLPPELM SALPWSLATP GGTWHSAVES ELFDPAECVY VRGKGTSNDG AICSPDLVFR
RIMLNEHLPT SIEFRDLRVT SLATNRTSLV HFTKYNEKGY QFTAATHRDY WLQWESPFRV
DPTTARFHKM DLMNDTDGWI HMSFKFLARN DRVEVNGAVT AGAYPGPPPE GAPHGSSYYS
KLLQPNSWWW GNFTYNDTKF TMYMAGDQDD ILRVTPQACP VTGCTFDFNV TADLRGTLFW
SDDNTWLNRA GGKPKAGENV TVPFGWNLIL DEDTPPLADV VVLGNLTFET ASRNVLTANN
IFVAAGGRLS AGAPGTPLPP AARATIRLSG YRGDASRAMA SDLVFGSKFI SVFRGGTLDL
HGSSVGSRWT RLGATAAAGS NYLVLDPPQP GWAVGSSILV TSSSYNVWQA EERTITAVQN
NGGTIFLDSP LVHPHYAFTA SFSGAPTVVD MRAEVALLSS NVVLESLEGT GVEAAVGGER
YGCRVIVNGA STARISNTAL RYCGQAGLDR ATILFDRLTA LQGGAPNPSF VADSVLYKSQ
EAAVFVDGDN FTSPITLSGN VIFGSYDKDT VEVMTSGNLI RGNLALGLVK IMDGVSGFDT
RLPAVFNFHS ARNNVTGNVV AGSERLGYRL AGPPCSAVNT TSLGVGTPYV FLNNSAHSTL
VGMVLEASNE SLAEGCTALA NFTSYMAWDF DLLTLKGIET HVLLRRINSL NPKHAGVLVL
KVGEMTQKAE VEMFDSIIAG RTHPEVCALC EQQGQPGCHP KLSVQSYNSW NPFTPSVGLV
SATFATEFTP GPEQKPWDGL KGYQTIHGIM RVYGTTFANW AGASACPGSA QGAYALANHP
KAPDAFHPHY LYRSNVVNVR STTTESGLFL FTGPNPDWRN EADCGFQTYT QPDGSILELN
CAGPKHAHFR DLDGTLLSGL TGAGWNATAG DTAVGYFGSP RSFPYDQGTP VIPGPCTFLP
AIDGYACAAN SSAYALPNAD MKPVVPAAAG GIGGNQQLFV LESRDADTED RNFGPVFFNV
SGSIDMTVVA MDQGWCFAYT CQKRLSTFWT YLPIGHVVGI NFTGTPATVF RTWLPYAAPE
EEIVVEIYYM MIPNRRFVWL PESGRVPASN FKPRPYDGAT AHGDYYWDQN TTTLTVKITG
GRTLEVRGEN AVVVGWGLAL SINQFYDTQE LFLTNLANFL GIPRSRIYVA KIVPGSSRRR
AALEGGSGGS SGSQVDIMIY DDPATSNNDP LPEPQIDTSG NVDSESAAPL LGASQSEREA
ARAEVLGQLS PPPMPPPMPV LLNMVVFDPP APPSPPSPPL PPSPAPSPPP SPAPPSPAPP
SPPSPAPPSP TPPGPPSPRL PSPAPPPSPG IAVSPPVPPS PAPPRPSPPV PPPSPAPPSP
PQPPAPPSPN PSGVSFTAAL SNLKALIVDT NTASAVLGVT VAEVADVQVL AGVSSSDGGS
GGADGGSGTN DDFNNGAGDL LKALGRAPPS PAPPSPDPPS PPPLPPPSPP TPPSPRPPSP
RPPSPRPPSP VPPSPVPPSP APPSPRPPLP SPPAPRPPRP LPPSPRPPRP PSPPSPSPPS
PRPPAPPSPS PPSPRPPSPA PPSPAPPSPV PPSPAPPSPA PPGPLPPSPR PPAPPSPSPP
SPRPPSPNPP SPRPPAPPSP PPKPPVPPSP PPKPPVPPSP PPAPPMPPRP PSPSPPSPRP
PSPPPRPPSP TPPSPKPPGP SPPPAPPSPS PPSPAPPSPP SPAPPVPPSP VPPSPSPPSP
APPSPSPPSP LPPVPPSPLP PRPPSPTPPS PKPPRPPSPP PAPPVPPSPP PSPPVPPGPP
PKPPSPPRPP SPSPPSPRPP SPPPRPPSPT PPSPKPPGPS PPPAPPGPPT PPSPPPTPPS
PEPPSPAPPS PPAPPSPQPP SPQPPSPAPS PLPPSPSPPS PRPPVPPSPS PPSPRPPSPA
PSPRPPSPSP PSPRPPSPAP SPVPPSPAPP SPRPPVPPSP SPPSPRPPSP APSPRPPSPS
PPSPRPPSPA PSPVPPSPAP PSPRPPSPAP SPVPPSPAPP SPRPPVPPSP SPPSPRPPSP
APSPVPPSPA PPSPRPPSPA PSPRPPSPSP PSPRPPLPPS PQPPSRSPPT PPPWPKPPSP
AP
//
